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Search results 201 to 290 out of 290 for Nbn

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Type Details Score
Publication
27320916 | J:238371
First Author: Rocha PP
Year: 2016
Journal: Cell Rep
Title: A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.
Volume: 16
Issue: 1
Pages: 48-55
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Publication
18614044 | J:138550
First Author: Stracker TH
Year: 2008
Journal: Mol Cell
Title: Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
Volume: 31
Issue: 1
Pages: 21-32
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Publication
33586242 | J:306148
First Author: Chen Y
Year: 2021
Journal: Cell Prolif
Title: Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis.
Volume: 54
Issue: 3
Pages: e12972
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Publication
33524014 | J:305161
First Author: Dar AA
Year: 2021
Journal: PLoS Biol
Title: The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Volume: 19
Issue: 2
Pages: e3001041
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Publication
16400328 | J:106450
First Author: Ramiro AR
Year: 2006
Journal: Nature
Title: Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Volume: 440
Issue: 7080
Pages: 105-9
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Publication
11161784 | J:66992
First Author: Douglas KR
Year: 2000
Journal: Genomics
Title: Partial transcriptome of the developing pituitary gland.
Volume: 70
Issue: 3
Pages: 335-46
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Publication
22369660 | J:320080
First Author: Wang B
Year: 2012
Journal: Cell Biosci
Title: BRCA1 tumor suppressor network: focusing on its tail.
Volume: 2
Issue: 1
Pages: 6
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Publication
24793032 | J:212924
First Author: Katyal S
Year: 2014
Journal: Nat Neurosci
Title: Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
Volume: 17
Issue: 6
Pages: 813-21
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Publication
22522401 | J:191367
First Author: Lee Y
Year: 2012
Journal: Nat Neurosci
Title: Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.
Volume: 15
Issue: 6
Pages: 819-26
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Publication
22266795 | J:181920
First Author: Lee Y
Year: 2012
Journal: EMBO J
Title: ATR maintains select progenitors during nervous system development.
Volume: 31
Issue: 5
Pages: 1177-89
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Publication
11555636 | J:71817
First Author: Sutherland HG
Year: 2001
Journal: Hum Mol Genet
Title: Large-scale identification of mammalian proteins localized to nuclear sub-compartments.
Volume: 10
Issue: 18
Pages: 1995-2011
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Publication
22212482 | J:316150
First Author: Li R
Year: 2012
Journal: Cell Res
Title: A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons.
Volume: 22
Issue: 5
Pages: 859-72
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Nbn<tm1Xu> | MGI:2182645
Name: nibrin; targeted mutation 1, Yang Xu
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nbn<tm1Zqw> | MGI:2682000
Name: nibrin; targeted mutation 1, Zhao-Qi Wang
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nbn<tm1.1Md> | MGI:3505757
Name: nibrin; targeted mutation 1.1, Martin Digweed
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Nbn<tm1Jpt> | MGI:2183796
Name: nibrin; targeted mutation 1, John H J Petrini
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Nbn/Nbn
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn<+>
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn Tg(Mx1-cre)1Cgn/?
Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn
Background: involves: 129/Sv * 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn Tg(CD19-cre/ERT2)1Cgn/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:7400 | Nijmegen breakage syndrome
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Protein Domain
IPR016592 | Nibrin_met
Type: Family
Description: Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and Nbs1, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis [, , , , , ]. Mutations in the NBN gene coding for nibrin cause the Nijmegen Breakage Syndrome (NBS), a rare autosomal recessive disorder characterised by genomic instability and increased risk of haematopoietic malignancies [, ].
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Publication
22373003 | -
 
First Author: Chrzanowska KH
Year: 2012
Journal: Orphanet J Rare Dis
Title: Nijmegen breakage syndrome (NBS).
Volume: 7
Pages: 13
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Publication
25119968 | -
First Author: Alster O
Year: 2014
Journal: PLoS One
Title: The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.
Volume: 9
Issue: 8
Pages: e104964
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Publication
12422221 | -
First Author: Tauchi H
Year: 2002
Journal: Nature
Title: Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells.
Volume: 420
Issue: 6911
Pages: 93-8
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Publication
10888888 | -
First Author: Zhu XD
Year: 2000
Journal: Nat Genet
Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
Volume: 25
Issue: 3
Pages: 347-52
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Publication
19759395 | -
First Author: Yuan J
Year: 2009
Journal: J Biol Chem
Title: N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.
Volume: 284
Issue: 46
Pages: 31746-52
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Publication
11448772 | -
First Author: Ranganathan V
Year: 2001
Journal: Curr Biol
Title: Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit.
Volume: 11
Issue: 12
Pages: 962-6
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Publication
9590181 | -
First Author: Carney JP
Year: 1998
Journal: Cell
Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Volume: 93
Issue: 3
Pages: 477-86
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Publication
15296753 | -
First Author: Ciapponi L
Year: 2004
Journal: Curr Biol
Title: The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.
Volume: 14
Issue: 15
Pages: 1360-6
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Publication
15135728 | -
First Author: Gorski MM
Year: 2004
Journal: DNA Repair (Amst)
Title: Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae.
Volume: 3
Issue: 6
Pages: 603-15
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Publication
9705271 | -
First Author: Trujillo KM
Year: 1998
Journal: J Biol Chem
Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Volume: 273
Issue: 34
Pages: 21447-50
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Publication
11454871 | -
First Author: Trujillo KM
Year: 2001
Journal: J Biol Chem
Title: DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.
Volume: 276
Issue: 38
Pages: 35458-64
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Publication
17698079 | -
First Author: Ghosal G
Year: 2007
Journal: J Mol Biol
Title: The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity.
Volume: 372
Issue: 4
Pages: 864-82
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Publication
19409520 | -
First Author: Waltes R
Year: 2009
Journal: Am J Hum Genet
Title: Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Volume: 84
Issue: 5
Pages: 605-16
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Publication
24168161 | -
First Author: Berardinelli F
Year: 2014
Journal: Int J Radiat Biol
Title: Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells.
Volume: 90
Issue: 1
Pages: 45-52
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Publication
23671188 | -
First Author: Yin Y
Year: 2013
Journal: Mol Cell Biol
Title: Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.
Volume: 33
Issue: 14
Pages: 2732-47
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Publication
21734400 | -
First Author: Murk W
Year: 2011
Journal: Hum Hered
Title: Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma.
Volume: 71
Issue: 2
Pages: 97-105
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Publication
15964794 | -
First Author: You Z
Year: 2005
Journal: Mol Cell Biol
Title: ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.
Volume: 25
Issue: 13
Pages: 5363-79
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Publication
17672843 | -
First Author: Waterworth WM
Year: 2007
Journal: Plant J
Title: NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants.
Volume: 52
Issue: 1
Pages: 41-52
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Publication
12944481 | -
First Author: Ueno M
Year: 2003
Journal: Mol Cell Biol
Title: Molecular characterization of the Schizosaccharomyces pombe nbs1+ gene involved in DNA repair and telomere maintenance.
Volume: 23
Issue: 18
Pages: 6553-63
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Publication
12944482 | -
First Author: Chahwan C
Year: 2003
Journal: Mol Cell Biol
Title: The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.
Volume: 23
Issue: 18
Pages: 6564-73
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Protein Domain
IPR040227 | Nibrin-rel
Type: Family
Description: Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and Nbs1, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis [, , , , , ]. Mutations in the NBN gene coding for nibrin cause the Nijmegen Breakage Syndrome (NBS), a rare autosomal recessive disorder characterised by genomic instability and increased risk of haematopoietic malignancies [, ]. NBS1 homologues from plants are also involved in DNA repair and recombination []. In S. pombe, Nbs1 is required for DNA damage repair and S-phase DNA damage checkpoint [, ].
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Protein Domain
IPR004584 | Rad50_eukaryotes
Type: Family
Description: RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [, , ]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [, ]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the MRE11 active site [, , ]. This entry represents the eukaryotic Rad50 that is distantly related to the SbcC family of bacterial proteins.In Saccharomyces cerevisiae, Rad50 forms the MRX complex with Mre11 and Xrs2. In humans, RAD50 forms the MRN complex with MRE11 and NBN (also known as NBS1). Mutations in the RAD50 gene cause the Nijmegen breakage syndrome-like disorder (NBSLD) []. The genetic variations in the RAD50 gene have been linked to susceptibility to asthma [].
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Protein Domain
IPR013908 | Nibrin_C
Type: Domain
Description: This is the C-terminal region of Nibrin (also known as DNA damage repair protein Nbs1) that has been identified to be necessary for the binding of Mre11 and Tel1 []. Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and Nbs1, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis [, , , , , ]. Mutations in the NBN gene coding for nibrin cause the Nijmegen Breakage Syndrome (NBS), a rare autosomal recessive disorder characterised by genomic instability and increased risk of haematopoietic malignancies [, ].
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Publication
22396666 | J:183396
First Author: Krenzlin H
Year: 2012
Journal: PLoS Genet
Title: DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.
Volume: 8
Issue: 3
Pages: e1002557
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Protein
Q9R207
Organism: Mus musculus/domesticus
Length: 751  
Fragment?: false
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Protein
Q3V0R5
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3UNL2
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
E9PUJ2
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
A2AMG5
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: true
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Protein
P70388
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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Protein
A8Y5I3
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: true
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Protein
Q5SV02
Organism: Mus musculus/domesticus
Length: 1312  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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