|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 404 for Hdac4

0.039s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Chen C
Year: 2016
Journal: Biochim Biophys Acta
Title: Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation.
Volume: 1863
Issue: 7 Pt A
Pages: 1633-42
HT Experiment
Series Id: GSE49383
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Worton LE
Year: 2018
Journal: PLoS One
Title: Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression.
Volume: 13
Issue: 11
Pages: e0207354
Publication  
First Author: Guo X
Year: 2015
Journal: Nat Commun
Title: A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa.
Volume: 6
Pages: 8005
Publication
First Author: Seo HW
Year: 2009
Journal: FEBS Lett
Title: Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.
Volume: 583
Issue: 1
Pages: 55-60
Publication  
First Author: Nishimori S
Year: 2021
Journal: Bone
Title: PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.
Volume: 142
Pages: 115709
Publication
First Author: Federspiel JD
Year: 2019
Journal: Mol Cell Proteomics
Title: Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Volume: 18
Issue: 8 suppl 1
Pages: S92-S113
Publication
First Author: Fang M
Year: 2016
Journal: Biochim Biophys Acta
Title: HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells.
Volume: 1859
Issue: 2
Pages: 294-305
UniProt Feature
Begin: 389
Description: In HD; disrupts sequence-specific DNA-binding; no effect on homodimerization or interaction with HDAC4 and HDAC5.
Type: sequence variant
End: 389
Publication
First Author: Yang Z
Year: 2017
Journal: Am J Pathol
Title: Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases.
Volume: 187
Issue: 4
Pages: 781-797
Interaction Experiment
Description: Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
Interaction Experiment
Description: Hdac4 Interactions in Huntingtons Disease Viewed Through the Prism of Multiomics.
Publication  
First Author: Fitzsimons HL
Year: 2015
Journal: Neurobiol Learn Mem
Title: The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?
Volume: 123
Pages: 149-58
Allele
Name: histone deacetylase 4; targeted mutation 1, Eric N Olson
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
Publication
First Author: Kirsh O
Year: 2002
Journal: EMBO J
Title: The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
Volume: 21
Issue: 11
Pages: 2682-91
Strain
Attribute String: congenic
Genotype
Symbol: Hdac4/Hdac4
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Hdac4/Hdac4
Background: B6.129S(Cg)-Hdac4
Zygosity: hm
Has Mutant Allele: true
HT Experiment
Series Id: GSE38219
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
HT Experiment
Series Id: GSE38218
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: transgene insertion 1, Eric N Olson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Hdac4/Hdac4 Tg(Myog-cre)1Eno/?
Background: involves: 129S/SvEv
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Col2a1-Hdac4)1Eno/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Hdac4/Hdac4 Scn10a/Scn10a<+>
Background: B6.129(Cg)-Hdac4 Scn10a
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Hdac4/Hdac4 Hdac5/Hdac5 Tg(Myog-cre)1Eno/?
Background: involves: 129 * 129S/SvEv * 129S2/SvPas
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Wang Z
Year: 2014
Journal: Epigenomics
Title: HDAC4: mechanism of regulation and biological functions.
Volume: 6
Issue: 1
Pages: 139-50
Publication
First Author: Kassis H
Year: 2015
Journal: Stroke
Title: Stroke Induces Nuclear Shuttling of Histone Deacetylase 4.
Volume: 46
Issue: 7
Pages: 1909-15
Publication
First Author: Parra M
Year: 2015
Journal: FEBS J
Title: Class IIa HDACs - new insights into their functions in physiology and pathology.
Volume: 282
Issue: 9
Pages: 1736-44
Publication  
First Author: Glozak MA
Year: 2005
Journal: Gene
Title: Acetylation and deacetylation of non-histone proteins.
Volume: 363
Pages: 15-23
Publication
First Author: Di Giorgio E
Year: 2016
Journal: Epigenomics
Title: Regulation of class IIa HDAC activities: it is not only matter of subcellular localization.
Volume: 8
Issue: 2
Pages: 251-69
Publication
First Author: Kasler HG
Year: 2007
Journal: Mol Cell Biol
Title: Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes.
Volume: 27
Issue: 14
Pages: 5184-200
Publication
First Author: Mathias RA
Year: 2015
Journal: Mol Cell Proteomics
Title: Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease.
Volume: 14
Issue: 3
Pages: 456-70
Protein Domain
Type: Family
Description: Histone deacetylases (HDACs) modulate the acetylation level of histones to regulate chromatin structure and gene expression. They are considered to be crucial regulators of specific developmental and differentiation processes. Whilst they are primarily involved in the deacetylation of histones, they have also been shown to regulate the acetylation levels of non-histone proteins [].Class IIa histone deacetylases (HDACs4, -5, -6, -7, -9 and -10) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems [, [].HDAC4 performs a wide variety of functions, including the regulation of cell growth, survival and proliferation, and the regulation of gene transcription. It has been closely associated with the development of tumours in various tissues. It also induces demethylation of histone proteins, and has been shown to be subject to post-transcriptional modification by multiple methods []. HDAC4 has been reported to regulate chondrocyte hypertrophy and endochondral bone formation, muscle development, and cardiovascular diseases [].HDAC4 is localized to both the nucleus and cytoplasm, and undergoes subcellular shuttling in response to synaptic activity and environmental signals [, ]. It is important for neuronal development and function, and has been implicated in a number of neuronal diseases including brachydactyly mental retardation (BDMR) syndrome, ataxia telangiectasia, and Huntington's disease [].Histone deacetylase 7 (HDAC7) is highly expressed in double-positive thymocytes, suggesting a possible role in thymic T-cell development [, ].
Publication
First Author: Castets P
Year: 2019
Journal: Nat Commun
Title: mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4.
Volume: 10
Issue: 1
Pages: 3187
Publication
First Author: Pardo M
Year: 2017
Journal: JCI Insight
Title: Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice.
Volume: 2
Issue: 6
Pages: e91782
Publication
First Author: Dimitrakopoulos C
Year: 2021
Journal: BMC Genomics
Title: Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma.
Volume: 22
Issue: 1
Pages: 592
Publication
First Author: Liu R
Year: 2009
Journal: Cancer Res
Title: FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.
Volume: 69
Issue: 6
Pages: 2252-9
Publication
First Author: Han K
Year: 2013
Journal: Genes Dev
Title: Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p.
Volume: 27
Issue: 5
Pages: 485-90
Publication  
First Author: Moretti I
Year: 2016
Journal: Nat Commun
Title: MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
Volume: 7
Pages: 12397
Publication
First Author: Li J
Year: 2019
Journal: Nat Commun
Title: TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.
Volume: 10
Issue: 1
Pages: 1589
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
Publication
First Author: Backs J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.
Volume: 106
Issue: 7
Pages: 2342-7
Publication
First Author: Zhang CL
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis.
Volume: 98
Issue: 13
Pages: 7354-9
Publication
First Author: Yang Y
Year: 2014
Journal: PLoS One
Title: The interaction of the atm genotype with inflammation and oxidative stress.
Volume: 9
Issue: 1
Pages: e85863
Publication
First Author: Singh A
Year: 2013
Journal: J Clin Invest
Title: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis.
Volume: 123
Issue: 7
Pages: 2921-34
Publication
First Author: Bolger TA
Year: 2005
Journal: J Neurosci
Title: Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.
Volume: 25
Issue: 41
Pages: 9544-53
Publication
First Author: Ferry A
Year: 2014
Journal: Neuromuscul Disord
Title: Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers.
Volume: 24
Issue: 11
Pages: 960-72
Publication
First Author: Neuner SM
Year: 2017
Journal: Behav Brain Res
Title: Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models.
Volume: 322
Issue: Pt B
Pages: 288-298
Publication
First Author: Rogge GA
Year: 2013
Journal: J Neurosci
Title: HDAC3 is a negative regulator of cocaine-context-associated memory formation.
Volume: 33
Issue: 15
Pages: 6623-32
Publication
First Author: Huang ZP
Year: 2013
Journal: Circ Res
Title: MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.
Volume: 112
Issue: 9
Pages: 1234-43
Publication  
First Author: Zhao Y
Year: 2021
Journal: Front Physiol
Title: Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.
Volume: 12
Pages: 678863
Publication
First Author: Li M
Year: 2017
Journal: Biochim Biophys Acta
Title: Hepatic stellate cell-specific deletion of SIRT1 exacerbates liver fibrosis in mice.
Volume: 1863
Issue: 12
Pages: 3202-3211
Publication
First Author: Li LF
Year: 2017
Journal: PLoS One
Title: Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway.
Volume: 12
Issue: 2
Pages: e0172571
Publication
First Author: Lin X
Year: 2016
Journal: PLoS Genet
Title: MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in Mice.
Volume: 12
Issue: 10
Pages: e1006308
Publication
First Author: Sandhu SK
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.
Volume: 109
Issue: 49
Pages: 20047-52
Publication
First Author: McKinsey TA
Year: 2000
Journal: Nature
Title: Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
Volume: 408
Issue: 6808
Pages: 106-11
Publication
First Author: Lahm A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
Volume: 104
Issue: 44
Pages: 17335-40
Publication
First Author: Zhou X
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5.
Volume: 97
Issue: 3
Pages: 1056-61
Publication
First Author: Grozinger CM
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Volume: 96
Issue: 9
Pages: 4868-73
Publication
First Author: Imbriano C
Year: 2005
Journal: Mol Cell Biol
Title: Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.
Volume: 25
Issue: 9
Pages: 3737-51
Publication
First Author: Kishore AH
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Volume: 114
Issue: 31
Pages: E6427-E6436
Publication
First Author: Lin CL
Year: 2014
Journal: J Am Soc Nephrol
Title: MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction.
Volume: 25
Issue: 8
Pages: 1698-709
Publication
First Author: Sinnett-Smith J
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling.
Volume: 306
Issue: 10
Pages: C961-71
Publication  
First Author: Ravanelli F
Year: 2023
Journal: Int J Mol Sci
Title: Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study.
Volume: 24
Issue: 17
Publication  
First Author: Yang B
Year: 2020
Journal: J Mol Cell Cardiol
Title: Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome.
Volume: 138
Pages: 291-303
Publication  
First Author: Ling S
Year: 2018
Journal: Front Physiol
Title: Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.
Volume: 9
Pages: 40
Publication
First Author: Ko JY
Year: 2013
Journal: Bone
Title: MicroRNA-29a ameliorates glucocorticoid-induced suppression of osteoblast differentiation by regulating β-catenin acetylation.
Volume: 57
Issue: 2
Pages: 468-75
Publication  
First Author: Ko JY
Year: 2015
Journal: Bone
Title: MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation.
Volume: 81
Pages: 80-8
Publication
First Author: Nakatani T
Year: 2017
Journal: Endocrinology
Title: MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells.
Volume: 158
Issue: 11
Pages: 3778-3791
Publication
First Author: Chen C
Year: 2016
Journal: PLoS One
Title: Cyclic Equibiaxial Tensile Strain Alters Gene Expression of Chondrocytes via Histone Deacetylase 4 Shuttling.
Volume: 11
Issue: 5
Pages: e0154951
Publication  
First Author: Zhong G
Year: 2021
Journal: Front Cell Dev Biol
Title: WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity.
Volume: 9
Pages: 739944
Protein
Organism: Mus musculus/domesticus
Length: 1076  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 938  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 852  
Fragment?: true