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Search results 1 to 100 out of 348 for Shroom3

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0.037s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Protein Shroom3 (Shrm3) belongs to the Shroom family, whose members are linked to the actin cytoskeleton []. Shrm3 is an actin binding protein that directs Rho kinase- and RhoA-dependent apical constriction in the lens placode and partially facilitates invagination [, , , ]. It is recruited to adherens junctions by cadherin-binding ZA (zonula adherens) protein p120-catenin during lens pit morphogenesis []. It is necessary for neural tube closure in vertebrate development [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Plageman TF Jr
Year: 2010
Journal: Development
Title: Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.
Volume: 137
Issue: 3
Pages: 405-15
Publication
First Author: Lang RA
Year: 2014
Journal: Development
Title: p120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.
Volume: 141
Issue: 16
Pages: 3177-87
Publication
First Author: Nishimura T
Year: 2008
Journal: Development
Title: Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling.
Volume: 135
Issue: 8
Pages: 1493-502
GXD Expression
Probe: MGI:5811054
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5823715
Age: embryonic day 11.5
Image: S1A - Shroom3 - E11.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Shroom3 - E11.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5811054
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5823715
Age: embryonic day 10.5
Image: S1A - Shroom3 - E10.5
Note: This gene exhibits category 1 expression: staining is observed in the posterior/posterior-distal limb bud.
Specimen Label: S1A - Shroom3 - E10.5
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: human
Publication
First Author: Hildebrand JD
Year: 1999
Journal: Cell
Title: Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice.
Volume: 99
Issue: 5
Pages: 485-97
Publication
First Author: Das D
Year: 2014
Journal: Biol Open
Title: The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.
Volume: 3
Issue: 9
Pages: 850-60
Publication
First Author: Plageman TF Jr
Year: 2011
Journal: Dev Biol
Title: Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.
Volume: 357
Issue: 1
Pages: 227-34
Publication
First Author: Plageman TF Jr
Year: 2011
Journal: Development
Title: A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
Volume: 138
Issue: 23
Pages: 5177-88
Publication
First Author: Durbin MD
Year: 2020
Journal: Dev Biol
Title: SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.
Volume: 464
Issue: 2
Pages: 124-136
Publication
First Author: McGreevy EM
Year: 2015
Journal: Biol Open
Title: Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.
Volume: 4
Issue: 2
Pages: 186-96
Protein
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
Publication
First Author: Chu CW
Year: 2013
Journal: PLoS One
Title: Lulu regulates Shroom-induced apical constriction during neural tube closure.
Volume: 8
Issue: 11
Pages: e81854
Publication
First Author: Hildebrand JD
Year: 2005
Journal: J Cell Sci
Title: Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.
Volume: 118
Issue: Pt 22
Pages: 5191-203
Protein
Organism: Mus musculus/domesticus
Length: 1805  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1849  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1849  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1899  
Fragment?: false
Publication
First Author: Mohan S
Year: 2012
Journal: Mol Biol Cell
Title: Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
Volume: 23
Issue: 11
Pages: 2131-42
Protein
Organism: Mus musculus/domesticus
Length: 1986  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1980  
Fragment?: false
UniProt Feature
Begin: 1
Description: Protein Shroom3
Type: chain
End: 1986
Publication
First Author: Matsuura R
Year: 2020
Journal: Sci Rep
Title: SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure.
Volume: 10
Issue: 1
Pages: 21103
Publication
First Author: Loebel DA
Year: 2016
Journal: Biol Open
Title: Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction.
Volume: 5
Issue: 2
Pages: 130-9
Publication
First Author: Grosse AS
Year: 2011
Journal: Development
Title: Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
Volume: 138
Issue: 20
Pages: 4423-32
Publication
First Author: Pieters T
Year: 2020
Journal: BMC Dev Biol
Title: Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice.
Volume: 20
Issue: 1
Pages: 17
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication      
First Author: Niswander L
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2011/03/29
GXD Expression      
Probe: MGI:3037527
Assay Type: Western blot
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3037596
Age: embryonic day 12.5
Specimen Label: Shrm ++
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3037527
Assay Type: Western blot
Annotation Date: 2004-04-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:3037596
Age: embryonic day 12.5
Specimen Label: Shrm --
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7531374
Age: embryonic day 12.5
Image: 5
Specimen Label: Dishevelled2<+/+>
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7531374
Age: embryonic day 12.5
Image: 5
Specimen Label: Dishevelled2<+/->
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7531374
Age: embryonic day 12.5
Image: 5
Specimen Label: Dishevelled2<-/->
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7531382
Age: embryonic day 12.5
Image: 5
Specimen Label: Black bar
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:7531382
Age: embryonic day 12.5
Image: 5
Specimen Label: White bar
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732128
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal day 45
Image: S1
Specimen Label: P45 RA
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal day 45
Image: S1
Specimen Label: P45 LA
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734028
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal day 45
Image: S1
Specimen Label: P45 RV
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal day 45
Image: S1
Specimen Label: P45 LV
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1732128
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal year 1
Image: S1
Specimen Label: 1 yo RA
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1731528
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal year 1
Image: S1
Specimen Label: 1 yo LA
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1734028
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal year 1
Image: S1
Specimen Label: 1 yo RV
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7531180
Assay Type: RT-PCR
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Stage: TS28
Assay Id: MGI:7531406
Age: postnatal year 1
Image: S1
Specimen Label: 1 yo LA
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:6150049
Assay Type: RNA in situ
Annotation Date: 2018-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675215
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6150251
Age: embryonic day 9.5
Image: 1A
Note: Expression is seen as stripes in the anterior.
Specimen Label: 1A
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_06
Specimen Label: euxassay_012216_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_07
Specimen Label: euxassay_012216_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_08
Specimen Label: euxassay_012216_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_09
Specimen Label: euxassay_012216_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_10
Specimen Label: euxassay_012216_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_14
Specimen Label: euxassay_012216_14
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_15
Specimen Label: euxassay_012216_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:4423827
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828066
Age: embryonic day 14.5
Image: euxassay_012216_16
Specimen Label: euxassay_012216_16
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7531365
Age: postnatal day 7
Image: S1A
Specimen Label: S1A
Detected: true
Specimen Num: 13
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7531365
Age: postnatal day 21
Image: S1B
Specimen Label: S1B
Detected: true
Specimen Num: 14
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7531365
Age: postnatal month 3
Image: S1C
Specimen Label: S1C
Detected: true
Specimen Num: 15
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7531365
Age: postnatal month 9
Image: S1D
Specimen Label: S1D
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7531365
Age: embryonic day 12.5
Image: 1F
Specimen Label: 1F
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6113280
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7486722
Age: embryonic day 10.5
Image: S3E/F
Note: Localized mostly to the zonula adherens and did not appear to strongly colocalize with Ctnnd1 in prominent actomyosin filaments that spanned the apical cortex.
Specimen Label: S3E/F
Detected: true
Specimen Num: 7
GXD Expression
Probe: MGI:6113280
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7486722
Age: embryonic day 10.5
Image: 5H
Note: Quantifiably reduced in the apical junctions of hinge point cells, but apical localization in the central portion of the lens pit is unchanged.
Specimen Label: 5H
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6113280
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:7486722
Age: embryonic day 10.5
Image: 5I
Note: Significant reduction in both hinge point and central cells.
Specimen Label: 5I
Detected: true
Specimen Num: 3
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689518
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2B left
Detected: true
Specimen Num: 2
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689518
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2B right
Detected: true
Specimen Num: 3
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3037557
Age: embryonic day 14.5
Specimen Label: 2D
Detected: true
Specimen Num: 5
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2H
Detected: true
Specimen Num: 9
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2H
Detected: true
Specimen Num: 9
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2I
Detected: true
Specimen Num: 10
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3037557
Age: embryonic day 10.5
Specimen Label: 2J
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:5811054
Assay Type: RNA in situ
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668115
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7531362
Age: embryonic day 9.5
Image: 1A
Specimen Label: 1A
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2023-09-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1668115
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:7531365
Age: embryonic day 9.5
Image: 1B
Specimen Label: 1B
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2004-04-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185718
Pattern: Regionally restricted
Stage: TS18
Assay Id: MGI:3037557
Age: embryonic day 10.5
Note: Expression was detected in the ventral body wall.
Specimen Label: 2B left
Detected: true
Specimen Num: 2