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Search results 201 to 227 out of 227 for Pals1

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Type

Details

Score

HT Experiment

E-GEOD-75696 | Apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state

Series Id:	GSE75696
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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GXD Expression

Probe:	MGI:6393426
Assay Type:	Immunohistochemistry
Annotation Date:	2020-03-06
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:1754422
Pattern:	Regionally restricted
Stage:	TS22
Assay Id:	MGI:6393436
Age:	embryonic day 14.5
Image:	4G MUPP1 (upper)
Note:	Expression fully colocalized with Pals1 (Mpp5).
Specimen Label:	4G MUPP1 (upper)
Detected:	true
Specimen Num:	4

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GXD Expression

Probe:	MGI:6393426
Assay Type:	Immunohistochemistry
Annotation Date:	2020-03-06
Strength:	Present
Sex:	Not Specified
Emaps:	EMAPS:1754722
Pattern:	Regionally restricted
Stage:	TS22
Assay Id:	MGI:6393436
Age:	embryonic day 14.5
Image:	4G MUPP1 (lower)
Note:	Expression fully colocalized with Pals1 (Mpp5).
Specimen Label:	4G MUPP1 (lower)
Detected:	true
Specimen Num:	5

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Publication

21479189 | -

First Author:	Carvalho G
Year:	2011
Journal:	PLoS One
Title:	Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
Volume:	6
Issue:	3
Pages:	e18159

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Publication

25385611 | -

First Author:	Li Y
Year:	2014
Journal:	Proc Natl Acad Sci U S A
Title:	Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.
Volume:	111
Issue:	49
Pages:	17444-9

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Publication

20861307 | -

First Author:	Teoh KT
Year:	2010
Journal:	Mol Biol Cell
Title:	The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Volume:	21
Issue:	22
Pages:	3838-52

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Publication

12545177 | -

First Author:	Hurd TW
Year:	2003
Journal:	Nat Cell Biol
Title:	Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
Volume:	5
Issue:	2
Pages:	137-42

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Publication

15140881 | -

First Author:	Wang Q
Year:	2004
Journal:	J Biol Chem
Title:	Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.
Volume:	279
Issue:	29
Pages:	30715-21

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Publication

15558731 | -

First Author:	Stöhr H
Year:	2005
Journal:	J Comp Neurol
Title:	Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.
Volume:	481
Issue:	1
Pages:	31-41

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Publication

12527193 | -

First Author:	Makarova O
Year:	2003
Journal:	Gene
Title:	Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
Volume:	302
Issue:	1-2
Pages:	21-9

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Publication

11992120 | -

First Author:	Wei X
Year:	2002
Journal:	Nat Genet
Title:	nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina.
Volume:	31
Issue:	2
Pages:	150-7

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Protein Domain

IPR031185 | MPP5-like

Type:

Family

Description:

This family includes MAGUK p55 subfamily member 5 and related proteins.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].Membrane-associated guanylate kinase (MAGUK) p55 subfamily member 5 (MPP5, also known as PALS1 or Stardust in Drosophila) plays a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells [, ]. Zebrafish MPP5A is essential for cellular patterning of the retina [].

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Publication

20362667 | -

First Author:	Yamaguchi M
Year:	2010
Journal:	Mech Dev
Title:	Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina.
Volume:	127
Issue:	5-6
Pages:	247-64

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Publication

20861315 | -

First Author:	Bulgakova NA
Year:	2010
Journal:	Mol Biol Cell
Title:	Antagonistic functions of two stardust isoforms in Drosophila photoreceptor cells.
Volume:	21
Issue:	22
Pages:	3915-25

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Publication

28416478 | -

First Author:	Das S
Year:	2017
Journal:	J Cell Biol
Title:	Stardust, the Janus-faced partner of Crumbs.
Volume:	216
Issue:	5
Pages:	1219-1221

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Protein Domain

IPR035601 | MPP5_SH3

Type:

Domain

Description:

MPP5, also called PALS1 (protein associated with Lin7) or Nagie oko protein in zebrafish []or Stardust in Drosophila [], is a scaffolding protein which associates with Crumbs homologue 1 (CRB1), CRB2, or CRB3 through its PDZ domain and with PALS1-associated tight junction protein (PATJ) or multi-PDZ domain protein 1 (MUPP1) through its L27 domain []. The resulting tri-protein complexes are core proteins of the Crumb complex, which localizes at tight junctions or subapical regions, and is involved in the maintenance of apical-basal polarity in epithelial cells and the morphogenesis and function of photoreceptor cells []. MPP5 is critical for the proper stratification of the retina and is also expressed in T lymphocytes where it is important for TCR-mediated activation of NFkB []. Drosophila Stardust exists in several isoforms, some of which show opposing functions in photoreceptor cells, which suggests that the relative ratio of different Crumbs complexes regulates photoreceptor homeostasis []. MPP5 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain [].

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Publication

28500065 | J:250134

First Author:	Feldner A
Year:	2017
Journal:	EMBO Mol Med
Title:	Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice.
Volume:	9
Issue:	7
Pages:	890-905

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Publication

12771187 | J:84636

First Author:	Roh MH
Year:	2003
Journal:	J Cell Sci
Title:	The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.
Volume:	116
Issue:	Pt 14
Pages:	2895-906

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Publication

16098509 | J:102605

First Author:	Satohisa S
Year:	2005
Journal:	Exp Cell Res
Title:	Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization.
Volume:	310
Issue:	1
Pages:	66-78

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Publication

17012742 | J:117632

First Author:	Straight SW
Year:	2006
Journal:	J Biol Chem
Title:	Mammalian lin-7 stabilizes polarity protein complexes.
Volume:	281
Issue:	49
Pages:	37738-47

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Publication

24112238 | J:215425

First Author:	Yamada T
Year:	2013
Journal:	Genes Cells
Title:	Nectin and junctional adhesion molecule are critical cell adhesion molecules for the apico-basal alignment of adherens and tight junctions in epithelial cells.
Volume:	18
Issue:	11
Pages:	985-98

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Publication

27521426 | J:246812

First Author:	Campbell CI
Year:	2016
Journal:	J Cell Sci
Title:	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.
Volume:	129
Issue:	18
Pages:	3396-411

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Publication

11414766 | -

First Author:	Stöhr H
Year:	2001
Journal:	Genomics
Title:	Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins.
Volume:	74
Issue:	3
Pages:	377-84

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Publication

17678554 | -

First Author:	te Velthuis AJ
Year:	2007
Journal:	BMC Evol Biol
Title:	Molecular evolution of the MAGUK family in metazoan genomes.
Volume:	7

Pages:	129

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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