Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 136 out of 136 for Atg14

<< First < Previous | Next > Last >>

0.022s

Type

Details

Score

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

18843052 | -

First Author:	Itakura E
Year:	2008
Journal:	Mol Biol Cell
Title:	Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Volume:	19
Issue:	12
Pages:	5360-72

•

Publication

25686604 | -

First Author:	Diao J
Year:	2015
Journal:	Nature
Title:	ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Volume:	520
Issue:	7548
Pages:	563-6

•

Publication

26450213 | -

First Author:	Rostislavleva K
Year:	2015
Journal:	Science
Title:	Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Volume:	350
Issue:	6257
Pages:	aac7365

•

Publication

12244127 | -

First Author:	Burda P
Year:	2002
Journal:	J Cell Sci
Title:	Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.
Volume:	115
Issue:	Pt 20
Pages:	3889-900

•

Protein Domain

IPR040939 | Vps38

Type:

Family

Description:

This entry includes Vps38 from budding yeasts. Vps38 is involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II [].The class III phosphatidylinositol-3-kinase (PI3K) known as Vps34 regulates intracellular membrane trafficking in endocytic sorting, cytokinesis and autophagy. Vps34 forms complexes with other proteins: Vps15, Vps30 (encoded by VPS30/ATG6 in yeast, equivalent to mammalian Beclin 1, encoded by BECN1) and either Vps38 (UVRAG) or Atg14 (ATG14L). Although the N-terminal domains of Vps30, Vps38 and Atg14 differ, the overall similarity of their domain organizations suggests that these proteins may have evolved from a common ancestor [].

•

Protein

Q8CDJ3

Organism:	Mus musculus/domesticus
Length:	492
Fragment?:	false

•

Protein

Q9QYL9

Organism:	Mus musculus/domesticus
Length:	337
Fragment?:	true

•

Publication

19050071 | -

First Author:	Sun Q
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Volume:	105
Issue:	49
Pages:	19211-6

•

Publication

16799551 | -

First Author:	Liang C
Year:	2006
Journal:	Nat Cell Biol
Title:	Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Volume:	8
Issue:	7
Pages:	688-99

•

Protein Domain

IPR018791 | UV_resistance/autophagy_Atg14

Type:

Family

Description:

This entry includes Atg14 (autophagy-related protein 14) from budding yeasts, Vps38 from fission yeasts and their homologues, Atg14L/Bakor (beclin-1-associated autophagy-related key regulator) and UVRAG (UV irradiation resistance-associated gene), from animals. Atg14 is a hydrophilic protein with a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole [].Barkor positively regulates autophagy through its interaction with Beclin-1, with decreased levels of autophagosome formation observed when Barkor expression is eliminated []. UVRAG is also a Beclin1 binding protein that positively stimulate starvation-induced autophagy []. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15, Vps30/Atg6, and Atg14) is involved in autophagy, andcomplex II (Vps34, Vps15, Vps30/Atg6, and Vps38) functions in the vacuolar protein sorting pathway []. In mammals, complex II is also involved in autophagy []. The mammalian counterparts of Vps34, Vps15, and Vps30/Atg6 are Vps34, p150, and Beclin 1, respectively, and UV irradiation resistance-associated gene (UVRAG) has been identified as identical to yeast Vps38 [].

•

Publication

11157979 | -

First Author:	Kihara A
Year:	2001
Journal:	J Cell Biol
Title:	Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
Volume:	152
Issue:	3
Pages:	519-30

•

Publication

26687681 | J:232813

First Author:	Liu CC
Year:	2016
Journal:	Mol Cell
Title:	Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.
Volume:	61
Issue:	1
Pages:	84-97

•

Publication

9712845 | -

First Author:	Kametaka S
Year:	1998
Journal:	J Biol Chem
Title:	Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
Volume:	273
Issue:	35
Pages:	22284-91

•

Publication

20643123 | -

First Author:	Thoresen SB
Year:	2010
Journal:	Exp Cell Res
Title:	A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Volume:	316
Issue:	20
Pages:	3368-78

•

Protein Domain

IPR038274 | Atg6/Beclin_C_sf

Type:

Homologous_superfamily

Description:

In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 links Vps30 to Vps34 and plays an important role in vacuolar protein sorting []. The C-terminal of Vps30 contains a globular fold comprised of three β-sheet-α-helix repeats (also known as beta-alpha repeated, autophagy-specific (BARA) domain) and is required for autophagy through the targeting of complex I to the pre-autophagosomal structure. The N-terminal of Vps30 is required for vacuolar protein sorting []. Beclin, the mammalian homologue of yeast Atg6/Vps30, isa tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [, ].

•

Protein Domain

IPR007243 | Atg6/Beclin

Type:

Family

Description:

In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 links Vps30 to Vps34 and plays an important role in vacuolar protein sorting []. The C-terminal of Vps30 contains a globular fold comprised of three β-sheet-α-helix repeats (also known as beta-alpha repeated, autophagy-specific (BARA) domain) and is required for autophagy through the targeting of complex I to the pre-autophagosomal structure. The N-terminal of Vps30 is required for vacuolar protein sorting []. Beclin, the mammalian homologue of yeast Atg6/Vps30, is a tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [, ].

•

Publication

22437838 | -

First Author:	Noda NN
Year:	2012
Journal:	J Biol Chem
Title:	Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.
Volume:	287
Issue:	20
Pages:	16256-66

•

Publication

29317496 | J:262334

First Author:	Croft T
Year:	2018
Journal:	J Biol Chem
Title:	A functional link between NAD⁺ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae.
Volume:	293
Issue:	8
Pages:	2927-2938

•

Publication

33495338 | J:302581

First Author:	Wijshake T
Year:	2021
Journal:	Proc Natl Acad Sci U S A
Title:	Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
Volume:	118
Issue:	5

•

Protein

Q8K245

Organism:	Mus musculus/domesticus
Length:	698
Fragment?:	false

•

Protein

Q8BJ94

Organism:	Mus musculus/domesticus
Length:	465
Fragment?:	false

•

Protein

Q8BXW8

Organism:	Mus musculus/domesticus
Length:	698
Fragment?:	false

•

Protein

F7CVL9

Organism:	Mus musculus/domesticus
Length:	125
Fragment?:	true

•

Publication

22170155 | -

First Author:	Wirawan E
Year:	2012
Journal:	Autophagy
Title:	Beclin1: a role in membrane dynamics and beyond.
Volume:	8
Issue:	1
Pages:	6-17

•

Protein

E9PX06

Organism:	Mus musculus/domesticus
Length:	46
Fragment?:	false

•

Protein

F7DB15

Organism:	Mus musculus/domesticus
Length:	110
Fragment?:	true

•

Protein

E9QAM0

Organism:	Mus musculus/domesticus
Length:	105
Fragment?:	false

•

Protein

O88597

Organism:	Mus musculus/domesticus
Length:	448
Fragment?:	false

•

Protein

P0DM65

Organism:	Mus musculus/domesticus
Length:	447
Fragment?:	false

•

Protein

A0A0J9YUN7

Organism:	Mus musculus/domesticus
Length:	442
Fragment?:	false

•

Protein

E9PYD6

Organism:	Mus musculus/domesticus
Length:	277
Fragment?:	false

•

Publication

21311563 | -

First Author:	Kang R
Year:	2011
Journal:	Cell Death Differ
Title:	The Beclin 1 network regulates autophagy and apoptosis.
Volume:	18
Issue:	4
Pages:	571-80

•

Protein

F7C090

Organism:	Mus musculus/domesticus
Length:	168
Fragment?:	true

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=BE438B7753B4693E7FDED9226747E706?searchTerm=Atg14&searchBag=&searchOffset=100

MouseMine

Search our database by keyword

Examples

Search results 101 to 136 out of 136 for Atg14

Categories

Hits by Pathway

Hits by Strain

Hits by Category