TFCP2 (CP2 transcription factor) is a critical regulator of erythroid gene expression [, ]. It also regulates the expressison of the male-dominant sex-determining gene SRY []. TFCP2 can interact with NF-E4 proteins forming heteromeric stage selector protein complex (SSP); this complex is able to bind stage selector element (SSE) and regulate embryonic globin expression in fetal-erythroid cells [].TFCP2 has an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and a C-terminal dimerization domain. This entry represents the SAM domain.
