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Search results 501 to 560 out of 560 for Trim25

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
108700943 | LOC108700943
Type: gene
Organism: frog, African clawed
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Gene
108701186 | LOC108701186
Type: gene
Organism: frog, African clawed
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Gene
108701187 | LOC108701187
Type: gene
Organism: frog, African clawed
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Gene
108701629 | LOC108701629
Type: gene
Organism: frog, African clawed
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Gene
108701681 | LOC108701681
Type: gene
Organism: frog, African clawed
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Gene
108701816 | LOC108701816
Type: gene
Organism: frog, African clawed
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Gene
108701916 | LOC108701916
Type: gene
Organism: frog, African clawed
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Gene
108702044 | LOC108702044
Type: gene
Organism: frog, African clawed
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Gene
108702045 | LOC108702045
Type: gene
Organism: frog, African clawed
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Gene
108702375 | LOC108702375
Type: gene
Organism: frog, African clawed
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Gene
108702387 | LOC108702387
Type: gene
Organism: frog, African clawed
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Gene
108702435 | LOC108702435
Type: gene
Organism: frog, African clawed
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Gene
108702642 | LOC108702642
Type: gene
Organism: frog, African clawed
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Gene
108702663 | LOC108702663
Type: gene
Organism: frog, African clawed
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Gene
108702921 | LOC108702921
Type: gene
Organism: frog, African clawed
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Gene
108703759 | LOC108703759
Type: gene
Organism: frog, African clawed
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Gene
108703762 | LOC108703762
Type: gene
Organism: frog, African clawed
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Gene
108703916 | LOC108703916
Type: gene
Organism: frog, African clawed
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Gene
108704228 | LOC108704228
Type: gene
Organism: frog, African clawed
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Gene
108704418 | LOC108704418
Type: gene
Organism: frog, African clawed
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Gene
108704420 | LOC108704420
Type: gene
Organism: frog, African clawed
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Gene
108704611 | LOC108704611
Type: gene
Organism: frog, African clawed
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Gene
108704996 | LOC108704996
Type: gene
Organism: frog, African clawed
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Gene
108706478 | LOC108706478
Type: gene
Organism: frog, African clawed
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Gene
108707587 | LOC108707587
Type: gene
Organism: frog, African clawed
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Gene
108708928 | LOC108708928
Type: gene
Organism: frog, African clawed
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Gene
108709303 | LOC108709303
Type: gene
Organism: frog, African clawed
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Gene
108712554 | LOC108712554
Type: gene
Organism: frog, African clawed
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Gene
108718871 | LOC108718871
Type: gene
Organism: frog, African clawed
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Gene
108719103 | LOC108719103
Type: gene
Organism: frog, African clawed
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Gene
108719124 | LOC108719124
Type: gene
Organism: frog, African clawed
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Gene
108719243 | LOC108719243
Type: gene
Organism: frog, African clawed
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Gene
432183 | LOC432183
Type: gene
Organism: frog, African clawed
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Protein
Q5SU71
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q5SU72
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Publication
17392790 | -
First Author: Gack MU
Year: 2007
Journal: Nature
Title: TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Volume: 446
Issue: 7138
Pages: 916-920
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Allele
Trp53inp1<em1Smoc> | MGI:7292995
Name: transformation related protein 53 inducible nuclear protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
DCruz AA (2013)
Description: Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling.
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Publication
29259080 | -
First Author: D'Cruz AA
Year: 2018
Journal: Biochem J
Title: Identification of a second binding site on the TRIM25 B30.2 domain.
Volume: 475
Issue: 2
Pages: 429-440
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Strain
MGI:6476537 | C57BL/6-Trim25<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Trim25<em1Smoc> | MGI:7292972
Name: tripartite motif-containing 25; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Domain
IPR042753 | TRIM25_SPRY_PRY
Type: Domain
Description: This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM25 proteins. TRIM25 (also called Efp) ubiquitinates the N terminus of the viral RNA receptor retinoic acid-inducible gene-I (RIG-I) in response to viral infection, leading to activation of the RIG-I signalling pathway, thus resulting in type I interferon production to limit viral replication. It has been shown that the influenza A virus targets TRIM25 and disables its antiviral function [, ].
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Publication
19017631 | -
First Author: Oshiumi H
Year: 2009
Journal: J Biol Chem
Title: Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Volume: 284
Issue: 2
Pages: 807-17
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Publication
17632510 | -
First Author: Douglas J
Year: 2007
Journal: Nat Genet
Title: Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.
Volume: 39
Issue: 8
Pages: 963-5
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Publication
31065957 | -
First Author: Zhang D
Year: 2019
Journal: Biomol NMR Assign
Title: Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Volume: 13
Issue: 2
Pages: 299-304
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Protein Domain
IPR042723 | RNF135_SPRY_PRY_dom
Type: Domain
Description: This entry represents the C-terminal domain of RING finger protein RNF135. This domain contains the distinct N-terminal PRY subdomain followed by the SPRY subdomain. RNF135 ubiquitinates RIG-I (retinoic acid-inducible gene-I) to promote interferon-beta induction during the early phase of viral infection. Normally, RIG-I is activated by TRIM25 in response to viral infection, leading to activation of the RIG-I signalling pathway, thus resulting in type I interferon production to limit viral replication. However, RNF135, consisting of an N-terminal RING finger domain, C-terminal SPRY and PRY motifs and showing sequence similarity to TRIM25, acts as an alternative factor that promotes RIG-I activation independent of TRIM25 []. RNF135 interacts with RIG-I via the PRY-SPRY domain []. Mutations of the RNF135 gene cause phenotypic abnormalities including overgrowth [].
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Publication
30193849 | J:268028
First Author: Lian H
Year: 2018
Journal: Immunity
Title: The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.
Volume: 49
Issue: 3
Pages: 438-448.e5
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Publication
31036902 | J:282488
First Author: Lin H
Year: 2019
Journal: Nat Immunol
Title: The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response.
Volume: 20
Issue: 7
Pages: 812-823
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Publication
33436560 | J:300886
First Author: Li B
Year: 2021
Journal: Nat Commun
Title: circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.
Volume: 12
Issue: 1
Pages: 295
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Publication
34313226 | J:308289
   
First Author: Yang Z
Year: 2021
Journal: Elife
Title: RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.
Volume: 10
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Publication
31843969 | J:285825
First Author: Jureka AS
Year: 2020
Journal: J Biol Chem
Title: The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
Volume: 295
Issue: 4
Pages: 1153-1164
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Publication
23950712 | J:261333
First Author: Oshiumi H
Year: 2013
Journal: PLoS Pathog
Title: A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
Volume: 9
Issue: 8
Pages: e1003533
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Publication
29472715 | J:303326
First Author: Zhenilo S
Year: 2018
Journal: Cell Death Differ
Title: DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress.
Volume: 25
Issue: 11
Pages: 1938-1951
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Protein
Q3TU94
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: false
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Protein
Q3U3X7
Organism: Mus musculus/domesticus
Length: 634  
Fragment?: false
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Protein
Q9CWS1
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Protein
B2RRA5
Organism: Mus musculus/domesticus
Length: 417  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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