KCMF1 (potassium channel modulatory factor 1), also known as FIGC, has been identified as a ubiquitin-protein ligase that is up-regulated in response to bFGF in gastric cancer [].
This zinc-binding domain is found in plant drought induced 19 (Di19) proteins, animal E3 ubiquitin-protein ligases (RNF114/KCMF1/RNF138/RNF125) and transcriptional repressors (ZEB1/ZEB2). Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought []. KCMF1 and RNF114 are E3 ubiquitin-protein ligases [, ], while ZEB1 represses transcription by binding to the E box (5'-CANNTG-3') [].
