|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 282 out of 282 for Lig4

<< First    < Previous  |  Next >    Last >>
0.024s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
12846809 | J:85021
 
First Author: Mills KD
Year: 2003
Journal: Immunol Rev
Title: The role of DNA breaks in genomic instability and tumorigenesis.
Volume: 194
Pages: 77-95
•
•
•
•
•
Publication
21390131 | J:170077
First Author: Gao Y
Year: 2011
Journal: Nature
Title: DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair.
Volume: 471
Issue: 7337
Pages: 240-4
•
•
•
•
•
Publication
30022158 | J:265299
First Author: Mirman Z
Year: 2018
Journal: Nature
Title: 53BP1-RIF1-shieldin counteracts DSB resection through CST- and PolĪ±-dependent fill-in.
Volume: 560
Issue: 7716
Pages: 112-116
•
•
•
•
•
Publication
11040211 | J:65540
First Author: Lee Y
Year: 2000
Journal: Genes Dev
Title: Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm.
Volume: 14
Issue: 20
Pages: 2576-80
•
•
•
•
•
Publication
22670056 | J:185501
First Author: Foster SS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.
Volume: 109
Issue: 25
Pages: 9953-8
•
•
•
•
•
Publication
16777961 | J:111068
First Author: Orii KE
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.
Volume: 103
Issue: 26
Pages: 10017-22
•
•
•
•
•
Publication
24886500 | J:213574
 
First Author: Wang XQ
Year: 2014
Journal: BMC Dev Biol
Title: G1 checkpoint establishment in vivo during embryonic liver development.
Volume: 14
Pages: 23
•
•
•
•
•
Publication
16565260 | J:109514
First Author: Vats KR
Year: 2006
Journal: J Am Soc Nephrol
Title: A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34.
Volume: 17
Issue: 4
Pages: 1158-67
•
•
•
•
•
Publication
26290337 | J:226703
First Author: Shimada M
Year: 2015
Journal: EMBO J
Title: Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.
Volume: 34
Issue: 19
Pages: 2465-80
•
•
•
•
•
Publication
24899707 | J:211631
First Author: Lee Y
Year: 2014
Journal: J Neurosci
Title: Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.
Volume: 34
Issue: 23
Pages: 7836-44
•
•
•
•
•
Publication
19076778 | J:173443
First Author: Huse JT
Year: 2009
Journal: Brain Pathol
Title: Genetically engineered mouse models of brain cancer and the promise of preclinical testing.
Volume: 19
Issue: 1
Pages: 132-43
•
•
•
•
•
Publication
22522401 | J:191367
First Author: Lee Y
Year: 2012
Journal: Nat Neurosci
Title: Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.
Volume: 15
Issue: 6
Pages: 819-26
•
•
•
•
•
Publication
- | J:104190
     
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
•
•
•
•
•
Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6358696
Assay Type: Immunohistochemistry
Annotation Date: 2019-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6358709
Age: embryonic day 15.5
Note: Large diffuse apoptotic foci.
Specimen Label: 2B Lig4 Nes-Cre gH2AX
Detected: true
Specimen Num: 3
•
•
•
•
•
Allele
Lig4<tm1Smoc> | MGI:7290825
Name: ligase IV, DNA, ATP-dependent; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Lig4<tiny> | MGI:3714783
Name: ligase IV, DNA, ATP-dependent; tiny
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph
•
•
•
•
•
Allele
Lig4<tm2.1Fwa> | MGI:4437270
Name: ligase IV, DNA, ATP-dependent; targeted mutation 2.1, Frederick W Alt
Allele Type: Targeted
Attribute String: Humanized sequence
•
•
•
•
•
GO Term
GO:0070419 | nonhomologous end joining complex
•
•
•
•
•
Strain
MGI:6429110 | C57BL/6J-Lig4<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Lig4/Lig4
Background: C57BL/6-Lig4
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Lig4/Lig4
Background: involves: 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Allele
Lig4<m1Btlr> | MGI:6269393
Name: ligase IV, DNA, ATP-dependent; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
•
•
•
•
•
Strain
MGI:6269394 | C57BL/6J-Lig4<m1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
•
•
•
•
•
Allele
Lig4<m2Btlr> | MGI:6269402
Name: ligase IV, DNA, ATP-dependent; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
•
•
•
•
•
Strain
MGI:6269403 | C57BL/6J-Lig4<m2Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
•
•
•
•
•
Genotype
Genotype
Symbol: Lig4/Lig4
Background: C57BL/6J-Lig4
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Lig4/Lig4
Background: C57BL/6J-Lig4
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR021536 | DNA_ligase_IV_dom
Type: Domain
Description: This entry represents the DNA ligase IV (Lig4) sequences between the two BRCA1 C-terminal (BRCT) domains. Lig4 along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface [].
•
•
•
•
•
Publication
12517771 | -
First Author: Lee JW
Year: 2003
Journal: Cancer Res
Title: Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.
Volume: 63
Issue: 1
Pages: 22-4
•
•
•
•
•
Publication
11029705 | -
First Author: West CE
Year: 2000
Journal: Plant J
Title: Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4.
Volume: 24
Issue: 1
Pages: 67-78
•
•
•
•
•
Publication
14551247 | -
First Author: Catlett MG
Year: 2003
Journal: Mol Biol Cell
Title: Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.
Volume: 14
Issue: 11
Pages: 4707-20
•
•
•
•
•
Publication
9590697 | -
First Author: Petukhova G
Year: 1998
Journal: Nature
Title: Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins.
Volume: 393
Issue: 6680
Pages: 91-4
•
•
•
•
•
Publication
12453424 | -
First Author: Solinger JA
Year: 2002
Journal: Mol Cell
Title: Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filaments.
Volume: 10
Issue: 5
Pages: 1175-88
•
•
•
•
•
Protein Domain
IPR010585 | DNA_repair_prot_XRCC4
Type: Family
Description: This entry represents the DNA double-strand break repair and V(D)J recombination protein XRCC4, which is found in certain Metazoans, fungi and plants. XRCC4 binds to DNA, and to DNA ligase IV (LIG4) to form the LIG4-XRCC4 complex []. The LIG4-XRCC4 complex is responsible for the ligation step in the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. XRCC4 enhances the joining activity of LIG4. It is thought that XRCC4 and LIG4 are essential for alignment-based gap filling, as well as for final ligation of the breaks []. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
•
•
•
•
•
Protein Domain
IPR013967 | Rad54_N
Type: Domain
Description: This is the N-terminal of the DNA repair protein Rad54 []. Rad54 functions in the recombinational DNA repair (RAD52) pathway. It dissociates RAD51 from nucleoprotein filaments formed on dsDNA and could be involved in the turnover of RAD51 protein-dsDNA filaments. Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. LIG4 and RAD54L cooperate to support cellular proliferation, repair spontaneous DSBs, and prevent chromosome and single chromatid aberrations [, ].
•
•
•
•
•
Publication
28051062 | J:238544
 
First Author: Liu X
Year: 2017
Journal: Nat Commun
Title: PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.
Volume: 8
Pages: 13816
•
•
•
•
•
Publication
20362325 | J:240590
First Author: Bunting SF
Year: 2010
Journal: Cell
Title: 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
Volume: 141
Issue: 2
Pages: 243-54
•
•
•
•
•
Publication
23567907 | J:315249
 
First Author: Li H
Year: 2013
Journal: Mutat Res
Title: Ku80-deleted cells are defective at base excision repair.
Volume: 745-746
Pages: 16-25
•
•
•
•
•
Protein Coding Gene
MGI:2442831 | Paxx
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
E0CZC8
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
•
•
•
•
•
Protein
E0CY05
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
•
•
•
•
•
Publication
11702069 | -
First Author: Sibanda BL
Year: 2001
Journal: Nat Struct Biol
Title: Crystal structure of an Xrcc4-DNA ligase IV complex.
Volume: 8
Issue: 12
Pages: 1015-9
•
•
•
•
•
Protein Coding Gene
MGI:1922820 | Nhej1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein
Q924T3
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J1Y0
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J024
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:2441769 | Dclre1c
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:104517 | Xrcc5
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:1333799 | Xrcc4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:95606 | Xrcc6
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI:104779 | Prkdc
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom