This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs []. The first domain may be involved in RyR2 dimerization [].
This SPRY domain is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs [].
