Pbx proteins are members of the TALE (three-amino-acid loop extension) family of atypical homeodomain proteins, whose membersare characterised by a three-residue insertion between helix 1 and 2 and plays essential roles during embryonic development by participating in interactive TF networks. The heterodimerization of TALE proteins serves as a trigger for precise execution of developmental programs. Examinationof Pbx1 has shown that, in addition to the homeodomain, a short 16-residue C-terminal tail is essential for maximal cooperative interactions withHox partners as well as for maximal monomeric binding of Pbx1 to DNA. The PCB domain is a bipartite acidic domain that can be further subdivided into an A and B region [, , ].
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3 or BAF60C) is a component of several complexes that remodel chromatin, a mechanism by which selected genes are transcriptionally activated or repressed. The complexes are SWI/SNF, which changes chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner []; BAF []; and the npBAF and nBAF, which are neuron-specific []. SMARCD3 is known to interact with a number of proteins, including SMARCA4/BRG1/BAF190A []and the homeobox protein PBX1 [].
