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Search results 201 to 229 out of 229 for Pabpc1

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0.019s

Type

Details

Score

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

34143182 | J:309040

First Author:	Li K
Year:	2021
Journal:	J Exp Med
Title:	E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
Volume:	218
Issue:	8

•

HT Experiment

E-GEOD-39640 | ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice

Series Id:	GSE39640
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

23340509 | J:245279

First Author:	Huang KL
Year:	2013
Journal:	RNA
Title:	Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate.
Volume:	19
Issue:	3
Pages:	295-305

•

Publication

26912148 | -

First Author:	Stupfler B
Year:	2016
Journal:	Nat Commun
Title:	BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.
Volume:	7

Pages:	10811

•

Publication

19797087 | -

First Author:	Zekri L
Year:	2009
Journal:	Mol Cell Biol
Title:	The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.
Volume:	29
Issue:	23
Pages:	6220-31

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Ontology Term

- | Decay of host mRNAs by virus

•

Ontology Term

- | Inhibition of host poly(A)-binding protein by virus

•

Protein Domain

IPR033503 | GW182

Type:	Family
Description:	Protein Gawky (also known as GW182) plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs) [, ]. It is a component of cytoplasmic mRNA processing bodies required for early Drosophila development []. GW182 interacts with AGO1, and this interaction is essential for silencing by miRNAs []. It recruits the CCR4-NOT deadenylase complex through the interaction with PABPC1 [].

•

Publication

16177138 | -

First Author:	Rehwinkel J
Year:	2005
Journal:	RNA
Title:	A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.
Volume:	11
Issue:	11
Pages:	1640-7

•

Publication

19304924 | -

First Author:	Chekulaeva M
Year:	2009
Journal:	RNA
Title:	Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila.
Volume:	15
Issue:	5
Pages:	794-803

•

Publication

16880270 | -

First Author:	Schneider MD
Year:	2006
Journal:	J Cell Biol
Title:	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.
Volume:	174
Issue:	3
Pages:	349-58

•

Publication

18345015 | -

First Author:	Eulalio A
Year:	2008
Journal:	Nat Struct Mol Biol
Title:	GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay.
Volume:	15
Issue:	4
Pages:	346-53

•

Protein Domain

IPR041971 | Gawky_UBA

Type:

Domain

Description:

This entry represents the UBA domain of Gawky.Protein Gawky (also known as GW182) plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs) [, ]. It is a component of cytoplasmic mRNA processing bodies required for early Drosophila development []. GW182 interacts with AGO1, and this interaction is essential for silencing by miRNAs []. It recruits the CCR4-NOT deadenylase complex through the interaction with PABPC1 [].

•

HT Experiment

E-GEOD-55177 | Ataxin-2 adapts ribosomal mRNA levels and S6 phosphorylation to nutrient availability, with effects on protein synthesis and growth

Series Id:	GSE55177
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

26971890 | J:319556

First Author:	Kashiwabara S
Year:	2016
Journal:	J Reprod Dev
Title:	Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.
Volume:	62
Issue:	3
Pages:	305-10

•

Publication

16418486 | -

First Author:	Boiko AD
Year:	2006
Journal:	Genes Dev
Title:	A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation.
Volume:	20
Issue:	2
Pages:	236-52

•

Protein Domain

IPR033328 | BTG2

Type:

Family

Description:

BTG2 is a member of the BTG/Tob family. It plays an important role in cellular differentiation and cancer. It is a direct transcriptional target of p53 and has been shown to be a major effector of suppression of Ras-induced transformation by p53 []. BTG2 has been shown to function as a transcription cofactor []. BTG2 is also found to interact directly with the first RRM domain of the poly(A)-binding protein PABPC1 and promoted mRNA poly(A) tail shortening []. In mice, its overexpression during neurogenesis led to microcephaly, while its deletion triggered impaired neuronal differentiation [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation [].

•

HT Experiment

GSE57998 | Ataxin-2 modulates mRNA levels of proteins in ribosomal large and small subunit and in translation initiation complex


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

Publication

19141475 | J:200392

First Author:	Yoh SM
Year:	2008
Journal:	Genes Dev
Title:	The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.
Volume:	22
Issue:	24
Pages:	3422-34

•

Publication

17785442 | J:129072

First Author:	Ezzeddine N
Year:	2007
Journal:	Mol Cell Biol
Title:	Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.
Volume:	27
Issue:	22
Pages:	7791-801

•

Publication

10617598 | -

First Author:	Prévôt D
Year:	2000
Journal:	J Biol Chem
Title:	The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation.
Volume:	275
Issue:	1
Pages:	147-53

•

Publication

25721894 | J:261271

First Author:	Fittschen M
Year:	2015
Journal:	Neurogenetics
Title:	Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.
Volume:	16
Issue:	3
Pages:	181-92

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Protein

Q04211

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	false

•

Protein

Q8C2A8

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	false

•

Protein

Q3TF68

Organism:	Mus musculus/domesticus
Length:	158
Fragment?:	false

•

Publication

19746446 | -

First Author:	Winkler GS
Year:	2010
Journal:	J Cell Physiol
Title:	The mammalian anti-proliferative BTG/Tob protein family.
Volume:	222
Issue:	1
Pages:	66-72

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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