Type |
Details |
Score |
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
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Publication |
First Author: |
Rosario R |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
Dazl determines primordial follicle formation through the translational regulation of Tex14. |
Volume: |
33 |
Issue: |
12 |
Pages: |
14221-14233 |
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•
•
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Publication |
First Author: |
Zhang C |
Year: |
2016 |
Journal: |
FASEB J |
Title: |
Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility. |
Volume: |
30 |
Issue: |
10 |
Pages: |
3424-3440 |
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•
•
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•
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Publication |
First Author: |
Tung JY |
Year: |
2006 |
Journal: |
Dev Genes Evol |
Title: |
Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ. |
Volume: |
216 |
Issue: |
3 |
Pages: |
158-68 |
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•
•
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•
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Publication |
First Author: |
Rengaraj D |
Year: |
2010 |
Journal: |
Theriogenology |
Title: |
Conserved expression pattern of chicken DAZL in primordial germ cells and germ-line cells. |
Volume: |
74 |
Issue: |
5 |
Pages: |
765-76 |
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•
•
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•
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Publication |
First Author: |
Venables JP |
Year: |
2001 |
Journal: |
Nucleic Acids Res |
Title: |
The RNA-binding specificity of the mouse Dazl protein. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2479-83 |
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•
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•
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Publication |
First Author: |
Zeng M |
Year: |
2009 |
Journal: |
Mol Biol Rep |
Title: |
DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression. |
Volume: |
36 |
Issue: |
8 |
Pages: |
2399-403 |
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•
•
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•
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Publication |
First Author: |
Shah C |
Year: |
2010 |
Journal: |
PLoS Genet |
Title: |
Widespread presence of human BOULE homologs among animals and conservation of their ancient reproductive function. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e1001022 |
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•
•
•
•
•
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Publication |
First Author: |
Vangompel MJ |
Year: |
2011 |
Journal: |
Spermatogenesis |
Title: |
The roles of the DAZ family in spermatogenesis: More than just translation? |
Volume: |
1 |
Issue: |
1 |
Pages: |
36-46 |
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•
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•
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Protein Domain |
Type: |
Family |
Description: |
In humans, the DAZ gene family consists of DAZ on the Y chromosome and 2 autosomal members: DAZL (DAZ-like) and BOULE. Although the DAZ gene evolved relatively recently and is present only in primates, DAZL and BOULE are much more ancient and conserved. BOULE homologues are present throughout eumetazoan animals, from sea anemones to mammals, and DAZL homologues are present in bony fish, amphibians, reptiles, birds, and mammals []. BOULE is highly expressed in the testis, whereas DAZL appears to be highly expressed in both the testis and the ovary [].DAZ family members are RNA binding proteins that play important roles in animal germ cell development [, ]. They function as adaptors for target mRNA transport and activators of their translation. Deletion of the DAZ gene is the most common cause of infertility in humans []. |
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Allele |
Name: |
transgene insertion 10, Renee Reijo Pera |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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Allele |
Name: |
transgene insertion 4, David L Garbers |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
160
|
Fragment?: |
false |
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•
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Strain |
Attribute String: |
transgenic, coisogenic |
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•
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Publication |
First Author: |
Nicholas CR |
Year: |
2009 |
Journal: |
Genesis |
Title: |
Characterization of a Dazl-GFP germ cell-specific reporter. |
Volume: |
47 |
Issue: |
2 |
Pages: |
74-84 |
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•
•
•
•
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Publication |
First Author: |
Ramos-Ibeas P |
Year: |
2013 |
Journal: |
Reproduction |
Title: |
Most regions of mouse epididymis are able to phagocytose immature germ cells. |
Volume: |
146 |
Issue: |
5 |
Pages: |
481-9 |
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•
•
•
•
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Strain |
Attribute String: |
transgenic, mutant stock |
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•
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•
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Publication |
First Author: |
Xu EY |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. |
Volume: |
98 |
Issue: |
13 |
Pages: |
7414-9 |
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•
•
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•
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Publication |
First Author: |
Karashima T |
Year: |
2000 |
Journal: |
Development |
Title: |
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis. |
Volume: |
127 |
Issue: |
5 |
Pages: |
1069-79 |
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•
•
•
•
•
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Publication |
First Author: |
Sekizaki H |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Tracing of Xenopus tropicalis germ plasm and presumptive primordial germ cells with the Xenopus tropicalis DAZ-like gene. |
Volume: |
229 |
Issue: |
2 |
Pages: |
367-72 |
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•
•
•
•
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Publication |
First Author: |
Xu H |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka. |
Volume: |
4 |
Issue: |
6 |
Pages: |
e6097 |
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•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
DAZ (Deleted in Azoospermia) proteins are found almost exclusively in germ cells in distant animal species. Deletion or mutations of their encoding genes usually impair either oogenesis or spermatogenesis or both. The family includes three members, Boule (or Boll), Dazl (or Dazla) and DAZ, encoding RNA binding proteins. Boule is the ancestral gene that is conserved from flies to humans, whereas, Dazl arose in the early vertebrate lineage and Daz arrived on Y chromosome during primate evolution. Basically, DAZ family proteins have been proposed to function as adaptors for target mRNA transport and activators of their translation. These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and one (Boule and Dazl) or multiple copies (Daz) of the DAZ domain, a 24 amino acids motif rich in Asn, Tyr, and Gln residues. The function of the DAZ domain is not known, but may be involved in protein-protein interactions [, , , , ]. The entry represents the DAZ domain. |
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•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the RNA recognition motif (RRM) domain of Deleted in AZoospermia (DAZ) homologues from invertebrates. Invertebrates contain a single DAZ homologue, known as BOULE in Drosophila, while vertebrates, other than catarrhine primates, possess both BOULE and DAZL (DAZ-like) genes. The catarrhine primates possess BOULE, DAZL, and DAZ genes []. The family members encode closely related RNA-binding proteins that are required for fertility in numerous organisms. These proteins contain an RNA recognition motif (RRM) and a varying number of copies of a DAZ motif, believed to mediate protein-protein interactions. DAZL and BOULE contain a single copy of the DAZ motif, while DAZ proteins can contain 8-24 copies of this repeat []. DAZ proteins are involved in gametogenesis []. |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
87
|
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
293
|
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
282
|
Fragment?: |
true |
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•
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Publication |
First Author: |
Bin L |
Year: |
2007 |
Journal: |
Mol Reprod Dev |
Title: |
Identification and characterization of TSAP, a novel gene specifically expressed in testis during spermatogenesis. |
Volume: |
74 |
Issue: |
9 |
Pages: |
1141-8 |
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•
•
•
•
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Publication |
First Author: |
Gura MA |
Year: |
2020 |
Journal: |
PLoS Genet |
Title: |
Dynamic and regulated TAF gene expression during mouse embryonic germ cell development. |
Volume: |
16 |
Issue: |
1 |
Pages: |
e1008515 |
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•
•
•
•
|
HT Experiment |
Series Id: |
E-GEOD-11631 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
GEO |
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•
•
•
•
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Publication |
First Author: |
Sha QQ |
Year: |
2017 |
Journal: |
Development |
Title: |
A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes. |
Volume: |
144 |
Issue: |
3 |
Pages: |
452-463 |
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•
•
•
•
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Publication |
First Author: |
Moore FL |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. |
Volume: |
100 |
Issue: |
2 |
Pages: |
538-43 |
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•
•
•
•
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Publication |
First Author: |
Garcia TX |
Year: |
2017 |
Journal: |
Stem Cells Dev |
Title: |
The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells. |
Volume: |
26 |
Issue: |
8 |
Pages: |
585-598 |
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