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Search results 101 to 139 out of 139 for Gamt

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Type Details Score
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
17336114 | -
First Author: Almeida LS
Year: 2007
Journal: Mol Genet Metab
Title: A prevalent pathogenic GAMT mutation (c.59G>C) in Portugal.
Volume: 91
Issue: 1
Pages: 1-6
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DO Term
DOID:0050799 | guanidinoacetate methyltransferase deficiency
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Allele
Gamt<em1Smoc> | MGI:7289818
Name: guanidinoacetate methyltransferase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475328 | C57BL/6-Gamt<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
15245487 | -
First Author: Tachikawa M
Year: 2004
Journal: Eur J Neurosci
Title: Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.
Volume: 20
Issue: 1
Pages: 144-60
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Allele
Gamt<tm1Isb> | MGI:3044282
Name: guanidinoacetate methyltransferase; targeted mutation 1, Dirk Isbrandt
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Gamt/Gamt
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Publication
12079381 | -
First Author: Komoto J
Year: 2002
Journal: J Mol Biol
Title: Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.
Volume: 320
Issue: 2
Pages: 223-35
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Publication
7808840 | -
First Author: Stöckler S
Year: 1994
Journal: Pediatr Res
Title: Creatine deficiency in the brain: a new, treatable inborn error of metabolism.
Volume: 36
Issue: 3
Pages: 409-13
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Protein Domain
IPR016550 | GuanidinoAc_N-MeTrfase
Type: Family
Description: Guanidinoacetate methyltransferase (GAMT; ) catalyses the last step of creatine biosynthesis. In humans, GAMT is believed to be the major enzyme involved in the metabolic conversion of S-adenosylmethionine (SAM) to S-adenosylhomocycteine (SAH). GAMT is found in abundance in the liver of all vertebrates. The crystal structure of a truncated version of GAMT shows that it exists as a dimer [], and the structure can be viewed as a ternary complex between protein arginine methyltransferase (one subunit) complexed with a protein substrate (the partner subunit) and the product SAH []. Deficiency of GAMT in the liver causes a hereditary disease with extra pyramidal motor disorder and extremely low concentrations of creatine in the brain, serum and urine [].
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Protein Domain
IPR026480 | RMT2_dom
Type: Domain
Description: This domain is found in arginine N-methyltransferase 2, a delta-N-monomethylarginine transferase which monomethylates 'Arg-67' of ribosomal protein L12 []. The domain is also found in guanidinoacetate N-methyltransferase (GAMT), defects in which cause GAMT deficiency, an autosomal recessive disorder [].
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Allele
Gamt<m1Btlr> | MGI:6268363
Name: guanidinoacetate methyltransferase; mutaiton 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268364 | C57BL/6J-Gamt<m1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Gamt/Gamt
Background: C57BL/6J-Gamt
Zygosity: hm
Has Mutant Allele: true
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Protein
O35969
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Publication
11856739 | -
First Author: Chern MK
Year: 2002
Journal: J Biol Chem
Title: Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase 2.
Volume: 277
Issue: 18
Pages: 15345-53
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Publication
8547310 | J:30548
First Author: Isbrandt D
Year: 1995
Journal: Biochim Biophys Acta
Title: Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA.
Volume: 1264
Issue: 3
Pages: 265-7
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Publication
25206338 | J:291927
 
First Author: Russell AP
Year: 2014
Journal: Front Physiol
Title: Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.
Volume: 5
Pages: 314
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Publication
34483959 | J:316750
 
First Author: Hannemann J
Year: 2021
Journal: Front Physiol
Title: Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia.
Volume: 12
Pages: 703069
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Publication
36732069 | J:346236
First Author: Rosko LM
Year: 2023
Journal: J Neurosci
Title: Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination.
Volume: 43
Issue: 7
Pages: 1143-1153
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