|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 401 to 500 out of 681 for Kcnq1

0.052s
Type Details Score
Publication
First Author: Terrenoire C
Year: 2009
Journal: J Biol Chem
Title: The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.
Volume: 284
Issue: 14
Pages: 9140-6
Publication
First Author: Dao D
Year: 1999
Journal: Hum Mol Genet
Title: Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting.
Volume: 8
Issue: 7
Pages: 1337-52
Publication
First Author: Sampson KJ
Year: 2008
Journal: J Physiol
Title: Adrenergic regulation of a key cardiac potassium channel can contribute to atrial fibrillation: evidence from an I Ks transgenic mouse.
Volume: 586
Issue: 2
Pages: 627-37
Publication
First Author: Paulsen M
Year: 2000
Journal: Hum Mol Genet
Title: Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.
Volume: 9
Issue: 12
Pages: 1829-41
Publication
First Author: Miwa T
Year: 2020
Journal: Mol Brain
Title: Tsukushi is essential for the development of the inner ear.
Volume: 13
Issue: 1
Pages: 29
Publication
First Author: Mai W
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life.
Volume: 101
Issue: 28
Pages: 10332-7
Publication
First Author: Nguyên-Trân VT
Year: 2000
Journal: Cell
Title: A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
Volume: 102
Issue: 5
Pages: 671-82
Publication
First Author: Wang J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.
Volume: 107
Issue: 21
Pages: 9753-8
Publication
First Author: Gould TD
Year: 1998
Journal: Hum Mol Genet
Title: Imprinting of mouse Kvlqt1 is developmentally regulated.
Volume: 7
Issue: 3
Pages: 483-7
Publication
First Author: Labialle S
Year: 2008
Journal: Hum Mol Genet
Title: Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes.
Volume: 17
Issue: 1
Pages: 15-26
Publication
First Author: Udagawa T
Year: 2024
Journal: Sci Rep
Title: Loss of Pax3 causes reduction of melanocytes in the developing mouse cochlea.
Volume: 14
Issue: 1
Pages: 2210
Publication  
First Author: Renauld JM
Year: 2022
Journal: Front Cell Dev Biol
Title: Intermediate Cells of Dual Embryonic Origin Follow a Basal to Apical Gradient of Ingression Into the Lateral Wall of the Cochlea.
Volume: 10
Pages: 867153
Publication
First Author: Chotalia M
Year: 2009
Journal: Genes Dev
Title: Transcription is required for establishment of germline methylation marks at imprinted genes.
Volume: 23
Issue: 1
Pages: 105-17
Publication
First Author: Caspary T
Year: 1998
Journal: Mol Cell Biol
Title: Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
Volume: 18
Issue: 6
Pages: 3466-74
Publication
First Author: Day CD
Year: 1999
Journal: Mamm Genome
Title: The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing.
Volume: 10
Issue: 2
Pages: 182-5
Publication
First Author: Ainscough JF
Year: 1998
Journal: Genet Res
Title: Mechanism of imprinting on mouse distal chromosome 7.
Volume: 72
Issue: 3
Pages: 237-45
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Kato R
Year: 1999
Journal: DNA Res
Title: Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
Volume: 6
Issue: 6
Pages: 401-5
Publication
First Author: Shibata S
Year: 2016
Journal: J Neurosci
Title: Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing.
Volume: 36
Issue: 31
Pages: 8200-9
Publication
First Author: Chen T
Year: 2021
Journal: Dev Cell
Title: Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
Volume: 56
Issue: 10
Pages: 1526-1540.e7
Publication
First Author: Rose KP
Year: 2023
Journal: iScience
Title: Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset.
Volume: 26
Issue: 10
Pages: 107769
Publication
First Author: Buniello A
Year: 2013
Journal: PLoS One
Title: Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.
Volume: 8
Issue: 2
Pages: e56274
Publication
First Author: Shawer H
Year: 2020
Journal: PLoS One
Title: A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure.
Volume: 15
Issue: 6
Pages: e0233007
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication    
First Author: Fan D
Year: 2019
Journal: Elife
Title: Taste bud formation depends on taste nerves.
Volume: 8
Publication
First Author: Trowe MO
Year: 2011
Journal: Dev Biol
Title: Impaired stria vascularis integrity upon loss of E-cadherin in basal cells.
Volume: 359
Issue: 1
Pages: 95-107
Publication
First Author: Trowe MO
Year: 2008
Journal: Development
Title: Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes.
Volume: 135
Issue: 9
Pages: 1725-34
Publication
First Author: Nishiguchi Y
Year: 2016
Journal: Dev Biol
Title: Bcl11b/Ctip2 is required for development of lingual papillae in mice.
Volume: 416
Issue: 1
Pages: 98-110
Publication  
First Author: Ohmoto M
Year: 2023
Journal: eNeuro
Title: A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.
Volume: 10
Issue: 4
Publication  
First Author: Jiang W
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: ZFP57 dictates allelic expression switch of target imprinted genes.
Volume: 118
Issue: 5
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: JAX Neuroscience Mutagenesis Facility
Year: 2004
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from JAX NMF ENU Mutagenesis Program
Publication
First Author: Peters J
Year: 2004
Journal: Brief Funct Genomic Proteomic
Title: Identification and characterisation of imprinted genes in the mouse.
Volume: 2
Issue: 4
Pages: 320-33
Publication
First Author: Caputo L
Year: 2015
Journal: Cell Stem Cell
Title: The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Volume: 17
Issue: 3
Pages: 287-99
Publication
First Author: Szeto IYY
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms.
Volume: 119
Issue: 46
Pages: e2122121119
Publication      
First Author: Tian C
Year: 2019
Journal: Dev Biol
Title: TBX1 is required for normal stria vascularis and semicircular canal development.
Publication
First Author: Son EJ
Year: 2012
Journal: PLoS One
Title: Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.
Volume: 7
Issue: 7
Pages: e40735
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gao R
Year: 2019
Journal: Cell Res
Title: Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.
Volume: 29
Issue: 6
Pages: 486-501
Publication
First Author: Ross JA
Year: 2023
Journal: Cardiovasc Res
Title: Lem2 is essential for cardiac development by maintaining nuclear integrity.
Volume: 119
Issue: 11
Pages: 2074-2088
Publication
First Author: Kim GE
Year: 2015
Journal: Cardiovasc Res
Title: LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.
Volume: 108
Issue: 1
Pages: 197-208
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Rohacek AM
Year: 2017
Journal: Dev Cell
Title: ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.
Volume: 43
Issue: 3
Pages: 318-331.e5
Publication
First Author: Xie Z
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ZBTB20 is essential for cochlear maturation and hearing in mice.
Volume: 120
Issue: 24
Pages: e2220867120
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Sakamoto T
Year: 2020
Journal: Circ Res
Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
Volume: 126
Issue: 12
Pages: 1685-1702
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
Publication        
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication
First Author: Teng S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Novel gene hKCNE4 slows the activation of the KCNQ1 channel.
Volume: 303
Issue: 3
Pages: 808-13
Publication
First Author: Mohammad F
Year: 2012
Journal: Development
Title: Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing.
Volume: 139
Issue: 15
Pages: 2792-803
Publication
First Author: Sanguinetti MC
Year: 1996
Journal: Nature
Title: Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Volume: 384
Issue: 6604
Pages: 80-3
Publication
First Author: Neyroud N
Year: 1997
Journal: Nat Genet
Title: A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome.
Volume: 15
Issue: 2
Pages: 186-9
Protein Domain
Type: Family
Description: Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.KCNQ channels (also known as KQT-like channels) differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain. Consequently, they rely on interaction with accessory subunits, or form heterotetramers with other members of the family []. Currently, 5 members of the KCNQ family are known. These have been found to be widely distributed within the body, having been shown to be expressed in the heart, brain, pancreas, lung, placenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently, mutations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness []and benign familial neonatal epilepsy [].KCNQ1 was the first member of the KCNQ channel family to be isolated, and has been found to be the most common cause of the disease `long QT syndrome' a cardiac arhythmia resulting in a prolonged QT interval. In exceptional cases, this can lead to sudden death, triggered by extreme stress [, ]. KCNQ1 is expressed in the stria vascularis of the inner ear, and may be the cause of hereditary deafness [].
Publication
First Author: Roepke TK
Year: 2011
Journal: FASEB J
Title: Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo.
Volume: 25
Issue: 2
Pages: 727-36
Publication
First Author: Kanduri C
Year: 2002
Journal: J Biol Chem
Title: A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.
Volume: 277
Issue: 20
Pages: 18106-10
Publication
First Author: Jones MJ
Year: 2011
Journal: Mol Cell Biol
Title: An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
Volume: 31
Issue: 14
Pages: 2827-37
Publication
First Author: Yu XH
Year: 2020
Journal: Cell Death Dis
Title: LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis.
Volume: 11
Issue: 12
Pages: 1043
Allele
Name: transgene insertion H05, Denis Escande
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion H02, Denis Escande
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
Allele    
Name: KCNQ1 overlapping transcript 1; wild type
ncRNA Gene
Type: ncRNA_gene
Organism: Mus caroli
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
lncRNA Gene
Type: lncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: mouse, laboratory
ncRNA Gene
Type: ncRNA_gene
Organism: Mus pahari
ncRNA Gene
Type: ncRNA_gene
Organism: Mus spretus