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Search results 301 to 387 out of 387 for Sfn

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Type Details Score
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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GXD Expression
GXD Expression
   
Probe: MGI:6434791
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:6434851
Age: embryonic day 18.5
Note: Expression was undetectable.
Specimen Label: 2j Sfn Er/+
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6434791
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752826
Stage: TS26
Assay Id: MGI:6434851
Age: embryonic day 18.5
Note: Expression was undetectable.
Specimen Label: 2j Sfn Er/Er
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3033405
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Widespread
Stage: TS26
Assay Id: MGI:6434868
Age: embryonic day 18.5
Specimen Label: 2k Sfn Er/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:3033405
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Widespread
Stage: TS26
Assay Id: MGI:6434868
Age: embryonic day 18.5
Specimen Label: 2k Sfn Er/Er
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6434794
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Widespread
Stage: TS26
Assay Id: MGI:6434873
Age: embryonic day 18.5
Specimen Label: 2l Sfn Er/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6434794
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Widespread
Stage: TS26
Assay Id: MGI:6434873
Age: embryonic day 18.5
Specimen Label: 2l Sfn Er/Er
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6434797
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6434876
Age: embryonic day 18.5
Specimen Label: 2m Sfn Er/+
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6434797
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6434876
Age: embryonic day 18.5
Note: Altered expression in thickened epidermis.
Specimen Label: 2m Sfn Er/Er
Detected: true
Specimen Num: 6
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Allele
Sfn<Er> | MGI:1861121
 
Name: stratifin; repeated epilation
Allele Type: Radiation induced
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Strain
MGI:2161700 | B6CBACa A<w-J>/A-Sfn<Er>/J
Attribute String: mutant strain, spontaneous mutation
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Strain
MGI:5650795 | (DBA/2 x STOCK Sfn<Er>/+)F1
Attribute String: F1 hybrid, mutant stock
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Strain
MGI:5654256 | B6CBA-Sfn<Er>/+
Attribute String: mutant stock, radiation induced mutation
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Strain
MGI:5654257 | (CAST/Ei x B6CBA-Sfn<Er>/+)F1
Attribute String: F1 hybrid, mutant stock, radiation induced mutation
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Strain
MGI:5654255 | (B6CBA-Sfn<Er>/+ x SPRET/Ei)F1
Attribute String: F1 hybrid, mutant stock, radiation induced mutation
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: B6CBACa A/A-Sfn/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn<+>
Background: B6CBACa A/A-Sfn/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: involves: C57BL/6By
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn<+>
Background: involves: FVB/NJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: involves: FVB/NJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sfn/Sfn
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Irf6/Irf6<+> Sfn/Sfn<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Irf6/Irf6<+> Sfn/Sfn
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kdf1/Kdf1<+> Sfn/Sfn<+>
Background: involves: C3HeB/FeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chuk/Chuk<+> Sfn/Sfn
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1888981 | Rexo2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10851236 | J:63995
First Author: Nguyen LH
Year: 2000
Journal: J Biol Chem
Title: The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers.
Volume: 275
Issue: 34
Pages: 25900-6
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Publication
17029243 | -
First Author: Chin KH
Year: 2006
Journal: Proteins
Title: The crystal structure of XC847 from Xanthomonas campestris: a 3'-5' oligoribonuclease of DnaQ fold family with a novel opposingly shifted helix.
Volume: 65
Issue: 4
Pages: 1036-40
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Protein Domain
IPR022894 | Oligoribonuclease
Type: Family
Description: Oligoribonuclease (Orn) is a DEDDh-type DnaQ-like 3'-5' exoribonuclease that is responsible for degrading small oligoribonucleotides to mononucleotides. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Orn is essential for Escherichia coli survival []. The human homologue, also called Sfn (small fragment nuclease), is able to hydrolyse short single-stranded RNA and DNA oligomers. It plays a role in cellular nucleotide recycling [, ].
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Publication
24952354 | J:213557
First Author: Jo C
Year: 2014
Journal: FEBS Lett
Title: Sulforaphane induces autophagy through ERK activation in neuronal cells.
Volume: 588
Issue: 17
Pages: 3081-8
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Publication
16682444 | -
First Author: Mechold U
Year: 2006
Journal: Nucleic Acids Res
Title: Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells.
Volume: 34
Issue: 8
Pages: 2364-73
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Publication
15857578 | -
First Author: Lodygin D
Year: 2005
Journal: Cell Res
Title: The role of epigenetic inactivation of 14-3-3sigma in human cancer.
Volume: 15
Issue: 4
Pages: 237-46
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Publication
9659898 | -
First Author: Hermeking H
Year: 1997
Journal: Mol Cell
Title: 14-3-3sigma is a p53-regulated inhibitor of G2/M progression.
Volume: 1
Issue: 1
Pages: 3-11
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Publication
21115893 | -
First Author: Kuramitsu Y
Year: 2010
Journal: Anticancer Res
Title: Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells.
Volume: 30
Issue: 11
Pages: 4459-65
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Publication
24030981 | -
First Author: Khongmanee A
Year: 2013
Journal: Proteomics
Title: Proteomic analysis reveals important role of 14-3-3σ in anoikis resistance of cholangiocarcinoma cells.
Volume: 13
Issue: 21
Pages: 3157-66
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Protein Domain
IPR037435 | 14-3-3_sigma
Type: Family
Description: 14-3-3 protein sigma isoform, also known as stratifin or human mammary epithelial marker (HME) 1, has been most directly linked to tumour development [, ]. In humans, it is expressed by the SFN gene, strictly in stratified squamous epithelial cells in response to DNA damage where it is transcriptionally induced in a p53-dependent manner, subsequently causing cell-cycle arrest at the G2/M checkpoint []. Up-regulation and down-regulation of 14-3-3 sigma expression have both been described in tumours. For example, in human breast cancer, 14-3-3 sigma is predominantly down-regulated by CpG methylation, acting as both a tumour suppressor and a prognostic indicator [], while in human scirrhous-type gastric carcinoma (SGC), it is up-regulated and may play an important role in SGC carcinogenesis and progression []. Loss of 14-3-3 sigma expression sensitizes tumour cells to treatment with conventional cytostatic drugs, making this protein an attractive therapeutic target [].
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Publication
24943846 | J:317641
First Author: Guo S
Year: 2014
Journal: Mol Biol Cell
Title: Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity.
Volume: 25
Issue: 16
Pages: 2485-98
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Publication
31555797 | J:283651
First Author: Singh KB
Year: 2019
Journal: Carcinogenesis
Title: Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.
Volume: 40
Issue: 12
Pages: 1545-1556
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Publication
29668854 | J:262595
First Author: Singh KB
Year: 2018
Journal: Carcinogenesis
Title: Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism.
Volume: 39
Issue: 6
Pages: 826-837
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Publication
19223537 | J:146610
First Author: Singh SV
Year: 2009
Journal: Cancer Res
Title: Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Volume: 69
Issue: 5
Pages: 2117-25
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Publication
23153560 | J:193202
First Author: Poulton EJ
Year: 2013
Journal: Toxicol Appl Pharmacol
Title: Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Volume: 266
Issue: 1
Pages: 122-31
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Publication
37857700 | J:346049
First Author: Ye X
Year: 2023
Journal: Commun Biol
Title: Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2.
Volume: 6
Issue: 1
Pages: 1060
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Publication
24691443 | J:212768
First Author: Liu YP
Year: 2014
Journal: J Clin Invest
Title: Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.
Volume: 124
Issue: 5
Pages: 2059-70
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Publication
26923074 | J:234368
First Author: Sasaki M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone.
Volume: 472
Issue: 1
Pages: 250-4
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Publication
26494449 | J:328050
First Author: Sun C
Year: 2016
Journal: J Appl Physiol (1985)
Title: Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.
Volume: 120
Issue: 4
Pages: 377-90
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Publication
27903744 | J:253114
First Author: Gu J
Year: 2017
Journal: Diabetes
Title: Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy.
Volume: 66
Issue: 2
Pages: 529-542
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Publication
36512409 | J:337667
 
First Author: Ievlev V
Year: 2023
Journal: JCI Insight
Title: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
Volume: 8
Issue: 2
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Publication
35304580 | J:335939
First Author: Ordonez AA
Year: 2022
Journal: Commun Biol
Title: Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice.
Volume: 5
Issue: 1
Pages: 242
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Publication
28937835 | J:280325
First Author: Kang K
Year: 2017
Journal: Curr Eye Res
Title: Protective effect of sulforaphane against retinal degeneration in the Pde6rd10 mouse model of retinitis pigmentosa.
Volume: 42
Issue: 12
Pages: 1684-1688
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Publication
29684505 | J:265076
 
First Author: Pu D
Year: 2018
Journal: Neuroscience
Title: Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.
Volume: 381
Pages: 35-45
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Publication
16675473 | J:113352
First Author: Hu R
Year: 2006
Journal: Carcinogenesis
Title: Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.
Volume: 27
Issue: 10
Pages: 2038-46
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Publication
16407454 | J:107343
First Author: Myzak MC
Year: 2006
Journal: FASEB J
Title: Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.
Volume: 20
Issue: 3
Pages: 506-8
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Publication
21303654 | J:171636
First Author: Harada N
Year: 2011
Journal: Arch Biochem Biophys
Title: Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
Volume: 508
Issue: 1
Pages: 101-9
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Publication
29018242 | J:255757
First Author: Oh S
Year: 2017
Journal: Sci Rep
Title: Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles.
Volume: 7
Issue: 1
Pages: 12902
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Publication
16516379 | J:114604
First Author: Hu R
Year: 2006
Journal: Cancer Lett
Title: Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.
Volume: 243
Issue: 2
Pages: 170-92
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Publication
31004475 | J:277120
First Author: Mu Y
Year: 2019
Journal: Biol Reprod
Title: Sulforaphane ameliorates high-fat diet-induced spermatogenic deficiency in mice†.
Volume: 101
Issue: 1
Pages: 223-234
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Publication
18619545 | J:141862
First Author: Rojo AI
Year: 2008
Journal: Mol Cell Neurosci
Title: Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.
Volume: 39
Issue: 1
Pages: 125-32
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Publication
22581777 | J:197765
First Author: Chorley BN
Year: 2012
Journal: Nucleic Acids Res
Title: Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.
Volume: 40
Issue: 15
Pages: 7416-29
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Publication
23583403 | J:201856
First Author: Koo JE
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.
Volume: 434
Issue: 3
Pages: 600-5
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Publication
24948812 | J:212080
First Author: Wang X
Year: 2014
Journal: J Neurosci
Title: Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers.
Volume: 34
Issue: 25
Pages: 8585-93
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Publication
27979663 | J:241794
First Author: Takagi T
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.
Volume: 483
Issue: 1
Pages: 718-724
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Publication
30086367 | J:267046
 
First Author: Gao J
Year: 2018
Journal: Neuroscience
Title: Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway.
Volume: 388
Pages: 357-366
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Publication
26223682 | J:288990
 
First Author: Shiba-Ishii A
Year: 2015
Journal: Mol Cancer
Title: Stratifin accelerates progression of lung adenocarcinoma at an early stage.
Volume: 14
Pages: 142
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Publication
35628208 | J:324986
 
First Author: Zheng J
Year: 2022
Journal: Int J Mol Sci
Title: Tumor Promoting Effects of Sulforaphane on Diethylnitrosamine-Induced Murine Hepatocarcinogenesis.
Volume: 23
Issue: 10
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Publication
35955572 | J:327687
 
First Author: Shimizu S
Year: 2022
Journal: Int J Mol Sci
Title: Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Volume: 23
Issue: 15
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Publication
38007430 | J:343456
First Author: Ma C
Year: 2023
Journal: Cell Death Dis
Title: Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling.
Volume: 14
Issue: 11
Pages: 768
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Publication
23921360 | J:202523
First Author: Vyas AR
Year: 2013
Journal: Cancer Res
Title: Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy.
Volume: 73
Issue: 19
Pages: 5985-95
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Publication
22180572 | J:181508
First Author: Krehl S
Year: 2012
Journal: Carcinogenesis
Title: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Volume: 33
Issue: 3
Pages: 620-8
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Publication
28700700 | J:248037
First Author: McDonnell C
Year: 2017
Journal: PLoS One
Title: The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice.
Volume: 12
Issue: 7
Pages: e0180998
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Publication
17942926 | J:126014
First Author: Shen G
Year: 2007
Journal: Cancer Res
Title: Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.
Volume: 67
Issue: 20
Pages: 9937-44
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Publication
36244590 | J:331564
First Author: Li Q
Year: 2022
Journal: Free Radic Biol Med
Title: Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway.
Volume: 193
Issue: Pt 1
Pages: 292-303
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Publication
34925037 | J:342722
 
First Author: Chidiac C
Year: 2021
Journal: Front Pharmacol
Title: The Human SCN10A(G1662S) Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity.
Volume: 12
Pages: 780132
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Protein
Q9D8S4
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q8BJ91
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
A0A1L1SS70
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q78KL9
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
Q3T9B4
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
A0A1L1SS58
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
Q3TAV0
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Protein
Q3UD20
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: true
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Protein
A0A1L1SQJ5
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Protein
O70456
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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