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Search results 101 to 200 out of 201 for Mocs2

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Hits by Category

Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:6711680
Assay Type: RT-PCR
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712793
Age: postnatal adult
Specimen Label: Kidney +/-
Detected: true
Specimen Num: 8
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711680
Assay Type: RT-PCR
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712793
Age: postnatal adult
Specimen Label: Kidney -/-
Detected: false
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711680
Assay Type: RT-PCR
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6712793
Age: postnatal adult
Specimen Label: Skin +/+
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711680
Assay Type: RT-PCR
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6712793
Age: postnatal adult
Specimen Label: Skin +/-
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711680
Assay Type: RT-PCR
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:6712793
Age: postnatal adult
Specimen Label: Skin -/-
Detected: false
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Brain +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Brain +/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Brain -/-
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Liver +/+
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Liver +/-
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Liver -/-
Detected: false
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Kidney +/+
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Kidney +/-
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712794
Age: postnatal adult
Specimen Label: Kidney -/-
Detected: false
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Brain +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Brain +/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Brain -/-
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Liver +/+
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Liver +/-
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Liver -/-
Detected: false
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Kidney +/+
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Kidney +/-
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6711678
Assay Type: Western blot
Annotation Date: 2021-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6712795
Age: postnatal adult
Specimen Label: Kidney -/-
Detected: false
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Strong
Sex: Male
Emaps: EMAPS:3148228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Note: Expression was detected in undifferentiated spermatogonia.
Specimen Label: S5d
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3a
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1903728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3b
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Weak
Sex: Female
Emaps: EMAPS:2888028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5e
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2840728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5c
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1794828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5c
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1867628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5c
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3a
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3b
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3a
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3b
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3582328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Note: Expression was in longitudinal smooth muscle.
Specimen Label: S5b
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Pattern: Regionally restricted
Stage: TS12
Assay Id: MGI:6712710
Age: embryonic day 8.0
Note: Expression was detected in the headfolds.
Specimen Label: S4
Detected: true
Specimen Num: 3
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•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116912
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:6712710
Age: embryonic day 8.0
Specimen Label: S4
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5a
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616412
Pattern: Not Specified
Stage: TS12
Assay Id: MGI:6712710
Age: embryonic day 8.0
Specimen Label: S4
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1877128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5f
Detected: true
Specimen Num: 9
•
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•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3581728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5b
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Strong
Sex: Female
Emaps: EMAPS:3102528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5e
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1756328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3a
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1756328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: 3b
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3764028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712710
Age: postnatal adult
Specimen Label: S5b
Detected: true
Specimen Num: 5
•
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•
•
•
Publication
11591653 | J:103507
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
16737835 | -
First Author: Hahnewald R
Year: 2006
Journal: Mol Genet Metab
Title: A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase.
Volume: 89
Issue: 3
Pages: 210-3
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Allele
Mocs2<em1Smoc> | MGI:7291130
Name: molybdenum cofactor synthesis 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein
A0A0R4J206
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Strain
MGI:6475808 | C57BL/6-Mocs2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Mocs2<tm1(KOMP)Vlcg> | MGI:4881158
Name: molybdenum cofactor synthesis 2; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Protein
F6ZGI7
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: false
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Genotype
Genotype
Symbol: Mocs2/Mocs2
Background: involves: C57BL/6NTac
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0111163 | molybdenum cofactor deficiency type B
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Publication
10383438 | -
First Author: Unkles SE
Year: 1999
Journal: J Biol Chem
Title: Eukaryotic molybdopterin synthase. Biochemical and molecular studies of Aspergillus nidulans cnxG and cnxH mutants.
Volume: 274
Issue: 27
Pages: 19286-93
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Protein Domain
IPR028888 | MOCS2B_euk
Type: Family
Description: Eukaryotic molybdopterin synthase, like the Escherichia coli MoaD-MoaE counterpart, is a heterotetramer that is composed of two subunits: MOCS2A and MOCS2B. MOCS2B is the catalytic subunit of the molybdopterin synthase complex (MOCS2), a complex that catalyses the conversion of precursor Z into molybdopterin. MOC2SB acts by mediating the incorporation of two sulfur atoms from thiocarboxylated MOCS2A (the small MOCS2 subunit which functions as a sulfur carrier) into precursor Z to generate a dithiolene group [, , , ].Mutations in human MOCS2B gene cause Molybdenum cofactor deficiency type B (MOCOD type B), an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterised by severe neurological damage, neonatal seizures and early childhood death [].
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Protein
Q9Z223
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Publication
10053004 | -
First Author: Reiss J
Year: 1999
Journal: Am J Hum Genet
Title: Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B.
Volume: 64
Issue: 3
Pages: 706-11
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Publication
12754701 | -
First Author: Reiss J
Year: 2003
Journal: Hum Mutat
Title: Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH.
Volume: 21
Issue: 6
Pages: 569-76
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Protein Domain
IPR010505 | Mob_synth_C
Type: Domain
Description: The majority of molybdenum-containing enzymes utilise a molybdenum cofactor (MoCF or Moco) consisting of a Mo atom coordinated via a cis-dithiolene moiety to molybdopterin (MPT). MoCF is ubiquitous in nature, and the pathway for MoCF biosynthesis is conserved in all three domains of life. MoCF-containing enzymes function as oxidoreductases in carbon, nitrogen, and sulphur metabolism [, ]. In Escherichia coli, biosynthesis of MoCF is a three stage process. It begins with the MoaA and MoaC conversion of GTP to the meta-stable pterin intermediate precursor Z. The second stage involves MPT synthase (MoaD and MoaE), which converts precursor Z to MPT; MoeB is involved in the recycling of MPT synthase. The final step in MoCF synthesis is the attachment of mononuclear Mo to MPT, a process that requires MoeA and which is enhanced by MogA in an Mg2 ATP-dependent manner []. MoCF is the active co-factor in eukaryotic and some prokaryotic molybdo-enzymes, but the majorityof bacterial enzymes requiring MoCF, need a modification of MTP for it to be active; MobA is involved in the attachment of a nucleotide monophosphate to MPT resulting in the MGD co-factor, the active co-factor for most prokaryotic molybdo-enzymes. Bacterial two-hybrid studies have revealed the close interactions between MoeA, MogA, and MobA in the synthesis of MoCF []. Moreover the close functional association of MoeA and MogA in the synthesis of MoCF is supported by fact that the known eukaryotic homologues to MoeA and MogA exist as fusion proteins: CNX1 () of Arabidopsis thaliana (Mouse-ear cress), mammalian Gephryin (e.g. ) and Drosophila melanogaster (Fruit fly) Cinnamon () [].This entry represents MoaA (also known as GTP 3',8-cyclase), which belongs to a family of enzymes involved in the synthesis of metallo-cofactors (). Each subunit of the MoaA dimer is comprised of an N-terminal SAM domain () that contains the [4Fe-4S]cluster typical for this family of enzymes, as well as an additional [4Fe-4S]cluster in the C-terminal domain that is unique to MoaA proteins []. The unique Fe site of the C-terminal [4Fe-4S]cluster is thought to be involved in the binding and activation of 5'-GTP.Mutations in the human MoCF biosynthesis proteins MOCS1, MOCS2 or GEPH cause MoCF Deficiency type A (MOCOD), causing the loss of activity of MoCF-containing enzymes, resulting in neurological abnormalities and death [].
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Publication
15317939 | -
First Author: Hänzelmann P
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.
Volume: 101
Issue: 35
Pages: 12870-5
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Protein
Q5RKZ7
Organism: Mus musculus/domesticus
Length: 636  
Fragment?: false
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Publication
12372836 | -
First Author: Magalon A
Year: 2002
Journal: J Biol Chem
Title: In vivo interactions between gene products involved in the final stages of molybdenum cofactor biosynthesis in Escherichia coli.
Volume: 277
Issue: 50
Pages: 48199-204
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Publication
8528286 | -
First Author: Stallmeyer B
Year: 1995
Journal: Plant J
Title: Molybdenum co-factor biosynthesis: the Arabidopsis thaliana cDNA cnx1 encodes a multifunctional two-domain protein homologous to a mammalian neuroprotein, the insect protein Cinnamon and three Escherichia coli proteins.
Volume: 8
Issue: 5
Pages: 751-62
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Publication
17198377 | -
First Author: Nichols JD
Year: 2007
Journal: Biochemistry
Title: Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft.
Volume: 46
Issue: 1
Pages: 78-86
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Publication
12114025 | -
First Author: Hille R
Year: 2002
Journal: Trends Biochem Sci
Title: Molybdenum and tungsten in biology.
Volume: 27
Issue: 7
Pages: 360-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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