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Search results 201 to 300 out of 307 for Mta1

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Metastasis-associated protein MTA1
Type: chain
End: 715
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Protein
Q2KHS8
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein Domain
IPR031724 | EELM2
Type: Domain
Description: EELM2, the extended EGL-27 and MTA1 homology domain, occurs in proteins from apicomplexan parasites. Part of the EELM2 domain is homologous to the ELM2 domain, but is 'extended' in that its boundaries (the region of conservation) are longer than in the ELM2 domain. Currently (as of 2012), little is known about the function of this domain. However, some proteins that contain an EELM2 domain also contain a PHD finger domain, which is thought to be involved in chromatin remodelling. This suggests an associated role for the EELM2 domain [].
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Publication
31783401 | J:296620
First Author: Nan P
Year: 2020
Journal: Carcinogenesis
Title: MTA1 promotes tumorigenesis and development of esophageal squamous cell carcinoma via activating the MEK/ERK/p90RSK signaling pathway.
Volume: 41
Issue: 9
Pages: 1263-1272
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Protein
Q8K4B0
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
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Publication
18264140 | J:138484
First Author: Yoo YG
Year: 2008
Journal: Oncogene
Title: Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.
Volume: 27
Issue: 24
Pages: 3405-13
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Publication
31152708 | J:282145
First Author: Song Q
Year: 2019
Journal: Exp Cell Res
Title: MTA1 promotes the invasion and migration of oral squamous carcinoma by inducing epithelial-mesenchymal transition via the hedgehog signaling pathway.
Volume: 382
Issue: 1
Pages: 111450
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Protein
M1VQI9
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
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Protein
M1VB37
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
E9PX23
Organism: Mus musculus/domesticus
Length: 703  
Fragment?: false
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Protein
M1VHG3
Organism: Mus musculus/domesticus
Length: 686  
Fragment?: false
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Protein
M1VMF6
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: false
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Protein
F8WHY8
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
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Protein
M1VHG6
Organism: Mus musculus/domesticus
Length: 702  
Fragment?: false
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Protein
M1VHG1
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
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Protein
M1V1V1
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
M1VQI8
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Publication
23181666 | -
First Author: Oehring SC
Year: 2012
Journal: Genome Biol
Title: Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum.
Volume: 13
Issue: 11
Pages: R108
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Publication
28314777 | -
First Author: Pakala SB
Year: 2017
Journal: J Biol Chem
Title: Regulation of NF-κB circuitry by a component of the nucleosome remodeling and deacetylase complex controls inflammatory response homeostasis.
Volume: 292
Issue: 11
Pages: 4764
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Interaction Experiment
Simpson A (2001)
Description: Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.
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Interaction Experiment
Ghanta KS (2011)
Description: MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response.
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Publication
12370427 | -
First Author: Zhou J
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expression.
Volume: 99
Issue: 21
Pages: 13693-8
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Publication
15077195 | -
First Author: Mishra SK
Year: 2004
Journal: Oncogene
Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
Volume: 23
Issue: 25
Pages: 4422-9
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Publication
21156794 | -
First Author: Ghanta KS
Year: 2011
Journal: J Biol Chem
Title: MTA1 coregulation of transglutaminase 2 expression and function during inflammatory response.
Volume: 286
Issue: 9
Pages: 7132-8
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Protein
D3YUX3
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
A0A0A6YX54
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
A0A0A6YXI3
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Publication
10226007 | -
First Author: Solari F
Year: 1999
Journal: Development
Title: The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning.
Volume: 126
Issue: 11
Pages: 2483-94
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Protein Domain
IPR000949 | ELM2_dom
Type: Domain
Description: The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex []. The domain is usually found to the N terminus of a myb-like DNA binding domain and a GATA binding domain. ELM2, in some instances, is also found associated with the ARID DNA binding domain . This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.
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Publication
16445996 | -
First Author: Yaguchi M
Year: 2005
Journal: Biochim Biophys Acta
Title: Identification and characterization of the variants of metastasis-associated protein 1 generated following alternative splicing.
Volume: 1732
Issue: 1-3
Pages: 8-14
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Publication
27098840 | -
 
First Author: Millard CJ
Year: 2016
Journal: Elife
Title: The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Volume: 5
Pages: e13941
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Protein Domain
IPR035170 | MTA1_R1
Type: Domain
Description: The R1 domain is found in the MTA1 protein and its homologues. The domain is composed of 4 alpha helices. It has been shown to bind to the RBBP4 protein []. The MTA proteins contain a second partial copy of this domain called R2. The R2 domain is matched by this model for some proteins.
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Publication
19116762 | -
First Author: Toh Y
Year: 2009
Journal: Clin Exp Metastasis
Title: The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications.
Volume: 26
Issue: 3
Pages: 215-27
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Publication
10444591 | J:56739
First Author: Zhang Y
Year: 1999
Journal: Genes Dev
Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Volume: 13
Issue: 15
Pages: 1924-35
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Protein
E9Q500
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
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Protein
E9Q674
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
E9Q3D9
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
E9Q269
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Protein Domain
IPR040138 | MIER/MTA
Type: Family
Description: MTA (metastasis-associated) proteins, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of MTA proteins have been linked to human cancers [].Mesoderm induction early response proteins (MIER1-3) are ELM2-SANT domain-containing proteins. MIER1 functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity[]. The function of MIER2 and MIER3 is not clear [].
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Protein Domain
IPR037964 | MTA2
Type: Family
Description: Metastasis-associated protein MTA2 is a component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD) []. It is a member of the MTA family.MTA (metastasis-associated) family members, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of the MTA family members have been linked to human cancers [].
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Publication
16269335 | J:178278
First Author: Chen WY
Year: 2005
Journal: Cell
Title: Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Volume: 123
Issue: 3
Pages: 437-48
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Publication
20154726 | J:168266
First Author: Zhang W
Year: 2010
Journal: Oncogene
Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume: 29
Issue: 17
Pages: 2467-76
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Publication
19525223 | -
First Author: Van Rechem C
Year: 2009
Journal: J Biol Chem
Title: Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).
Volume: 284
Issue: 31
Pages: 20927-35
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Publication
15231840 | -
First Author: Pinte S
Year: 2004
Journal: J Biol Chem
Title: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.
Volume: 279
Issue: 37
Pages: 38313-24
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Publication
20547755 | -
First Author: Van Rechem C
Year: 2010
Journal: Mol Cell Biol
Title: Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Volume: 30
Issue: 16
Pages: 4045-59
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Protein Domain
IPR028424 | HIC1
Type: Family
Description: Hypermethylated in cancer 1 (HIC1) is a transcriptional repressor that modulates P53-dependent and E2F1-dependent cell growth control and is epigenetically inactivated in various human cancers []. It recognises and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' []. It is a direct transcriptional repressor of ephrin-A1 and CXCR7, which are implicated in the pathogenesis of different cancers [, ]. HIC1 is also involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses []. HIC1 interacts with several different corepressors such as CTBP1, CTBP2 and MTA1 (a subunit of the NuRD complex) [].
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Publication
28231399 | J:241644
First Author: Dhar S
Year: 2017
Journal: FEBS Lett
Title: MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness.
Volume: 591
Issue: 6
Pages: 924-933
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Publication
29880719 | J:265874
First Author: Korfanty J
Year: 2018
Journal: Reproduction
Title: SPEN protein expression and interactions with chromatin in mouse testicular cells.
Volume: 156
Issue: 3
Pages: 195-206
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Protein
A0A338P704
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
D6RET2
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
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Protein
A0A338P6F0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Publication
17671172 | J:123918
First Author: Bagheri-Yarmand R
Year: 2007
Journal: Cancer Res
Title: Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas.
Volume: 67
Issue: 15
Pages: 7062-7
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Publication
18454139 | J:145663
First Author: Liang J
Year: 2008
Journal: Nat Cell Biol
Title: Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Volume: 10
Issue: 6
Pages: 731-9
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Publication
22253283 | J:181163
First Author: Li DQ
Year: 2012
Journal: Cancer Res
Title: Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer.
Volume: 72
Issue: 2
Pages: 387-94
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Protein
H3BIY7
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Publication
23397229 | J:316825
First Author: Cuello-Carrión FD
Year: 2013
Journal: Cell Stress Chaperones
Title: In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1-/- alters PTEN and NHERF1 but not β-catenin expression.
Volume: 18
Issue: 5
Pages: 559-67
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Publication
15226262 | J:90989
First Author: Bagheri-Yarmand R
Year: 2004
Journal: Development
Title: Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis.
Volume: 131
Issue: 14
Pages: 3469-79
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Protein
Q8C929
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Publication
28046085 | -
First Author: Derwish R
Year: 2017
Journal: PLoS One
Title: Differential HDAC1 and 2 Recruitment by Members of the MIER Family.
Volume: 12
Issue: 1
Pages: e0169338
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Protein
Q9R190
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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Protein
Q3TZP3
Organism: Mus musculus/domesticus
Length: 668  
Fragment?: false
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Protein
Q3UDZ8
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: true
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Protein
Q924K8
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q3U3A7
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Protein
Q3TY62
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
E9Q794
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q3UKM9
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
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Protein
A4FTZ3
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q6ZPV1
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: true
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Protein
Q3UII8
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Publication
12482978 | -
First Author: Ding Z
Year: 2003
Journal: Mol Cell Biol
Title: Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Volume: 23
Issue: 1
Pages: 250-8
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Protein
Q3U3N0
Organism: Mus musculus/domesticus
Length: 541  
Fragment?: false
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Protein
Q5UAK0
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
Q3UHF3
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q32P49
Organism: Mus musculus/domesticus
Length: 511  
Fragment?: false
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Protein
B9EHL0
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
H3BLE1
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: true
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Protein
F7BFR0
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: true
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Protein
Q6KDN9
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
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Publication
16533771 | J:110213
First Author: Zhang H
Year: 2006
Journal: Clin Cancer Res
Title: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer.
Volume: 12
Issue: 5
Pages: 1479-86
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Protein
Q8CFE3
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
Q8C796
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
Q6PGA0
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
B2RSN6
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
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Protein
A0A0R4J1I0
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
A0A0A6YWY4
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
A0A0A6YXM5
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
A0A140T8R7
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Protein
B7ZND6
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
A0A0A6YWP7
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
Q8BUZ9
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: true
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Protein
Q3U224
Organism: Mus musculus/domesticus
Length: 1011  
Fragment?: true
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Protein
Q9Z1M6
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
Q80TZ9
Organism: Mus musculus/domesticus
Length: 1558  
Fragment?: false
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Protein
A2A7T3
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
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Protein
A0A1Y7VP67
Organism: Mus musculus/domesticus
Length: 1071  
Fragment?: true
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Protein
E9Q2I4
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: false
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Protein
Q8BXJ2
Organism: Mus musculus/domesticus
Length: 1205  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom