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Search results 1 to 100 out of 271 for Traf1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: TNF receptor-associated factor 1 (TRAF1) plays a role in the regulation of cell survival and apoptosis []. TRAF1 is unique among TRAF proteins in that it lacks a RING domain found in the N-terminal regions of other TRAFs []. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14 [, ].TRAF1 is unique among the TRAFs in that it lacks a RING domain, which is critical for the activation of nuclear factor-kappaB and Jun NH2-terminal kinase. Studies on TRAF1-deficient mice suggest that TRAF1 has a negative regulatory role in TNFR-mediated signaling events []. TRAF1 contains one zinc finger and one TRAF domain.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kato T Jr
Year: 2008
Journal: Genes Cells
Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.
Volume: 13
Issue: 5
Pages: 509-20
Publication  
First Author: Lee SY
Year: 2007
Journal: Adv Exp Med Biol
Title: TRAF1 and its biological functions.
Volume: 597
Pages: 25-31
Publication
First Author: Irmler M
Year: 2000
Journal: FEBS Lett
Title: Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.
Volume: 468
Issue: 2-3
Pages: 129-33
Publication
First Author: Zhang B
Year: 2007
Journal: Blood
Title: NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis.
Volume: 110
Issue: 2
Pages: 743-51
Publication
First Author: Yamamoto H
Year: 2017
Journal: J Invest Dermatol
Title: TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis.
Volume: 137
Issue: 6
Pages: 1322-1332
Publication  
First Author: Lu YY
Year: 2013
Journal: Nat Commun
Title: TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.
Volume: 4
Pages: 2852
Publication
First Author: Speiser DE
Year: 1997
Journal: J Exp Med
Title: A regulatory role for TRAF1 in antigen-induced apoptosis of T cells.
Volume: 185
Issue: 10
Pages: 1777-83
Publication
First Author: Tsitsikov EN
Year: 2001
Journal: Immunity
Title: TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
Volume: 15
Issue: 4
Pages: 647-57
Publication
First Author: Oussa NA
Year: 2013
Journal: Biochem Biophys Res Commun
Title: TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells.
Volume: 432
Issue: 1
Pages: 129-34
Publication
First Author: Wang Q
Year: 2018
Journal: Cancer Res
Title: TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.
Volume: 78
Issue: 14
Pages: 3982-3994
Publication
First Author: Abdul-Sater AA
Year: 2017
Journal: Nat Immunol
Title: The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease.
Volume: 18
Issue: 1
Pages: 26-35
Publication
First Author: McPherson AJ
Year: 2012
Journal: J Biol Chem
Title: Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cells.
Volume: 287
Issue: 27
Pages: 23010-9
Publication
First Author: Bryce PJ
Year: 2006
Journal: Int Immunol
Title: TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
Volume: 18
Issue: 1
Pages: 101-11
Publication
First Author: Wang C
Year: 2012
Journal: J Exp Med
Title: Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
Volume: 209
Issue: 1
Pages: 77-91
Publication
First Author: Bin W
Year: 2019
Journal: Biochem Biophys Res Commun
Title: TRAF1 meditates lipopolysaccharide-induced acute lung injury by up regulating JNK activation.
Volume: 511
Issue: 1
Pages: 49-56
Publication
First Author: Bai W
Year: 2020
Journal: Cell Commun Signal
Title: TRAF1 suppresses antifungal immunity through CXCL1-mediated neutrophil recruitment during Candida albicans intradermal infection.
Volume: 18
Issue: 1
Pages: 30
Publication
First Author: Zheng C
Year: 2010
Journal: Mol Cell
Title: Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Volume: 38
Issue: 1
Pages: 101-13
Publication
First Author: Zapata JM
Year: 2002
Journal: Sci STKE
Title: TRAF1: lord without a RING.
Volume: 2002
Issue: 133
Pages: pe27
Protein
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Publication
First Author: Oyoshi MK
Year: 2007
Journal: Immunology
Title: TRAF1 regulates recruitment of lymphocytes and, to a lesser extent, neutrophils, myeloid dendritic cells and monocytes to the lung airways following lipopolysaccharide inhalation.
Volume: 120
Issue: 3
Pages: 303-14
Publication
First Author: Rothe M
Year: 1994
Journal: Cell
Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.
Volume: 78
Issue: 4
Pages: 681-92
Publication
First Author: Pryhuber GS
Year: 2005
Journal: Am J Pathol
Title: Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression.
Volume: 166
Issue: 6
Pages: 1637-45
Publication
First Author: Lee SY
Year: 1996
Journal: J Exp Med
Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.
Volume: 183
Issue: 2
Pages: 669-74
Publication
First Author: Sabbagh L
Year: 2008
Journal: J Immunol
Title: ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo.
Volume: 180
Issue: 12
Pages: 8093-101
Publication
First Author: Sabbagh L
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival.
Volume: 103
Issue: 49
Pages: 18703-8
Publication
First Author: Oyoshi MK
Year: 2008
Journal: J Immunol
Title: TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation.
Volume: 180
Issue: 3
Pages: 1878-85
Publication
First Author: Missiou A
Year: 2010
Journal: Circulation
Title: Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall.
Volume: 121
Issue: 18
Pages: 2033-44
Publication
First Author: Sabbagh L
Year: 2013
Journal: J Leukoc Biol
Title: Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.
Volume: 93
Issue: 5
Pages: 713-21
Publication
First Author: Rothe M
Year: 1995
Journal: Cell
Title: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
Volume: 83
Issue: 7
Pages: 1243-52
Publication
First Author: Xie P
Year: 2006
Journal: J Immunol
Title: Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.
Volume: 176
Issue: 9
Pages: 5388-400
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lai Y
Year: 2009
Journal: Nat Med
Title: Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
Volume: 15
Issue: 12
Pages: 1377-82
Publication
First Author: Ordway D
Year: 2005
Journal: J Immunol
Title: Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family.
Volume: 175
Issue: 6
Pages: 3873-81
GXD Expression      
Probe: MGI:5295240
Assay Type: RT-PCR
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5295625
Age: embryonic day 10.5
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5435190
Age: embryonic day 8.5
Image: 2
Specimen Label: 8.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5435190
Age: embryonic day 10.5
Image: 2
Specimen Label: 10.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:5435190
Age: embryonic day 11.5
Image: 2
Specimen Label: 11.5
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:5435190
Age: embryonic day 12.5
Image: 2
Specimen Label: 12.5
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:5435190
Age: embryonic day 13.5
Image: 2
Specimen Label: 13.5
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:5435190
Age: embryonic day 14.5
Image: 2
Specimen Label: 14.5
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:5435190
Age: embryonic day 15.5
Image: 2
Specimen Label: 15.5
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:5435190
Age: embryonic day 16.5
Image: 2
Specimen Label: 16.5
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:5435190
Age: embryonic day 17.5
Image: 2
Specimen Label: 17.5
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:1202925
Assay Type: Northern blot
Annotation Date: 2012-09-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:5435190
Age: embryonic day 18.5
Image: 2
Specimen Label: 18.5
Detected: false
Specimen Num: 11
GXD Expression
Probe: MGI:2664381
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1791721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:2664389
Age: embryonic day 13.5
Image: 2F
Note: Expression is in the outer edges of the invaginated tooth epithelium.
Specimen Label: 2F
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 0
Image: GUDMAP:14212
Specimen Label: GUDMAP:14212
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 2
Image: GUDMAP:14213
Specimen Label: GUDMAP:14213
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 4
Image: GUDMAP:14214
Specimen Label: GUDMAP:14214
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11544
Specimen Label: GUDMAP:11544
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11559
Specimen Label: GUDMAP:11559
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:2664381
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1829622
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:2664389
Age: embryonic day 14.5
Image: 2K
Note: Expression is in both the internal and external enamel epithelium.
Specimen Label: 2K
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:2664381
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1829623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:2664389
Age: embryonic day 15.5
Image: 2P
Note: Expression is in both internal and external enamel epithelium.
Specimen Label: 2P
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:2664381
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1735520
Stage: TS20
Assay Id: MGI:2664389
Age: embryonic day 12.5
Image: 2A
Note: Absent in mandible epithelium.
Specimen Label: 2A
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1794827
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 0
Image: GUDMAP:14212
Specimen Label: GUDMAP:14212
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1794827
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 2
Image: GUDMAP:14213
Specimen Label: GUDMAP:14213
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1794827
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 4
Image: GUDMAP:14214
Specimen Label: GUDMAP:14214
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:2664381
Assay Type: RNA in situ
Annotation Date: 2003-07-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1626219
Stage: TS19
Assay Id: MGI:2664389
Age: embryonic day 11.5
Specimen Label: Not Shown
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11544
Specimen Label: GUDMAP:11544
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11544
Specimen Label: GUDMAP:11544
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11559
Specimen Label: GUDMAP:11559
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11544
Specimen Label: GUDMAP:11544
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11559
Specimen Label: GUDMAP:11559
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1795027
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 0
Image: GUDMAP:14212
Specimen Label: GUDMAP:14212
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2767327
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 0
Image: GUDMAP:14212
Specimen Label: GUDMAP:14212
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2767327
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 2
Image: GUDMAP:14213
Specimen Label: GUDMAP:14213
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002140
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542694
Age: embryonic day 15.5
Image: GUDMAP:11544
Specimen Label: GUDMAP:11544
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1795227
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 0
Image: GUDMAP:14212
Specimen Label: GUDMAP:14212
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5508404
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1795227
Stage: TS27
Assay Id: MGI:5543116
Age: postnatal day 2
Image: GUDMAP:14213
Specimen Label: GUDMAP:14213
Detected: false
Specimen Num: 2