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Search results 4301 to 4400 out of 4422 for Ctnnb1

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Type Details Score
GXD Expression  
Probe: MGI:6712250
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282029
Age: embryonic day 16.5
Note: Prominent expression at cell-cell borders of secondary lens fibers in anterior of lens. Expression colocalized or adjacent to Ctnnb1 expression.
Specimen Label: 4C1a/b
Detected: true
Specimen Num: 1
Protein
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: false
Allele
Name: catenin beta 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Rolf Kemler
Allele Type: Targeted
Attribute String: Inserted expressed sequence
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 397  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: false
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1 Claus Nerlov
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
Protein Domain
Type: Family
Description: Adenomatous polyposis coli protein 2 (APC2) promotes rapid degradation of CTNNB1 (beta-catenin) and may function as a tumor suppressor. It may function in Wnt signaling [, , ].
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Markus Morkel
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
Allele
Name: transgene insertion 1, Jeffrey I Gordon
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
HT Experiment
Series Id: GSE27656
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 8.1, Mark A Magnussen
Allele Type: Targeted
Attribute String: Reporter, RMCE-ready
Genotype
Symbol: Cd19/Cd19<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: 129P2/OlaHsd * BALB/c
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mx1-cre)1Cgn/?
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Foxn1-cre)1Tbo/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Zp3-cre)93Knw/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cdx1-cre)23Kem/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Cdx1-cre)23Kem/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Kraus C
Year: 1994
Journal: Genomics
Title: Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development.
Volume: 23
Issue: 1
Pages: 272-4
Publication
First Author: Huff V
Year: 2011
Journal: Nat Rev Cancer
Title: Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.
Volume: 11
Issue: 2
Pages: 111-21
Publication
First Author: van Es JH
Year: 1999
Journal: Curr Biol
Title: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Volume: 9
Issue: 2
Pages: 105-8
Publication
First Author: Nakagawa H
Year: 1998
Journal: Cancer Res
Title: Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin.
Volume: 58
Issue: 22
Pages: 5176-81
Publication
First Author: Jarrett CR
Year: 2001
Journal: Cancer Res
Title: Human APC2 localization and allelic imbalance.
Volume: 61
Issue: 21
Pages: 7978-84
Publication
First Author: Kirstetter P
Year: 2006
Journal: Nat Immunol
Title: Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.
Volume: 7
Issue: 10
Pages: 1048-56
Publication
First Author: Sorcini D
Year: 2017
Journal: J Immunol
Title: Wnt/β-Catenin Signaling Induces Integrin α4β1 in T Cells and Promotes a Progressive Neuroinflammatory Disease in Mice.
Volume: 199
Issue: 9
Pages: 3031-3041
Publication
First Author: Riemer P
Year: 2015
Journal: Oncogene
Title: Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity.
Volume: 34
Issue: 24
Pages: 3164-75
Publication
First Author: Maimets M
Year: 2022
Journal: Nat Commun
Title: Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.
Volume: 13
Issue: 1
Pages: 715
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor H2az2/H2az2<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H2az2/H2az2<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Ding D
Year: 2023
Journal: Nat Commun
Title: Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.
Volume: 14
Issue: 1
Pages: 4671
Publication
First Author: Conner JM
Year: 2021
Journal: Science
Title: Modulation of tactile feedback for the execution of dexterous movement.
Volume: 374
Issue: 6565
Pages: 316-323
Publication
First Author: Sarris ME
Year: 2016
Journal: Cancer Cell
Title: Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.
Volume: 29
Issue: 3
Pages: 354-66
Publication
First Author: Ohrnberger S
Year: 2015
Journal: Hepatology
Title: Dysregulated serum response factor triggers formation of hepatocellular carcinoma.
Volume: 61
Issue: 3
Pages: 979-89
Publication      
First Author: Fitamant J
Year: 2015
Journal: Cell Rep
Title: YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
Publication
First Author: Mao W
Year: 2018
Journal: Cell Rep
Title: Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.
Volume: 23
Issue: 11
Pages: 3209-3222
Publication
First Author: Mohamed AD
Year: 2015
Journal: Biochim Biophys Acta
Title: The Hippo signal transduction pathway in soft tissue sarcomas.
Volume: 1856
Issue: 1
Pages: 121-9
Publication
First Author: Heino S
Year: 2021
Journal: Sci Adv
Title: Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Volume: 7
Issue: 47
Pages: eabj0512
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
Publication
First Author: Ortega AD
Year: 2010
Journal: J Cell Sci
Title: Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation.
Volume: 123
Issue: Pt 16
Pages: 2685-96
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of G3BP1, which has been identified as a phosphorylation-dependent endoribonuclease that interacts with the SH3 domain of RasGAP []. However, this interaction has been questioned []. G3BP1 binds to and cleaves the 3'-untranslated region (3'-UTR) of the c-myc mRNA in a phosphorylation-dependent manner []. G3BP1 has been linked to the formation of stress granules (SGs), membrane-less structures consisting of mRNA and protein aggregates form rapidly in response to a wide range of stresses and viral infections [, ]. G3BP1 is targeted by many viruses and may be involved in innate immune response [, ]. Its activities can be regulated through post-translational modifications [].It has also been shown that G3BP1 is a novel Dishevelled-associated protein that is methylated upon Wnt3a stimulation and that arginine methylation of G3BP1 regulates both Ctnnb1 mRNA and canonical Wnt/beta-catenin signaling []. Furthermore, G3BP1 can be associated with the 3'-UTR of beta-F1 mRNA in cytoplasmic RNA-granules, demonstrating that G3BP1 may specifically repress the translation of the transcript [].G3BP1 contains an N-terminal nuclear transfer factor 2 (NTF2)-like domain, an RNA recognition motif (RRM domain), and an Arg-Gly-rich region (RGG-rich region, or arginine methylation motif). The RRM domain and RGG-rich region are canonically associated with RNA binding [].
Genotype
Symbol: Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor Edil3/Edil3<+>
Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Abedini A
Year: 2020
Journal: Sci Rep
Title: Non-canonical WNT5a regulates Epithelial-to-Mesenchymal Transition in the mouse ovarian surface epithelium.
Volume: 10
Issue: 1
Pages: 9695
Publication
First Author: Tu HC
Year: 2015
Journal: Genes Dev
Title: LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.
Volume: 29
Issue: 10
Pages: 1074-86
Publication
First Author: Abedini A
Year: 2016
Journal: FASEB J
Title: WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
Volume: 30
Issue: 4
Pages: 1534-47
Publication      
First Author: Kong Y
Year: 2018
Journal: Hum Mol Genet
Title: A FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency.
Publication
First Author: Gerner-Mauro KN
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors.
Volume: 117
Issue: 22
Pages: 12182-12191
Publication
First Author: Hilkens J
Year: 2017
Journal: Gut
Title: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis.
Volume: 66
Issue: 6
Pages: 1095-1105
Publication
First Author: Song X
Year: 2022
Journal: Int J Biol Sci
Title: Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells.
Volume: 18
Issue: 2
Pages: 652-660
Publication
First Author: Deming DA
Year: 2014
Journal: Oncogene
Title: PIK3CA and APC mutations are synergistic in the development of intestinal cancers.
Volume: 33
Issue: 17
Pages: 2245-54
Publication
First Author: Isoda T
Year: 2014
Journal: Int J Biol Sci
Title: Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice.
Volume: 10
Issue: 8
Pages: 940-7
Publication
First Author: Yueh AE
Year: 2016
Journal: PLoS One
Title: Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.
Volume: 11
Issue: 2
Pages: e0148730
Publication
First Author: Hayashi K
Year: 2011
Journal: Biol Reprod
Title: WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development.
Volume: 84
Issue: 2
Pages: 308-19
Publication  
First Author: Dai W
Year: 2022
Journal: J Clin Invest
Title: Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.
Volume: 132
Issue: 24
Publication
First Author: Essien BE
Year: 2016
Journal: Cancer Res
Title: Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.
Volume: 76
Issue: 23
Pages: 6877-6887
Publication  
First Author: Roy S
Year: 2022
Journal: Endocrinology
Title: Jumonji Domain-containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility.
Volume: 163
Issue: 5
Publication
First Author: Gamaev L
Year: 2021
Journal: Oncogene
Title: The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.
Volume: 40
Issue: 1
Pages: 127-139
Publication
First Author: Hankey W
Year: 2018
Journal: Cancer Res
Title: Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients.
Volume: 78
Issue: 3
Pages: 617-630
Publication
First Author: Piao J
Year: 2013
Journal: Int J Biol Sci
Title: Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis.
Volume: 10
Issue: 1
Pages: 73-9
Publication  
First Author: Xiong Y
Year: 2022
Journal: Cell Signal
Title: FOXO1 differentially regulates bone formation in young and aged mice.
Volume: 99
Pages: 110438
Publication
First Author: Kas K
Year: 1997
Journal: Nat Genet
Title: Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations.
Volume: 15
Issue: 2
Pages: 170-4
Publication
First Author: Katoh M
Year: 2003
Journal: Int J Oncol
Title: Identification and characterization of TPARM gene in silico.
Volume: 23
Issue: 4
Pages: 1213-7
Publication
First Author: Strathmann J
Year: 2007
Journal: Proteomics
Title: Proteome analysis of chemically induced mouse liver tumors with different genotype.
Volume: 7
Issue: 18
Pages: 3318-31
Publication
First Author: Unterberger EB
Year: 2014
Journal: Int J Cancer
Title: Ha-ras and β-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors.
Volume: 135
Issue: 7
Pages: 1574-85
Publication
First Author: Schneider AJ
Year: 2014
Journal: Toxicol Sci
Title: In utero exposure to TCDD alters Wnt signaling during mouse prostate development: linking ventral prostate agenesis to downregulated β-catenin signaling.
Volume: 141
Issue: 1
Pages: 176-87
Publication
First Author: Puliga E
Year: 2017
Journal: Am J Pathol
Title: Thyroid Hormone Receptor-β Agonist GC-1 Inhibits Met-β-Catenin-Driven Hepatocellular Cancer.
Volume: 187
Issue: 11
Pages: 2473-2485
Publication
First Author: Wang W
Year: 2019
Journal: Mol Cancer Res
Title: Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling.
Volume: 17
Issue: 2
Pages: 521-531
Publication
First Author: Kajino-Sakamoto R
Year: 2021
Journal: Oncogene
Title: Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells.
Volume: 40
Issue: 2
Pages: 408-420
Publication
First Author: Xiang L
Year: 2020
Journal: Stem Cell Res Ther
Title: FOXQ1 promotes the osteogenic differentiation of bone mesenchymal stem cells via Wnt/β-catenin signaling by binding with ANXA2.
Volume: 11
Issue: 1
Pages: 403
Publication
First Author: Han F
Year: 2021
Journal: Aging Cell
Title: Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation.
Volume: 20
Issue: 5
Pages: e13343
Publication
First Author: Tong K
Year: 2021
Journal: Oncogene
Title: SMAD4 is critical in suppression of BRAF-V600E serrated tumorigenesis.
Volume: 40
Issue: 41
Pages: 6034-6048
Publication
First Author: Trowe MO
Year: 2012
Journal: Development
Title: Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Volume: 139
Issue: 17
Pages: 3099-108
Publication
First Author: Williams R
Year: 2022
Journal: Oncogene
Title: Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia.
Volume: 41
Issue: 7
Pages: 1040-1049
Publication
First Author: Ito K
Year: 2022
Journal: Sci Rep
Title: Efficacy of auranofin as an inhibitor of desmoid progression.
Volume: 12
Issue: 1
Pages: 11918
Publication
First Author: Sinha S
Year: 2023
Journal: Nat Commun
Title: Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.
Volume: 14
Issue: 1
Pages: 2651