Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802101 |
|
Specimen Label: |
JAX_1802101 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1775928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802102 |
|
Specimen Label: |
JAX_1802102 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1737328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802103 |
Note: |
kidney |
Specimen Label: |
JAX_1802103 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1619828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802104 |
|
Specimen Label: |
JAX_1802104 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802105 |
|
Specimen Label: |
JAX_1802105 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1842628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802106 |
|
Specimen Label: |
JAX_1802106 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802107 |
|
Specimen Label: |
JAX_1802107 |
Detected: |
true |
Specimen Num: |
23 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1881228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802108 |
|
Specimen Label: |
JAX_1802108 |
Detected: |
true |
Specimen Num: |
24 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802109 |
|
Specimen Label: |
JAX_1802109 |
Detected: |
true |
Specimen Num: |
25 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1672828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802110 |
|
Specimen Label: |
JAX_1802110 |
Detected: |
true |
Specimen Num: |
26 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802111 |
|
Specimen Label: |
JAX_1802111 |
Detected: |
true |
Specimen Num: |
27 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1685328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802112 |
|
Specimen Label: |
JAX_1802112 |
Detected: |
true |
Specimen Num: |
28 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692087 |
Age: |
postnatal adult |
Image: |
JAX_1802113 |
|
Specimen Label: |
JAX_1802113 |
Detected: |
true |
Specimen Num: |
29 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6178252 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-11-28 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3583128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7561607 |
Age: |
postnatal day 56 |
Image: |
S3 |
|
Specimen Label: |
S3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osada N |
Year: |
2000 |
Journal: |
GenBank Submission |
Title: |
Mus musculus brain cDNA, clone MNCb-5203 |
|
|
Pages: |
AB041606 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
613
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
619
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoffers DA |
Year: |
1991 |
Journal: |
J Biol Chem |
Title: |
Characterization of novel mRNAs encoding enzymes involved in peptide alpha-amidation. |
Volume: |
266 |
Issue: |
3 |
Pages: |
1701-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ouafik LH |
Year: |
1992 |
Journal: |
Mol Endocrinol |
Title: |
The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. |
Volume: |
6 |
Issue: |
10 |
Pages: |
1571-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prigge ST |
Year: |
2000 |
Journal: |
Cell Mol Life Sci |
Title: |
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. |
Volume: |
57 |
Issue: |
8-9 |
Pages: |
1236-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klinman JP |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation. |
Volume: |
281 |
Issue: |
6 |
Pages: |
3013-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang N |
Year: |
2000 |
Journal: |
Dev Biol |
Title: |
PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. |
Volume: |
226 |
Issue: |
1 |
Pages: |
118-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han M |
Year: |
2004 |
Journal: |
J Neurochem |
Title: |
Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. |
Volume: |
90 |
Issue: |
1 |
Pages: |
129-41 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
In vertebrates, peptidylglycine alpha-amidating monooxygenase (PAM) is a multifunctional protein found in secretory granules. The protein contains two enzymes, peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL), that act sequentially to catalyse the alpha-amidation of neuroendocrine peptides [, ]: peptidylglycine + ascorbate + O2= peptidyl-(2-hydroxyglycine) + dehydroascorbate + H2OThe product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide. The first step of the reaction is catalysed by peptidylglycine alpha-hydroxylating monooxygenase (PHM), and is dependent on copper, ascorbate and molecular oxygen; peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) catalyses the second step of the reaction []. PHM share protein sequence similarity with dopamine-beta-monooxygenases (DBH), a class of ascorbate-dependent enzymes that requires copper as a cofactor and uses ascorbate as an electron donor. PHM and DBH share a few regions of sequence similarity, some of which contain clusters of conserved histidine residues that may be involved in copper binding [, ].Interestingly, in Drosophila, the PHM and PAL enzyme are not fused. The Drosophila genome predicts expression of one monofunctional PHM gene and two monofunctional PAL genes []. Drosophila PHM encodes an active enzyme that is required for peptide amidation in vivo [], while both PAL proteins display PAL enzymatic activity and are involved in neuroendocrine biosynthesis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Isingrini E |
Year: |
2016 |
Journal: |
J Psychiatry Neurosci |
Title: |
Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour. |
Volume: |
41 |
Issue: |
3 |
Pages: |
169-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sumi-Ichinose C |
Year: |
2005 |
Journal: |
J Neurochem |
Title: |
Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. |
Volume: |
95 |
Issue: |
3 |
Pages: |
703-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Homma D |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain. |
Volume: |
286 |
Issue: |
2 |
Pages: |
1445-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stornetta RL |
Year: |
2013 |
Journal: |
Brain Struct Funct |
Title: |
Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas. |
Volume: |
218 |
Issue: |
2 |
Pages: |
455-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abe C |
Year: |
2017 |
Journal: |
Nat Neurosci |
Title: |
C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. |
Volume: |
20 |
Issue: |
5 |
Pages: |
700-707 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Publication |
First Author: |
Fell SM |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA. |
Volume: |
31 |
Issue: |
10 |
Pages: |
1036-1053 |
|
•
•
•
•
•
|
Publication |
First Author: |
Van C |
Year: |
2019 |
Journal: |
J Mol Neurosci |
Title: |
PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. |
Volume: |
68 |
Issue: |
3 |
Pages: |
439-451 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olivas A |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130. |
Volume: |
36 |
Issue: |
2 |
Pages: |
479-88 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Molenaar JJ |
Year: |
2012 |
Journal: |
Nat Genet |
Title: |
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. |
Volume: |
44 |
Issue: |
11 |
Pages: |
1199-206 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ziegler KA |
Year: |
2023 |
Journal: |
Science |
Title: |
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. |
Volume: |
381 |
Issue: |
6655 |
Pages: |
285-290 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Parlato R |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Conditional inactivation of glucocorticoid receptor gene in dopamine-beta-hydroxylase cells impairs chromaffin cell survival. |
Volume: |
150 |
Issue: |
4 |
Pages: |
1775-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Potzner MR |
Year: |
2010 |
Journal: |
Development |
Title: |
Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. |
Volume: |
137 |
Issue: |
5 |
Pages: |
775-84 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Creb1/Creb1 Crem/Crem Tg(Dbh-icre)1Gsc/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Sox11/Sox11 Sox4/Sox4 Tg(Dbh-icre)1Gsc/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(DBH-PTPN11)33Bmas/? |
Background: |
Not Specified |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gata3/Gata3 Tg(Dbh-icre)1Gsc/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gata3/Gata3 Tg(Dbh-cre/ERT2)198.1Hroh/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Tg(Dbh-icre)1Gsc/? Tg(Th-MYCN)41Waw/? |
Background: |
involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gal/Gal Dbh/Dbh<+> |
Background: |
B6.Cg-Dbh Gal |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dbh-cre)KH212Gsat/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * FVB/NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dbh-icre)1Gsc/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dbh-cre/ERT2)198.1Hroh/? |
Background: |
involves: 129S4/SvJaeSor * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dbh/Dbh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama M |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation. |
Volume: |
59 |
Issue: |
1 |
Pages: |
40-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson CS |
Year: |
2018 |
Journal: |
J Comp Neurol |
Title: |
Neurotransmitter diversity in pre-synaptic terminals located in the parvicellular neuroendocrine paraventricular nucleus of the rat and mouse hypothalamus. |
Volume: |
526 |
Issue: |
8 |
Pages: |
1287-1306 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsushita N |
Year: |
2004 |
Journal: |
J Neurosci Res |
Title: |
Fate of transient catecholaminergic cell types revealed by site-specific recombination in transgenic mice. |
Volume: |
78 |
Issue: |
1 |
Pages: |
7-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Z |
Year: |
2006 |
Journal: |
BMC Neurosci |
Title: |
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. |
Volume: |
7 |
|
Pages: |
29 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sourris KC |
Year: |
2012 |
Journal: |
Free Radic Biol Med |
Title: |
Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. |
Volume: |
52 |
Issue: |
3 |
Pages: |
716-723 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adachi M |
Year: |
2000 |
Journal: |
DNA Cell Biol |
Title: |
Paired-like homeodomain proteins Phox2a/Arix and Phox2b/NBPhox have similar genetic organization and independently regulate dopamine beta-hydroxylase gene transcription. |
Volume: |
19 |
Issue: |
9 |
Pages: |
539-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishiguro H |
Year: |
1998 |
Journal: |
J Biol Chem |
Title: |
Identification and characterization of a novel phorbol ester-responsive DNA sequence in the 5'-flanking region of the human dopamine beta-hydroxylase gene. |
Volume: |
273 |
Issue: |
34 |
Pages: |
21941-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayerhofer A |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Oocytes are a source of catecholamines in the primate ovary: evidence for a cell-cell regulatory loop. |
Volume: |
95 |
Issue: |
18 |
Pages: |
10990-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmidt M |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The bHLH transcription factor Hand2 is essential for the maintenance of noradrenergic properties in differentiated sympathetic neurons. |
Volume: |
329 |
Issue: |
2 |
Pages: |
191-200 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim S |
Year: |
2014 |
Journal: |
Exp Neurol |
Title: |
Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress. |
Volume: |
252 |
|
Pages: |
63-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi K |
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1992 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Genetic alteration of catecholamine specificity in transgenic mice. |
Volume: |
89 |
Issue: |
5 |
Pages: |
1631-5 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
622
|
Fragment?: |
false |
|
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•
•
•
•
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Publication |
First Author: |
van den Berg MP |
Year: |
2018 |
Journal: |
Circ Res |
Title: |
Mutations in CYB561 Causing a Novel Orthostatic Hypotension Syndrome. |
Volume: |
122 |
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6 |
Pages: |
846-854 |
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•
•
•
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Publication |
First Author: |
Kim CH |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. |
Volume: |
274 |
Issue: |
10 |
Pages: |
6507-18 |
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•
•
•
•
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Publication |
First Author: |
Schwarz LA |
Year: |
2015 |
Journal: |
Nature |
Title: |
Viral-genetic tracing of the input-output organization of a central noradrenaline circuit. |
Volume: |
524 |
Issue: |
7563 |
Pages: |
88-92 |
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•
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Publication |
First Author: |
Beas BS |
Year: |
2018 |
Journal: |
Nat Neurosci |
Title: |
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. |
Volume: |
21 |
Issue: |
7 |
Pages: |
963-973 |
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•
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•
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Publication |
First Author: |
Hasan W |
Year: |
2012 |
Journal: |
Neurosci Lett |
Title: |
Altered atrial neurotransmitter release in transgenic p75(-/-) and gp130 KO mice. |
Volume: |
529 |
Issue: |
1 |
Pages: |
55-9 |
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•
•
•
•
|
Publication |
First Author: |
Kanazawa H |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. |
Volume: |
120 |
Issue: |
2 |
Pages: |
408-21 |
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•
•
•
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Publication |
First Author: |
Parlato R |
Year: |
2010 |
Journal: |
J Neurochem |
Title: |
Effects of the cell type-specific ablation of the cAMP-responsive transcription factor in noradrenergic neurons on locus coeruleus firing and withdrawal behavior after chronic exposure to morphine. |
Volume: |
115 |
Issue: |
3 |
Pages: |
563-73 |
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•
•
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Publication |
First Author: |
Dougherty SE |
Year: |
2020 |
Journal: |
Exp Neurol |
Title: |
Catecholaminergic axons in the neocortex of adult mice regrow following brain injury. |
Volume: |
323 |
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Pages: |
113089 |
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•
•
|
Publication |
First Author: |
Meng Q |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood. |
Volume: |
13 |
Issue: |
1 |
Pages: |
3077 |
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•
•
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Publication |
First Author: |
Isingrini E |
Year: |
2016 |
Journal: |
Nat Neurosci |
Title: |
Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. |
Volume: |
19 |
Issue: |
4 |
Pages: |
560-3 |
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•
•
•
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Publication |
First Author: |
François M |
Year: |
2019 |
Journal: |
Ann N Y Acad Sci |
Title: |
Sympathetic innervation of the interscapular brown adipose tissue in mouse. |
Volume: |
1454 |
Issue: |
1 |
Pages: |
3-13 |
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•
•
•
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Publication |
First Author: |
Losacco J |
Year: |
2020 |
Journal: |
Elife |
Title: |
Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb. |
Volume: |
9 |
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•
•
•
•
•
|
Publication |
First Author: |
Ramirez-Gordillo D |
Year: |
2018 |
Journal: |
Front Cell Neurosci |
Title: |
Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. |
Volume: |
12 |
|
Pages: |
48 |
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•
•
•
•
|
Publication |
First Author: |
Sweetser DA |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Ganglioneuromas and renal anomalies are induced by activated RET(MEN2B) in transgenic mice. |
Volume: |
18 |
Issue: |
4 |
Pages: |
877-86 |
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•
•
•
•
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Publication |
First Author: |
Chen B |
Year: |
2002 |
Journal: |
Dev Biol |
Title: |
SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons. |
Volume: |
252 |
Issue: |
2 |
Pages: |
170-87 |
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•
•
•
•
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Publication |
First Author: |
Heukamp LC |
Year: |
2012 |
Journal: |
Sci Transl Med |
Title: |
Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. |
Volume: |
4 |
Issue: |
141 |
Pages: |
141ra91 |
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•
•
•
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Publication |
First Author: |
Busquets-Garcia A |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. |
Volume: |
113 |
Issue: |
35 |
Pages: |
9904-9 |
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•
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Publication |
First Author: |
Majdazari A |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling. |
Volume: |
33 |
Issue: |
38 |
Pages: |
15132-44 |
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•
•
•
•
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Publication |
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Yin X |
Year: |
2021 |
Journal: |
Nat Neurosci |
Title: |
Delayed motor learning in a 16p11.2 deletion mouse model of autism is rescued by locus coeruleus activation. |
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•
•
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Publication |
First Author: |
Liu Y |
Year: |
2017 |
Journal: |
Neuron |
Title: |
Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation. |
Volume: |
93 |
Issue: |
2 |
Pages: |
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•
•
•
•
|
Publication |
First Author: |
Rajan I |
Year: |
2001 |
Journal: |
Pediatr Dev Pathol |
Title: |
RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. |
Volume: |
4 |
Issue: |
5 |
Pages: |
446-53 |
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•
•
•
•
|
Publication |
First Author: |
Mukai Y |
Year: |
2023 |
Journal: |
J Neurosci |
Title: |
Prostaglandin E(2) Induces Long-Lasting Inhibition of Noradrenergic Neurons in the Locus Coeruleus and Moderates the Behavioral Response to Stressors. |
Volume: |
43 |
Issue: |
47 |
Pages: |
7982-7999 |
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Publication |
First Author: |
Scott-Solomon E |
Year: |
2020 |
Journal: |
Dev Cell |
Title: |
Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth. |
Volume: |
53 |
Issue: |
6 |
Pages: |
691-705.e7 |
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Publication |
First Author: |
Stanke M |
Year: |
2006 |
Journal: |
Development |
Title: |
Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. |
Volume: |
133 |
Issue: |
1 |
Pages: |
141-50 |
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•
•
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•
•
|
Publication |
First Author: |
Parrish DC |
Year: |
2009 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Absence of gp130 in dopamine beta-hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias. |
Volume: |
297 |
Issue: |
3 |
Pages: |
H960-7 |
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•
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•
•
|
Publication |
First Author: |
Li S |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hypocretin/Orexin receptor 1-KO mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
15474 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Atf1/Atf1 Creb1/Creb1 Tg(Dbh-icre)1Gsc/? |
Background: |
involves: 129 * 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Egr3/Egr3 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dbh-cre)KH212Gsat/? |
Background: |
involves: C57BL/6 * FVB/NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Clstn3/Clstn3 Tg(Dbh-cre)KH212Gsat/? |
Background: |
involves: C57BL/6 * C57BL/6N * FVB/NTac * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dbh/Dbh<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6NCrl |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka S |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury. |
Volume: |
118 |
Issue: |
12 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez VK |
Year: |
2019 |
Journal: |
Front Physiol |
Title: |
Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels. |
Volume: |
10 |
|
Pages: |
521 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Wilde B |
Year: |
2018 |
Journal: |
Oncotarget |
Title: |
The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease. |
Volume: |
9 |
Issue: |
9 |
Pages: |
8334-8349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao Z |
Year: |
2017 |
Journal: |
Neuron |
Title: |
A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. |
Volume: |
95 |
Issue: |
1 |
Pages: |
138-152.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aravind L |
Year: |
2001 |
Journal: |
Trends Biochem Sci |
Title: |
DOMON: an ancient extracellular domain in dopamine beta-monooxygenase and other proteins. |
Volume: |
26 |
Issue: |
9 |
Pages: |
524-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Travers S |
Year: |
2018 |
Journal: |
J Comp Neurol |
Title: |
Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract. |
Volume: |
526 |
Issue: |
14 |
Pages: |
2319-2338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Breton-Provencher V |
Year: |
2019 |
Journal: |
Nat Neurosci |
Title: |
Active control of arousal by a locus coeruleus GABAergic circuit. |
Volume: |
22 |
Issue: |
2 |
Pages: |
218-228 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jackson MZ |
Year: |
2014 |
Journal: |
Development |
Title: |
A neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation. |
Volume: |
141 |
Issue: |
12 |
Pages: |
2452-61 |
|
•
•
•
•
•
|