Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1646922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1736222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1683322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1700022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1832122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the immune system. |
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1833322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3287022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1821522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1702122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428959 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422711 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EN2531; Specimen N1025 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barallobre MJ |
Year: |
2014 |
Journal: |
Cell Death Dis |
Title: |
DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. |
Volume: |
5 |
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Pages: |
e1289 |
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•
•
•
•
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Publication |
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Pagliarini DJ |
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Cell |
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A mitochondrial protein compendium elucidates complex I disease biology. |
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•
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Publication |
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2003 |
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Proc Natl Acad Sci U S A |
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
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9918-22 |
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•
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Publication |
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2004 |
Journal: |
Nucleic Acids Res |
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GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
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Database issue |
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D552-6 |
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•
•
•
•
|
Publication |
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Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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•
•
•
•
•
|
Publication |
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GOA curators |
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2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
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Magdaleno S |
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2006 |
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PLoS Biol |
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
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4 |
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4 |
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e86 |
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•
•
•
•
•
|
Publication |
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Mouse Genome Informatics Scientific Curators |
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2003 |
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Title: |
MGI Sequence Curation Reference |
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•
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Publication |
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Science |
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The transcriptional landscape of the mammalian genome. |
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5740 |
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1559-63 |
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•
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•
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Nature |
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Functional annotation of a full-length mouse cDNA collection. |
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•
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Publication |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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Publication |
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Zambrowicz BP |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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14109-14 |
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Title: |
GemPharmatech Website. |
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AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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Mouse Genome Informatics Scientific Curators |
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2010 |
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Human to Mouse ISO GO annotation transfer |
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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MGI Genome Annotation Group and UniGene Staff |
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Database Download |
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MGI-UniGene Interconnection Effort |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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2010 |
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Annotation inferences using phylogenetic trees |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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Database Download |
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Consensus CDS project |
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Mouse Genome Informatics |
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Database Release |
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Protein Ontology Association Load. |
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Publication |
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Mouse Genome Database and National Center for Biotechnology Information |
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Database Release |
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Entrez Gene Load |
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Publication |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics Group |
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Database Procedure |
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Automatic Encodes (AutoE) Reference |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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•
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•
•
•
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DO Term |
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•
•
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Publication |
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J Biol Chem |
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Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase. |
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279 |
Issue: |
33 |
Pages: |
34833-9 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units []. The C-terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae (). Met 224 is also thought to play a role in copper transfer or stabilising the copper site []. |
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•
•
•
•
•
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Protein Domain |
Type: |
Homologous_superfamily |
Description: |
Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein. In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. Thisis essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre. Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units []. The C-terminal region of the protein is known to form a dimer. Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae (). Met 224 is also thought to play a role in copper transfer or stabilising the copper site [].The copper binding motif is composed of two highly conserved cysteines and is located on one side of a β-barrel structure []. |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
275
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Hiser L |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Cox11p is required for stable formation of the Cu(B) and magnesium centers of cytochrome c oxidase. |
Volume: |
275 |
Issue: |
1 |
Pages: |
619-23 |
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•
•
•
•
•
|
Publication |
First Author: |
Carr HS |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Yeast Cox11, a protein essential for cytochrome c oxidase assembly, is a Cu(I)-binding protein. |
Volume: |
277 |
Issue: |
34 |
Pages: |
31237-42 |
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•
•
•
•
•
|
Publication |
First Author: |
Guo D |
Year: |
2005 |
Journal: |
Mol Pain |
Title: |
Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. |
Volume: |
1 |
|
Pages: |
15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khalimonchuk O |
Year: |
2006 |
Journal: |
Eukaryot Cell |
Title: |
Sequential processing of a mitochondrial tandem protein: insights into protein import in Schizosaccharomyces pombe. |
Volume: |
5 |
Issue: |
7 |
Pages: |
997-1006 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the genetic information. Incoming amino acid monomers enter the ribosomal A site in the form of aminoacyl-tRNAs complexed with elongation factor Tu (EF-Tu) and GTP. The growing polypeptide chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated to the P site with the aid the elongation factor G (EF-G) and GTP as the deacylated tRNA is released from the ribosome through one or more exit sites [, ]. About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. The proteins are named in accordance with the subunit of the ribosome which they belong to - the small (S1 to S31) and the large (L1 to L44). Usually they decorate the rRNA cores of the subunits. Many ribosomal proteins, particularly those of the large subunit, are composed of a globular, surfaced-exposed domain with long finger-like projections that extend into the rRNA core to stabilise its structure. Most of the proteins interact with multiple RNA elements, often from different domains. In the large subunit, about 1/3 of the 23S rRNA nucleotides are at least in van der Waal's contact with protein, and L22 interacts with all six domains of the 23S rRNA. Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. In this way proteins serve to organise and stabilise the rRNA tertiary structure. While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. In addition to their function in the ribosome, many ribosomal proteins have some function 'outside' the ribosome [, ].Rsm22 has been identified as a mitochondrial small ribosomal subunit []and is a methyltransferase. In Schizosaccharomyces pombe (Fission yeast), Rsm22 is tandemly fused to Cox11 (a factor required for copper insertion into cytochrome oxidase) and the two proteins are proteolytically cleaved after import into the mitochondria []. This entry consists of mitochondrial Rsm22 and homologous sequences from bacteria. |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
280
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
236
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
486
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramakrishnan V |
Year: |
2001 |
Journal: |
Curr Opin Struct Biol |
Title: |
Atomic structures at last: the ribosome in 2000. |
Volume: |
11 |
Issue: |
2 |
Pages: |
144-54 |
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•
•
•
•
•
|
Publication |
First Author: |
Maguire BA |
Year: |
2001 |
Journal: |
Cell |
Title: |
The ribosome in focus. |
Volume: |
104 |
Issue: |
6 |
Pages: |
813-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandra Sanyal S |
Year: |
2000 |
Journal: |
Curr Opin Struct Biol |
Title: |
The end of the beginning: structural studies of ribosomal proteins. |
Volume: |
10 |
Issue: |
6 |
Pages: |
633-6 |
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•
•
•
•
•
|