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Search results 101 to 200 out of 954 for Lrrk2

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Type Details Score
Publication
First Author: Herzig MC
Year: 2012
Journal: PLoS One
Title: High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain.
Volume: 7
Issue: 5
Pages: e36581
Publication
First Author: Mazza MC
Year: 2021
Journal: J Parkinsons Dis
Title: Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo.
Volume: 11
Issue: 2
Pages: 569-584
Publication    
First Author: Dhekne HS
Year: 2023
Journal: Elife
Title: Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.
Volume: 12
Publication
First Author: Araki M
Year: 2021
Journal: Hum Mol Genet
Title: BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice.
Volume: 30
Issue: 17
Pages: 1618-1631
Publication  
First Author: Heaton GR
Year: 2020
Journal: Neurobiol Dis
Title: Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
Volume: 141
Pages: 104948
Publication  
First Author: Liu Y
Year: 2022
Journal: Free Radic Biol Med
Title: LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway.
Volume: 191
Pages: 119-127
Publication
First Author: Ludtmann MHR
Year: 2019
Journal: Cell Death Dis
Title: LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.
Volume: 10
Issue: 4
Pages: 265
Publication
First Author: Liu HF
Year: 2014
Journal: Ann Clin Transl Neurol
Title: LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity.
Volume: 1
Issue: 3
Pages: 199-208
Publication  
First Author: Liu HF
Year: 2017
Journal: Sci Rep
Title: Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
Volume: 7
Pages: 40887
Publication
First Author: Xiong Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.
Volume: 115
Issue: 7
Pages: 1635-1640
Publication
First Author: Lobbestael E
Year: 2013
Journal: Biochem J
Title: Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
Volume: 456
Issue: 1
Pages: 119-28
Publication
First Author: Stafa K
Year: 2012
Journal: PLoS Genet
Title: GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.
Volume: 8
Issue: 2
Pages: e1002526
Publication
First Author: Zhang M
Year: 2019
Journal: J Transl Med
Title: LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production.
Volume: 17
Issue: 1
Pages: 37
Publication
First Author: Ma B
Year: 2016
Journal: Hum Mol Genet
Title: LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.
Volume: 25
Issue: 16
Pages: 3515-3523
Publication
First Author: Nguyen APT
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Volume: 117
Issue: 29
Pages: 17296-17307
Publication  
First Author: Schapansky J
Year: 2018
Journal: Neurobiol Dis
Title: Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Volume: 111
Pages: 26-35
Publication
First Author: Berwick DC
Year: 2012
Journal: Hum Mol Genet
Title: LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Volume: 21
Issue: 22
Pages: 4966-79
Publication
First Author: Trancikova A
Year: 2012
Journal: PLoS One
Title: Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
Volume: 7
Issue: 10
Pages: e47784
Publication
First Author: Berwick DC
Year: 2017
Journal: Mol Neurodegener
Title: Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling.
Volume: 12
Issue: 1
Pages: 9
Publication    
First Author: Volta M
Year: 2017
Journal: Elife
Title: Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.
Volume: 6
Publication
First Author: Beilina A
Year: 2020
Journal: Cell Rep
Title: The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
Volume: 31
Issue: 5
Pages: 107614
Publication
First Author: Tozzi A
Year: 2018
Journal: Cell Death Dis
Title: Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease.
Volume: 9
Issue: 2
Pages: 204
Publication
First Author: Liu Z
Year: 2011
Journal: Nat Immunol
Title: The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Volume: 12
Issue: 11
Pages: 1063-70
Publication
First Author: Guevara CA
Year: 2020
Journal: J Neurophysiol
Title: LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.
Volume: 123
Issue: 6
Pages: 2382-2389
Publication    
First Author: Dhekne HS
Year: 2018
Journal: Elife
Title: A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Volume: 7
Publication
First Author: Herzig MC
Year: 2011
Journal: Hum Mol Genet
Title: LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Volume: 20
Issue: 21
Pages: 4209-23
Publication  
First Author: Tozzi A
Year: 2018
Journal: Neurobiol Dis
Title: Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease.
Volume: 118
Pages: 1-8
Publication  
First Author: Hinkle KM
Year: 2012
Journal: Mol Neurodegener
Title: LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors.
Volume: 7
Pages: 25
Publication
First Author: Levy DR
Year: 2020
Journal: J Biol Chem
Title: The Parkinson's disease-associated kinase LRRK2 regulates genes required for cell adhesion, polarization, and chemotaxis in activated murine macrophages.
Volume: 295
Issue: 31
Pages: 10857-10867
Publication
First Author: Pajarillo E
Year: 2023
Journal: J Biol Chem
Title: The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction.
Volume: 299
Issue: 7
Pages: 104879
Publication
First Author: Li X
Year: 2011
Journal: PLoS One
Title: Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Volume: 6
Issue: 3
Pages: e17153
Publication
First Author: Guaitoli G
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Volume: 113
Issue: 30
Pages: E4357-66
Publication
First Author: Malik AU
Year: 2021
Journal: Biochem J
Title: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
Volume: 478
Issue: 3
Pages: 553-578
Publication
First Author: Eguchi T
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis.
Volume: 115
Issue: 39
Pages: E9115-E9124
Publication  
First Author: Longo F
Year: 2014
Journal: Neurobiol Dis
Title: Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
Volume: 71
Pages: 62-73
Publication  
First Author: Albanese F
Year: 2021
Journal: Neurobiol Dis
Title: Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Volume: 159
Pages: 105487
Publication
First Author: Mazaki Y
Year: 2023
Journal: Cell Commun Signal
Title: LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.
Volume: 21
Issue: 1
Pages: 300
Publication
First Author: Dzamko N
Year: 2010
Journal: Biochem J
Title: Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.
Volume: 430
Issue: 3
Pages: 405-13
Publication
First Author: Nabar NR
Year: 2022
Journal: Autophagy
Title: LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Volume: 18
Issue: 1
Pages: 204-222
GXD Expression  
Probe: MGI:7495561
Assay Type: RNA in situ
Annotation Date: 2023-07-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7506541
Age: postnatal
Note: There was a high overlap of Lrrk2 mRNA expressing cells with Rbfox3.
Specimen Label: not shown NeuN
Detected: true
Specimen Num: 3
Publication
First Author: Lanning NJ
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: LRRK2 deficiency impairs trans-Golgi to lysosome trafficking and endocytic cargo degradation in human renal proximal tubule epithelial cells.
Volume: 315
Issue: 5
Pages: F1465-F1477
Publication
First Author: Dusonchet J
Year: 2014
Journal: Hum Mol Genet
Title: A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Volume: 23
Issue: 18
Pages: 4887-905
Publication
First Author: Garcia-Miralles M
Year: 2015
Journal: PLoS One
Title: No dopamine cell loss or changes in cytoskeleton function in transgenic mice expressing physiological levels of wild type or G2019S mutant LRRK2 and in human fibroblasts.
Volume: 10
Issue: 4
Pages: e0118947
Publication
First Author: Ho PW
Year: 2020
Journal: Autophagy
Title: Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Volume: 16
Issue: 2
Pages: 347-370
Publication  
First Author: Dwyer Z
Year: 2020
Journal: Neurobiol Aging
Title: Leucine-rich repeat kinase-2 (LRRK2) modulates microglial phenotype and dopaminergic neurodegeneration.
Volume: 91
Pages: 45-55
Publication  
First Author: Shutinoski B
Year: 2019
Journal: Sci Transl Med
Title: Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.
Volume: 11
Issue: 511
Publication  
First Author: Wu B
Year: 2016
Journal: Biomed Res Int
Title: Altered Expression of EPO Might Underlie Hepatic Hemangiomas in LRRK2 Knockout Mice.
Volume: 2016
Pages: 7681259
Publication
First Author: Han KA
Year: 2017
Journal: Hum Mol Genet
Title: Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.
Volume: 26
Issue: 1
Pages: 1-18
Publication  
First Author: Sitzia G
Year: 2022
Journal: Biomolecules
Title: Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.
Volume: 12
Issue: 11
Publication
First Author: Volpicelli-Daley LA
Year: 2016
Journal: J Neurosci
Title: G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
Volume: 36
Issue: 28
Pages: 7415-27
Publication
First Author: Lee JH
Year: 2019
Journal: Acta Neuropathol Commun
Title: Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.
Volume: 7
Issue: 1
Pages: 68
Publication  
First Author: Caesar M
Year: 2015
Journal: Neuroscience
Title: Changes in actin dynamics and F-actin structure both in synaptoneurosomes of LRRK2(R1441G) mutant mice and in primary human fibroblasts of LRRK2(G2019S) mutation carriers.
Volume: 284
Pages: 311-24
Publication
First Author: Li X
Year: 2007
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Volume: 103
Issue: 1
Pages: 238-47
Publication
First Author: Weindel CG
Year: 2022
Journal: Cell
Title: Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.
Volume: 185
Issue: 17
Pages: 3214-3231.e23
Publication
First Author: Daher JP
Year: 2012
Journal: Hum Mol Genet
Title: Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.
Volume: 21
Issue: 11
Pages: 2420-31
Publication
First Author: Caesar M
Year: 2014
Journal: Glia
Title: Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2.
Volume: 62
Issue: 7
Pages: 1075-92
Publication
First Author: Lee BD
Year: 2010
Journal: Nat Med
Title: Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Volume: 16
Issue: 9
Pages: 998-1000
Publication
First Author: Bardai FH
Year: 2018
Journal: PLoS Biol
Title: Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics.
Volume: 16
Issue: 12
Pages: e2006265
Publication
First Author: Wang L
Year: 2008
Journal: J Neurosci
Title: The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
Volume: 28
Issue: 13
Pages: 3384-91
Publication
First Author: Lin X
Year: 2009
Journal: Neuron
Title: Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Volume: 64
Issue: 6
Pages: 807-27
Publication
First Author: Liu G
Year: 2015
Journal: Hum Mol Genet
Title: Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.
Volume: 24
Issue: 18
Pages: 5299-312
Allele
Name: transgene insertion 1, Chenjian Li
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
HT Experiment
Series Id: GSE52584
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication    
First Author: Steger M
Year: 2017
Journal: Elife
Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Volume: 6
Publication  
First Author: Caesar M
Year: 2013
Journal: Neurobiol Dis
Title: Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration.
Volume: 54
Pages: 280-8
Publication      
First Author: Giaime E
Year: 2017
Journal: Neuron
Title: Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.
Publication
First Author: Ko HS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
Volume: 106
Issue: 8
Pages: 2897-902
Publication
First Author: Ho CC
Year: 2009
Journal: J Neurosci
Title: The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Volume: 29
Issue: 4
Pages: 1011-6
Publication
First Author: Piccoli G
Year: 2014
Journal: Mol Cell Biol
Title: Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Volume: 34
Issue: 12
Pages: 2147-61
Allele
Name: transgene insertion 32, Hung-Li Wang
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication  
First Author: Kubo M
Year: 2020
Journal: Int J Mol Sci
Title: Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.
Volume: 21
Issue: 5
Publication  
First Author: Maekawa T
Year: 2019
Journal: Front Neurosci
Title: Leucine-Rich Repeat Kinase 2 Is Associated With Activation of the Paraventricular Nucleus of the Hypothalamus and Stress-Related Gastrointestinal Dysmotility.
Volume: 13
Pages: 905
Publication
First Author: Maekawa T
Year: 2017
Journal: Dig Dis Sci
Title: LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut.
Volume: 62
Issue: 4
Pages: 903-912
Publication
First Author: Ito G
Year: 2016
Journal: Biochem J
Title: Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
Volume: 473
Issue: 17
Pages: 2671-85
Publication
First Author: Schulz C
Year: 2011
Journal: PLoS One
Title: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.
Volume: 6
Issue: 6
Pages: e20820
Publication
First Author: Yan J
Year: 2019
Journal: FASEB J
Title: Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2.
Volume: 33
Issue: 9
Pages: 9775-9784
Publication  
First Author: Hosseinzadeh Z
Year: 2017
Journal: Sci Rep
Title: Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells.
Volume: 7
Pages: 41117
Publication
First Author: Sarkar S
Year: 2021
Journal: Mol Neurodegener
Title: Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo.
Volume: 16
Issue: 1
Pages: 33
Publication
First Author: Xiong Y
Year: 2012
Journal: J Neurosci
Title: ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2.
Volume: 32
Issue: 11
Pages: 3877-86
Publication
First Author: Nichols RJ
Year: 2009
Journal: Biochem J
Title: Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Volume: 424
Issue: 1
Pages: 47-60
Publication
First Author: Rudenko IN
Year: 2012
Journal: Biochem J
Title: The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.
Volume: 446
Issue: 1
Pages: 99-111
Publication
First Author: Cho HJ
Year: 2013
Journal: Hum Mol Genet
Title: MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.
Volume: 22
Issue: 3
Pages: 608-20
Publication
First Author: Arbez N
Year: 2020
Journal: Hum Mol Genet
Title: G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.
Volume: 29
Issue: 4
Pages: 580-590
Publication
First Author: Zhang Q
Year: 2015
Journal: Nat Immunol
Title: Commensal bacteria direct selective cargo sorting to promote symbiosis.
Volume: 16
Issue: 9
Pages: 918-26
Publication
First Author: Civiero L
Year: 2015
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Volume: 135
Issue: 6
Pages: 1242-56
Publication
First Author: Cho HJ
Year: 2014
Journal: EMBO J
Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
Volume: 33
Issue: 20
Pages: 2314-31
Publication
First Author: Cui J
Year: 2011
Journal: Biosci Rep
Title: Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.
Volume: 31
Issue: 5
Pages: 429-37
Publication
First Author: Papkovskaia TD
Year: 2012
Journal: Hum Mol Genet
Title: G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.
Volume: 21
Issue: 19
Pages: 4201-13
Publication
First Author: Zechel S
Year: 2010
Journal: Int J Dev Neurosci
Title: Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.
Volume: 28
Issue: 5
Pages: 391-9
Publication
First Author: Chen X
Year: 2020
Journal: Mol Neurodegener
Title: Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
Volume: 15
Issue: 1
Pages: 12
Publication
First Author: Wandu WS
Year: 2015
Journal: PLoS One
Title: Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.
Volume: 10
Issue: 6
Pages: e0128906
Publication
First Author: Yan J
Year: 2015
Journal: FASEB J
Title: Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells.
Volume: 29
Issue: 5
Pages: 1701-10
Publication
First Author: Civiero L
Year: 2012
Journal: PLoS One
Title: Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Volume: 7
Issue: 8
Pages: e43472
Publication
First Author: Liu M
Year: 2010
Journal: Biochemistry
Title: Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.
Volume: 49
Issue: 9
Pages: 2008-17
Publication
First Author: Scheiblich H
Year: 2021
Journal: Cell
Title: Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Volume: 184
Issue: 20
Pages: 5089-5106.e21
Publication
First Author: Beilina A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.
Volume: 111
Issue: 7
Pages: 2626-31
Publication
First Author: Tong Y
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Volume: 107
Issue: 21
Pages: 9879-84
Publication
First Author: Gillardon F
Year: 2009
Journal: J Neurochem
Title: Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?
Volume: 110
Issue: 5
Pages: 1514-22
Publication
First Author: Higashi S
Year: 2007
Journal: J Neurochem
Title: Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Volume: 100
Issue: 2
Pages: 368-81
Publication
First Author: Mir R
Year: 2018
Journal: Biochem J
Title: The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Volume: 475
Issue: 11
Pages: 1861-1883