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Search results 1 to 5 out of 5 for Grip1

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: This entry represent GRIP1. The interaction between GRIP1 and 14-3-3 proteins is essential for the function of GRIP1 as an adaptor protein in dendritic cargo trafficking [].Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) []. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [, ]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 [].
Protein Domain
Type: Domain
Description: Calcium-binding and coiled-coil domain-containing protein 1 (Calcoco1) from Mus musculus () binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 (), and thus enhances transcriptional activation by a number of nuclear receptors. Calcoco1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [].
Protein Domain
Type: Family
Description: Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) []. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [, ]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 [].This entry includes glutamate receptor-interacting protein 1/2 (GRIP1/2).
Protein Domain
Type: Family
Description: This entry represent GRIP2. In mice GRIP2 functions downstream of Notch3/RBP-Jkappa to regulate myogenic tone in the brain arteries []. In Xenopus GRIP2 is involved in primordial germ cell development and migration []. Glutamate receptor-interacting proteins (GRIPs) are multi-PDZ domain scaffolding proteins required for dendrite development. There are two members of the GRIP family: GRIP1 and GRIP2/ABP (AMPA receptor binding protein) []. GRIPs regulate AMPAR receptor trafficking and neuronal plasticity [, ]. They also bind various receptor and signalling proteins, such as EphB receptors, ephrinB ligands, the proteoglycan NG2, the Fraser syndrome protein Fras1, and matrix metalloproteinase 5 [].
Protein Domain
Type: Family
Description: The microtubule organizing centres (MTOCs) of eukaryotic cells are the sites of nucleation of microtubules, and are known as the centrosome in animal cells and the spindle pole body in yeast. Gamma-tubulin, which is 30% identical to alpha and beta tubulins that form microtubules, appears to be a key protein involved in nucleation of microtubules.Gamma tubulin can assemble into complexes of various sizes with members of the GCP family. In budding yeast, the gamma tubulin-containing small complex (gammaTuSC) contains gamma tubulin, GCP2 and GCP3 (also known as Spc97 and Spc98). In Drosophila and vertebrates, gamma tubulin forms much larger assemblies, termed gamma-tubulin ring complexes (gammaTuRCs), with gamma tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6. The purified gammaTuSC and gammaTuRC complexes exhibit a 'lock washer' shape []. However, the purified gammaTuSC has been shown to have a much lower microtubule-nucleating activity than intact gammaTuRC []. Several models have been proposed to explain their assembly and nucleation mechanism []. This entry represents the GCP family, whose members include GCP2/3/4/5/6 and Spc97/98 []. They contain the GRIP1 and GRIP2 motifs, which are predicted to participate in protein-protein interactions []. They are gamma tubulin binding proteins that have similar protein structures [].