The TGFBI (transforming growth factor-beta-induced protein ig-h3) gene was originally identified as a gene induced by transforming growth factor-beta stimulation in adenocarcinoma cells. Later, it was found to interact with a number of extracellular matrix (ECM) proteins, including fibronectin, biglycan, decorin, and several types of collagen. It also acts as a ligand for several integrins, including alhpa3beta1, alphavbeta5, alphavbeta3, and alphambeta2. It may function as a secreted factor involved in cell adhesion, proliferation, and migration [].Mutations in the TGFBI gene cause several types of corneal dystrophy [, , , , ].
