Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1840623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_06 |
|
Specimen Label: |
euxassay_004414_06 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1840623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_07 |
|
Specimen Label: |
euxassay_004414_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1840623 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_08 |
|
Specimen Label: |
euxassay_004414_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_04 |
|
Specimen Label: |
euxassay_004414_04 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_05 |
|
Specimen Label: |
euxassay_004414_05 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_06 |
|
Specimen Label: |
euxassay_004414_06 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_07 |
|
Specimen Label: |
euxassay_004414_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_08 |
|
Specimen Label: |
euxassay_004414_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_17 |
|
Specimen Label: |
euxassay_004414_17 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_18 |
|
Specimen Label: |
euxassay_004414_18 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_19 |
|
Specimen Label: |
euxassay_004414_19 |
Detected: |
true |
Specimen Num: |
19 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_20 |
|
Specimen Label: |
euxassay_004414_20 |
Detected: |
true |
Specimen Num: |
20 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_21 |
|
Specimen Label: |
euxassay_004414_21 |
Detected: |
true |
Specimen Num: |
21 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679723 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_22 |
|
Specimen Label: |
euxassay_004414_22 |
Detected: |
true |
Specimen Num: |
22 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_07 |
|
Specimen Label: |
euxassay_004414_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1756923 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_18 |
|
Specimen Label: |
euxassay_004414_18 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5659764 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3565128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5659944 |
Age: |
postnatal |
Image: |
7A |
|
Specimen Label: |
7A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5659764 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3565128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5659944 |
Age: |
postnatal |
Image: |
7B |
Note: |
Expression levels are reduced in the mutant. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_07 |
|
Specimen Label: |
euxassay_004414_07 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_08 |
|
Specimen Label: |
euxassay_004414_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_17 |
|
Specimen Label: |
euxassay_004414_17 |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_18 |
|
Specimen Label: |
euxassay_004414_18 |
Detected: |
true |
Specimen Num: |
18 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1755823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_08 |
Note: |
facial motor nucleus |
Specimen Label: |
euxassay_004414_08 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1755823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_09 |
Note: |
facial motor nucleus |
Specimen Label: |
euxassay_004414_09 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1755823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_15 |
Note: |
facial motor nucleus |
Specimen Label: |
euxassay_004414_15 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1399430 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1755823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827579 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_004414_16 |
Note: |
facial motor nucleus |
Specimen Label: |
euxassay_004414_16 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bubier JA |
Year: |
2020 |
Journal: |
Front Neurosci |
Title: |
Discovery of a Role for Rab3b in Habituation and Cocaine Induced Locomotor Activation in Mice Using Heterogeneous Functional Genomic Analysis. |
Volume: |
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Pages: |
721 |
|
•
•
•
•
•
|
Publication |
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Yu Z |
Year: |
2022 |
Journal: |
Exp Eye Res |
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Cathepsin S is a novel target for age-related dry eye. |
Volume: |
214 |
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Pages: |
108895 |
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•
•
•
•
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Publication |
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J Biol Chem |
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•
•
•
•
•
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Publication |
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Leenders AG |
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2001 |
Journal: |
Mol Biol Cell |
Title: |
Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. |
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10 |
Pages: |
3095-102 |
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•
•
•
•
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Publication |
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Matsumoto M |
Year: |
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Journal: |
Proc Natl Acad Sci U S A |
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Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. |
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•
•
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Publication |
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Journal: |
J Biol Chem |
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Isoprenylcysteine carboxyl methyltransferase deficiency in mice. |
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2021 |
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Sci Rep |
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Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function. |
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J Biol Chem |
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Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |
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2007 |
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Cell Metab |
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BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. |
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Proc Natl Acad Sci U S A |
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Hoffman BG |
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Genome Biol |
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Identification of transcripts with enriched expression in the developing and adult pancreas. |
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Cell |
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A mitochondrial protein compendium elucidates complex I disease biology. |
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Mouse Genome Informatics Scientific Curators |
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Data Curation Using Mouse Genome Assembly |
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Velocigene |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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International Mouse Strain Resource |
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Database Download |
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MGI download of germline transmission data for alleles from IMSR strain data |
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Wellcome Trust Sanger Institute |
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2010 |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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GOA curators |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Mouse Genome Informatics Scientific Curators |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Carninci P |
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Science |
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The transcriptional landscape of the mammalian genome. |
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Nature |
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Zambrowicz BP |
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2003 |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Issue: |
24 |
Pages: |
14109-14 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Nishio H |
Year: |
1999 |
Journal: |
Biochim Biophys Acta |
Title: |
Molecular cloning of cDNA encoding human Rab3D whose expression is upregulated with myeloid differentiation. |
Volume: |
1444 |
Issue: |
2 |
Pages: |
283-90 |
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•
•
•
•
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Publication |
First Author: |
Millar AL |
Year: |
2002 |
Journal: |
Histol Histopathol |
Title: |
Rab3D: a regulator of exocytosis in non-neuronal cells. |
Volume: |
17 |
Issue: |
3 |
Pages: |
929-36 |
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•
•
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•
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Publication |
First Author: |
Efimova EV |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
IG20, in contrast to DENN-SV, (MADD splice variants) suppresses tumor cell survival, and enhances their susceptibility to apoptosis and cancer drugs. |
Volume: |
23 |
Issue: |
5 |
Pages: |
1076-87 |
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•
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Publication |
First Author: |
Schievella AR |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. |
Volume: |
272 |
Issue: |
18 |
Pages: |
12069-75 |
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•
•
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•
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Publication |
First Author: |
Iwasaki K |
Year: |
1997 |
Journal: |
Neuron |
Title: |
aex-3 encodes a novel regulator of presynaptic activity in C. elegans. |
Volume: |
18 |
Issue: |
4 |
Pages: |
613-22 |
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Protein Domain |
Type: |
Family |
Description: |
MAP kinase-activating death domain protein (MADD) regulates cell proliferation, survival and death through alternative mRNA splicing. Different isoforms have different effects: isoform 5 increases cell proliferation whereas isoform 2 decreases it; isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant []. MADD activates RAB3A, RAB3C and RAB3D by converting them from GDP-bound inactive forms to GTP-bound active forms []. MADD is a component of the TNFRSF1A signaling complex, linking the type 1 tumor necrosis factor receptor TNFRSF1A with MAP kinase activation []. MADD contains a tripartite DENN domain. In the nematode Caenorhabditis elegans, MADD is also known as regulator of presynaptic activity aex-3 []. |
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Protein Domain |
Type: |
Family |
Description: |
The Rab3 subfamily contains Rab3A, Rab3B, Rab3C, and Rab3D. All four isoforms were found in mouse brain and endocrine tissues, with varying levels of expression. Rab3A, Rab3B, and Rab3C localized to synaptic and secretory vesicles; Rab3D was expressed at high levels only in adipose tissue, exocrine glands, and the endocrine pituitary, where it is localized to cytoplasmic secretory granules []. Rab3 appears to control Ca2+-regulated exocytosis. The appropriate GDP/GTP exchange cycle of Rab3A is required for Ca2+-regulated exocytosis to occur, and interaction of the GTP-bound form of Rab3A with effector molecule(s) is widely believed to be essential for this process []. |
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Publication |
First Author: |
Hou Y |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. |
Volume: |
471 |
Issue: |
4 |
Pages: |
610-5 |
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•
•
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Publication |
First Author: |
Chiang L |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. |
Volume: |
301 |
Issue: |
2 |
Pages: |
C507-21 |
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•
•
•
•
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Publication |
First Author: |
Sons MS |
Year: |
2006 |
Journal: |
Brain Res |
Title: |
Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse. |
Volume: |
1089 |
Issue: |
1 |
Pages: |
126-34 |
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•
•
•
•
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Publication |
First Author: |
Hou Y |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e0125596 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
227
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
225
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
227
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
219
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
225
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshimura S |
Year: |
2010 |
Journal: |
J Cell Biol |
Title: |
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. |
Volume: |
191 |
Issue: |
2 |
Pages: |
367-81 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1577
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1627
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1602
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1574
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1577
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1562
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1632
|
Fragment?: |
false |
|
•
•
•
•
•
|