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Search results 601 to 700 out of 831 for Lrp2

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Type Details Score
Publication
28527294 | J:243840
First Author: Gerl K
Year: 2017
Journal: Am J Pathol
Title: Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
Volume: 187
Issue: 7
Pages: 1496-1511
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Publication
23592779 | J:199615
First Author: Cases O
Year: 2013
Journal: J Biol Chem
Title: Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Volume: 288
Issue: 23
Pages: 16655-70
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Publication
11208732 | J:66998
First Author: Lammert F
Year: 2001
Journal: Gastroenterology
Title: Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.
Volume: 120
Issue: 1
Pages: 221-38
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
23382219 | J:194542
First Author: Ghai R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Volume: 110
Issue: 8
Pages: E643-52
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Publication
25807483 | J:222159
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
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Publication
- | J:175213
     
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
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Publication
8827514 | J:34178
First Author: Welch CL
Year: 1996
Journal: J Lipid Res
Title: Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Volume: 37
Issue: 7
Pages: 1406-21
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
19521566 | J:177549
First Author: Willnow T
Year: 2005
Journal: Organogenesis
Title: The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Volume: 2
Issue: 2
Pages: 42-7
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Protein Coding Gene
MGP_CAROLIEiJ_G0031027 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033562 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034078 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033250 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021495 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032141 | -
Type: protein_coding_gene
Organism: Mus spretus
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Allele
Lrp2bp<tm2a(KOMP)Wtsi> | MGI:5294971
Name: Lrp2 binding protein; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Lrp2bp<tm2e(KOMP)Wtsi> | MGI:5296113
Name: Lrp2 binding protein; targeted mutation 2e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Lrp2<em2Smoc> | MGI:7290870
Name: low density lipoprotein receptor-related protein 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:6189081
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360356
Pattern: Regionally restricted
Stage: TS06
Assay Id: MGI:6189098
Age: embryonic day 4.5
Image: 5C
Note: Authors report co-expression with Lrp2 on the apical surface of the primitive endoderm epithelium at E4.5.
Specimen Label: 5C
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6189081
Assay Type: Immunohistochemistry
Annotation Date: 2018-07-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160516
Pattern: Regionally restricted
Stage: TS06
Assay Id: MGI:6189098
Age: embryonic day 4.5
Image: 5B
Note: Authors report co-expression with Lrp2 on the apical surface of the primitive endoderm epithelium at E4.5.
Specimen Label: 5B
Detected: true
Specimen Num: 2
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Allele
Lrp2<tm1.1(cre/ERT2)Bara> | MGI:7279146
Name: low density lipoprotein receptor-related protein 2; targeted mutation 1.1, Jonathan Barasch
Allele Type: Targeted
Attribute String: Inducible, Recombinase
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Allele
Lrp2<em1Smoc> | MGI:7290869
Name: low density lipoprotein receptor-related protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Lrp2<tm2(EGFP/cre)Tew> | MGI:5314898
Name: low density lipoprotein receptor-related protein 2; targeted mutation 2, Thomas E Willnow
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Tg(Lrp2-EGFP)FM334Gsat | MGI:4847207
Name: transgene insertion FM334, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Lrp2<tm3Tew> | MGI:5426261
Name: low density lipoprotein receptor-related protein 2; targeted mutation 3, Thomas E Willnow
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Strain
MGI:5003991 | STOCK Tg(Lrp2-EGFP)FM334Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Lrp2/Lrp2<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lrp2/Lrp2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
30814516 | J:273907
First Author: Nandadasa S
Year: 2019
Journal: Nat Commun
Title: Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.
Volume: 10
Issue: 1
Pages: 953
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Publication
32332780 | J:292220
First Author: Seo JA
Year: 2020
Journal: Nat Commun
Title: Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.
Volume: 11
Issue: 1
Pages: 2024
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Publication
30590522 | J:275641
First Author: Festa BP
Year: 2019
Journal: Hum Mol Genet
Title: OCRL deficiency impairs endolysosomal function in a humanized mouse model for Lowe syndrome and Dent disease.
Volume: 28
Issue: 12
Pages: 1931-1946
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Publication
31483289 | J:280893
First Author: Liu Y
Year: 2019
Journal: J Clin Invest
Title: Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice.
Volume: 129
Issue: 10
Pages: 4261-4275
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Publication
27554085 | J:316650
First Author: Nasrallah R
Year: 2016
Journal: Blood
Title: Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes.
Volume: 128
Issue: 15
Pages: 1928-1939
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Publication
7979249 | -
 
First Author: Krieger M
Year: 1994
Journal: Annu Rev Biochem
Title: Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).
Volume: 63
Pages: 601-37
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Publication
7548065 | -
First Author: Bieri S
Year: 1995
Journal: Biochemistry
Title: Disulfide bridges of a cysteine-rich repeat of the LDL receptor ligand-binding domain.
Volume: 34
Issue: 40
Pages: 13059-65
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Publication
3283935 | -
First Author: Mahley RW
Year: 1988
Journal: Science
Title: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
Volume: 240
Issue: 4852
Pages: 622-30
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Protein Domain
IPR023415 | LDLR_class-A_CS
Type: Conserved_site
Description: Low-density lipoprotein (LDL) receptors are the major cholesterol-carrying lipoproteins of plasma. Seven successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein []. Similar domains have been found (see references in []) in other extracellular and membrane proteins which are listed below: Vertebrate very low density lipoprotein (VLDL) receptor, which binds and transports VLDL. Its extracellular domain is composed of 8 LDLRA domains, 3 EGF-like domains and 6 LDL-receptor class B domains (LDLRB). Vertebrate low-density lipoprotein receptor-related protein 1 (LRP1) (reviewed in []), which may act as a receptor for the endocytosis of extracellular ligands. LRP1 contains 31 LDLRA domains and 22 EGF-like domains. Vertebrate low-density lipoprotein receptor-related protein 2 (LRP2) (also known as gp330 or megalin). LRP2 contains 36 LDLRA domains and 17 EGF-like domains. A LRP-homologue from Caenorhabditis elegans, which contains 35 LDLRA domains and 17 EGF-like domains. Drosophila putative vitellogenin receptor, with 13 copies of LDLRA domains and 17 EGF-like repeats. Complement factor I, which is responsible for cleaving the alpha-chains of C4b and C3b. It consists of a FIMAC domain (Factor I/MAC proteins C6/C7), a scavenger receptor-like domain, 2 copies of LDLRA and a C-terminal serine protease domain. Complement components C6, C7, C8 and C9. They contain each one LDLRA domain. Perlecan, a large multidomain basement membrane heparan sulphate proteoglycan composed of 4 LDLRA domains, 3 LamB domains, 12 laminin EGF- like domains, 14-21 IG-like domains, 3 LamG domains, and 4 EGF-like domains. A similar but shorter proteoglycan (UNC52) is found in Caenorhabditis elegans which has 3 repeats of LDLRA. Invertebrate giant extracellular hemoglobin linker chains, which allow heme-containing chains to construct giant hemoglobin (1 LDLRA domain). G-protein coupled receptor Grl101 of the snail Lymnaea stagnalis, which might directly transduce signals carried by large extracellular proteins. Vertebrate enterokinase (EC 3.4.21.9), a type II membrane protein of the intestinal brush border, which activates trypsinogen. It consists at least of a catalytic light chain and a multidomain heavy chain which has 2 LDLRA, a MAM domain (see ), a SRCR domain (see ) and a CUB domain (see ).Human autosomal dominant polycystic kidney disease protein 1 (PKD1), which is involved in adhesive protein-protein and protein-carbohydrate interactions. The potential calcium-binding site of its single LDLRA domain is missing. Vertebrate integral membrane protein DGCR2/IDD, a potential adhesion receptor with 1 LDLRA domain, a C-type lectin and a VWFC domain (see ).Drosophila serine protease nudel (EC 3.4.21.-), which is involved in the induction of dorsoventral polarity of the embryo. It has 11 LDLRA domains, 3 of which miss the first disulphide bond (C1-C3). Avian subgroup A rous sarcoma virus receptor (1 copy of LDLRA). Bovine Sco-spondin, which is secreted by the subcommissural organ in embryos and is involved in the modulation of neuronal aggregation. It contains at least 2 EGF-like domains and 3 LDLRA domains. The LDL-receptor class A domain contains 6 disulphide-bound cysteines []and a highly conserved cluster of negatively charged amino acids, of which many are clustered on one face of the module []. A schematic representation of this domain is shown here: +---------------------+ +--------------------------------+| | | |-CxxxxxxxxxxxxCxxxxxxxxCxxxxxxxxCxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxC-|*******************************************| |+----------------------------+'C': conserved cysteine involved in a disulphide bond.'x': any residue.'*': position of the pattern.In LDL-receptors the class A domains form the binding site for LDL []and calcium. The acidic residues between the fourth and sixth cysteines are important for high-affinity binding of positively charged sequences in LDLR's ligands []. The repeat has been shown []to consist of a β-hairpin structure followed by a series of β-turns. The binding of calcium seems to induce no significant conformational change.
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Protein
Q9Z1P5
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Protein
A2AR95
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
Q8BWJ4
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
J3QNN2
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
A0A068BES0
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: false
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Protein
F6UAC8
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
S4R2B5
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
•
•
•
•
•
Protein
E9Q643
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
•
•
•
•
•
Protein
B7ZND2
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
•
•
•
•
•
Protein
A0A068BD29
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
•
•
•
•
•
Protein
A0A087WPW4
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
•
•
•
•
•
Protein
Q6P220
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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