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Search results 401 to 432 out of 432 for Nob1

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0.018s

Type

Details

Score

Genotype

Symbol:	Nidds/? Tbc1d1/?
Background:	involves: NZO/HlBom * SJL/NBom
Zygosity:	cx
Has Mutant Allele:	true

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Genotype

Symbol:	Nidds/Nidds
Background:	involves: NZO/HlBom * SJL/NBom
Zygosity:	ht
Has Mutant Allele:	true

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Protein Coding Gene

MGI:1889508 | Tbc1d1

Type:	protein_coding_gene
Organism:	mouse, laboratory

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Publication

12502737 | -

First Author:	Tone Y
Year:	2002
Journal:	Genes Dev
Title:	Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae.
Volume:	16
Issue:	24
Pages:	3142-57

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Publication

12736301 | -

First Author:	Senapin S
Year:	2003
Journal:	Nucleic Acids Res
Title:	RRP20, a component of the 90S preribosome, is required for pre-18S rRNA processing in Saccharomyces cerevisiae.
Volume:	31
Issue:	10
Pages:	2524-33

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Publication

15037774 | -

First Author:	Vanrobays E
Year:	2004
Journal:	RNA
Title:	Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.
Volume:	10
Issue:	4
Pages:	645-56

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Protein Domain

IPR039912 | PNO1-like

Type:

Family

Description:

Pre-rRNA-processing protein PNO1 is also known as Partner of NOB1 and ribosomal RNA-processing protein 20. NOB1 is a nuclear protein that forms a complex with the 19S regulatory particle of the 26S proteasome and PNO1, acting as a chaperone to join the 20S proteasome with the 19S regulatory particle. The NOB1 complex is then degraded by the mature 26S proteasome []. PNO1 is also a component of the pre-ribosomal particle, and strains lacking PNO1 are defective in ribosomal RNA processing []. PNO1 remains a component of the SSU RRP complex, in which pre-40S subunits are left associated with a limited set of proteins []. PNO1 contains a K Homology domain.

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Publication

22751017 | -

First Author:	Lebaron S
Year:	2012
Journal:	Nat Struct Mol Biol
Title:	Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits.
Volume:	19
Issue:	8
Pages:	744-53

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Protein Domain

IPR017117 | Nob1_euk

Type:	Family
Description:	Budding yeast Nob1 is involved in proteasomal and 40S ribosomal subunit biogenesis. It is required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA [, , ].

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Protein Domain

IPR033411 | Ribonuclease_PIN

Type:

Domain

Description:

This is a PIN domain found in eukaryotic ribonuclease Nob1 and archaeal ribonuclease VapC1 []. RNA-binding protein NOB1 has a nuclear location []and contains a PIN domain and binds a single zinc ion. Budding yeast Nob1 is involved in proteasomal and 40S ribosomal subunit biogenesis []. It is also required for maturation of the small subunit ribosomal RNA by catalyzing cleavage at site D after export of the preribosomal subunit into the cytoplasm. Nob1 is also found in archaea, where it is manganese-dependent and also processes RNA-substrates []. This domain can also be found in VapC1, which is a toxic component and a ribonuclease of a toxin-antitoxin (TA) module [].PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation []. PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA decay []and in processing of 18S ribosomal RNA []. In prokaryotes, they are the toxic components of toxin-antitoxin (TA) systems, their toxicity arising by virtue of their ribonuclease activity. The PIN domain TA systems are now called VapBC TAs(virulence associated proteins), where VapB is the inhibitor and VapC, the PIN-domain ribonuclease toxin [].

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Publication

10844592 | J:63377

First Author:	Abidari JM
Year:	2000
Journal:	Kidney Int
Title:	Identification of novel genes expressed during metanephric induction through single-cell library screening.
Volume:	57
Issue:	6
Pages:	2221-8

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Publication

18931681 | J:143559

First Author:	Chadt A
Year:	2008
Journal:	Nat Genet
Title:	Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.
Volume:	40
Issue:	11
Pages:	1354-9

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Publication

17053788 | -

First Author:	Glavan F
Year:	2006
Journal:	EMBO J
Title:	Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Volume:	25
Issue:	21
Pages:	5117-25

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Publication

24990943 | -

First Author:	Zheng S
Year:	2014
Journal:	J Biol Chem
Title:	Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast.
Volume:	289
Issue:	33
Pages:	22692-703

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Publication

29263326 | -

First Author:	Sturm M
Year:	2017
Journal:	Nat Commun
Title:	Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly.
Volume:	8
Issue:	1
Pages:	2213

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Protein Domain

IPR041174 | KH_8

Type:

Domain

Description:

This entry represents the first K homology domain (KH1) in the KRR1 and Dim2 (Pno1) proteins.Krr1 and Dim2 are structurally related ribosomal assembly factors, present on the 90S pre-ribosome []. They both belong to the family of RNA binding domains that contain K homology (KH) domains. Dim2 and Krr1 each contain two sequential KH domains (KH1 and KH2), but the N and C-terminal extensions differ between the two proteins []. The two KH domains are evident in the structure of KKr1 from Saccharomyces Cerevisiae [].The KH1 domains in Krr1 and Dim2 lack the typical GXXG RNA binding motif and are involved, instead, in protein-protein interactions. The KH1 domain in Krr1 interacts with the nucleolar assembly factor Kri1 and the KH1 domain of Dim2 interacts with the endonuclease Nob1 [].

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Publication

11151768 | J:66744

First Author:	Kluge R
Year:	2000
Journal:	Diabetologia
Title:	Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice.
Volume:	43
Issue:	12
Pages:	1565-72

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Protein

Q9CPS7

Organism:	Mus musculus/domesticus
Length:	248
Fragment?:	false

•

Publication

12727230 | J:83735

First Author:	Giesen K
Year:	2003
Journal:	Biochem Biophys Res Commun
Title:	Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5.
Volume:	304
Issue:	4
Pages:	812-7

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Publication

21036780 | -

First Author:	Arcus VL
Year:	2011
Journal:	Protein Eng Des Sel
Title:	The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array.
Volume:	24
Issue:	1-2
Pages:	33-40

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Protein

Q8BGA5

Organism:	Mus musculus/domesticus
Length:	380
Fragment?:	false

•

Protein

G3UZA0

Organism:	Mus musculus/domesticus
Length:	323
Fragment?:	false

•

Publication

19521500 | J:149737

First Author:	Sansom SN
Year:	2009
Journal:	PLoS Genet
Title:	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume:	5
Issue:	6
Pages:	e1000511

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Publication

16033648 | J:103446

First Author:	McKee AE
Year:	2005
Journal:	BMC Dev Biol
Title:	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume:	5

Pages:	14

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Publication

- | J:157064

First Author:	University of California, Davis
Year:	2010
Journal:	MGI Direct Data Submission
Title:	Alleles produced for the KOMP project by the University of California, Davis

•

Publication

10725249 | J:60984

First Author:	Ko MS
Year:	2000
Journal:	Development
Title:	Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume:	127
Issue:	8
Pages:	1737-49

•

Publication

- | J:73796

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Function or Process or Component Unknown following Literature Review

•

Publication

- | J:342605

First Author:	GOA curators
Year:	2016

Title:	Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

•

Publication

- | J:342587

First Author:	AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year:	2011

Title:	Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

- | J:68900

First Author:	The Jackson Laboratory Mouse Radiation Hybrid Database
Year:	2004
Journal:	Database Release
Title:	Mouse T31 Radiation Hybrid Data Load

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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