SH3RF1 (or POSH) is a scaffold protein that function as an E3 ubiquitin-protein ligase. It contains an N-terminal RING finger domain and four SH3 domains. It belongs to the POSH family, which includes POSH1, POSH2 and POSH3 [].
SH3RF1 (or POSH) and SH3RF3 (or POSH2) are scaffold proteins that function as E3 ubiquitin-protein ligases. They contain an N-terminal RING finger domain and four SH3 domains []. This entry represents the fourth SH3 domain, located at the C terminus of SH3RF1 and SH3RF3, and similar domains. SH3RF1 plays a role in calcium homeostasis through the control of the ubiquitin domain protein Herp []. It may also have a role in regulating death receptor mediated and JNK mediated apoptosis []. SH3RF3 interacts with p21-activated kinase 2 (PAK2) and GTP-loaded Rac1 [].
This entry represents the third SH3 domain, located in the middle, of SH3RF3.SH3RF3 (also known as POSH2) is a scaffold protein with E3 ubiquitin-protein ligase activity []. It was identified in the screen for interacting partners of p21-activated kinase 2 (PAK2). It may play a role in regulating JNK mediated apoptosis in certain conditions []. It also interacts with GTP-loaded Rac1 []. SH3RF3 is highly homologous to SH3RF1; it also contains an N-terminal RING finger domain and four SH3 domains.
