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Search results 701 to 800 out of 834 for Cd80

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Type Details Score
Publication
18931363 | J:143565
First Author: Banerjee P
Year: 2008
Journal: Int Immunol
Title: Porin-incorporated liposome induces Toll-like receptors 2- and 6-dependent maturation and type 1 response of dendritic cell.
Volume: 20
Issue: 12
Pages: 1551-63
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Publication
27288425 | J:239854
First Author: Wang F
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Contribution of programmed cell death receptor (PD)-1 to Kupffer cell dysfunction in murine polymicrobial sepsis.
Volume: 311
Issue: 2
Pages: G237-45
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Publication
28522600 | J:247684
First Author: Cao Y
Year: 2017
Journal: J Leukoc Biol
Title: Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response.
Volume: 102
Issue: 3
Pages: 575-587
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Publication
34301886 | J:322452
 
First Author: Tekguc M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells.
Volume: 118
Issue: 30
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Publication
34281386 | J:312990
First Author: Matundan HH
Year: 2021
Journal: mBio
Title: Absence of CD28-CTLA4-PD-L1 Costimulatory Molecules Reduces Herpes Simplex Virus 1 Reactivation.
Volume: 12
Issue: 4
Pages: e0117621
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Protein Domain
IPR008096 | CTLA4
Type: Family
Description: T cell-dependent immune processes require cell-surface interactions thatmediate the initiation, modulation and the ultimate course of the response.The specificity of T cell recognition is determined by the engagement of theT cell receptor (TCR) on T cells with cognate peptide-MHC complexes presented by antigen presenting cells (APCs). Additional signals arerequired to sustain and enhance T cell activity, the most important of whichis provided by the engagement of CD28 on T cells with its ligands B7-1(CD80) and B7-2 (CD86). By contrast, the interaction of B7 isoformswith cytotoxic T lymphocyte-associated molecule-4 CTLA-4, a CD28 homologue receptor on T cells (31% identity), provides inhibitory signals requiredfor down-regulation of the response, while it may also prevent T cell activation by weak TCR signals[, , , , ].Unlike CD28, which is not expressed on resting T cells, CTLA-4 is not detected on the cell surface until 24 hours after activation. In fact, Tcell activation leads to both increased CTLA4 gene expression andtrafficking of CTLA4 protein to the cell surface. In addition, CTLA-4exhibits an affinity for the B7 isoforms that is 10 to 100 times that forCD28. Covalent dimerisation of CTLA4 is required for its high bindingavidity, but each monomeric subunit also contains a binding site for CD80and CD86. It is likely that CTLA-4 directly competes with CD28 for bindingB7 and also directs the assembly of inhibitory signalling complexes thatlead to quiescence or anergy. Thus the balance between the opposing signals elicited by CD28 and CTLA-4 is central to the regulation of T cellresponsiveness and homeostasis. One mechanism by which CTLA-4 may performthis function is by regulating cell-cycle progression; by contrast with CD28, which down-regulates the cell-cycle inhibitor p27kip1, CTLA-4 prevents this degradation[, , ].Sequence comparison between human CTLA-4 and CD28 proteins suggests they arehomologous, with the highest of degree of similarity being in the juxta-membrane and cytoplasmic regions. In addition, the cytoplasmic domainsof human and murine CTLA-4 are identical, suggesting that this region hasimportant functional properties [].Typically, activation of T cells by TCR-engaging peptide-MHC is dramatically enhanced by interaction of the CD28 co-stimulatory receptor with its ligands CD80 (B7-1) and CD86 (B7-2) on the APC surface. Interestingly, CTLA-4 is transported from intracellular stores toward the region of the cell surface receiving activation signals. This suggests that binding of CD28 to its ligand may occur primarily at the centre of the mature immunological synapse, and that CTLA-4 may be transported to this site under certain circumstancesto block or reverse this effect.
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Protein
Q9DCF1
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
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Protein
A0A1N9MYB8
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
A0A1L1SU51
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein
Q3U4J4
Organism: Mus musculus/domesticus
Length: 392  
Fragment?: false
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Protein
A0A1L1SQN0
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
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Protein
Q571G9
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
A0A1L1SRQ1
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
A0A1L1SVA2
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Publication
16200068 | J:112600
First Author: Park H
Year: 2005
Journal: Nat Immunol
Title: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
Volume: 6
Issue: 11
Pages: 1133-41
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Publication
22144572 | J:315782
First Author: Shimizu K
Year: 2011
Journal: Circulation
Title: Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection.
Volume: 124
Issue: 25
Pages: 2920-32
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Publication
30761150 | J:284474
 
First Author: Rip J
Year: 2019
Journal: Front Immunol
Title: Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease.
Volume: 10
Pages: 95
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Publication
29543531 | J:275031
First Author: Schmitz C
Year: 2018
Journal: FASEB J
Title: Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.
Volume: 32
Issue: 8
Pages: 4428-4443
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Publication
11052947 | J:65436
First Author: Ostrov DA
Year: 2000
Journal: Science
Title: Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Volume: 290
Issue: 5492
Pages: 816-9
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Publication
1714933 | -
First Author: Linsley PS
Year: 1991
Journal: J Exp Med
Title: CTLA-4 is a second receptor for the B cell activation antigen B7.
Volume: 174
Issue: 3
Pages: 561-9
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Publication
11841692 | -
First Author: Wang XB
Year: 2002
Journal: Scand J Immunol
Title: Expression of CTLA-4 by human monocytes.
Volume: 55
Issue: 1
Pages: 53-60
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Protein
P35329
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
Q9WUL5
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
P20917
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
Q6XJV6
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
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Protein
Q61490
Organism: Mus musculus/domesticus
Length: 583  
Fragment?: false
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Protein
Q9R069
Organism: Mus musculus/domesticus
Length: 622  
Fragment?: false
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Protein
Q3ZB61
Organism: Mus musculus/domesticus
Length: 609  
Fragment?: true
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Protein
A0A1L1SSS3
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: true
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Protein
Q8BGB4
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q8BJ95
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: false
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Protein
Q3U304
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
E9Q4G8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
A0A087WR96
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
Q3TAX0
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein
Q3T9T5
Organism: Mus musculus/domesticus
Length: 932  
Fragment?: true
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Protein
E9Q3Q6
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q3TAA6
Organism: Mus musculus/domesticus
Length: 459  
Fragment?: true
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Protein
F1ABS2
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
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Protein
F6QH25
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: true
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Protein
H3BJX3
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
A0A171EBL3
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
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Protein
Q3T1F6
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q99K86
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
Q3ZB62
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
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Protein
Q54AJ5
Organism: Mus musculus/domesticus
Length: 583  
Fragment?: false
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Protein
F1ABR9
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q3U0M3
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Publication
7932691 | -
First Author: Bork P
Year: 1994
Journal: J Mol Biol
Title: The immunoglobulin fold. Structural classification, sequence patterns and common core.
Volume: 242
Issue: 4
Pages: 309-20
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Publication
21813777 | J:179269
First Author: Baban B
Year: 2011
Journal: J Immunol
Title: Physiologic control of IDO competence in splenic dendritic cells.
Volume: 187
Issue: 5
Pages: 2329-35
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Protein
O70355
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Protein
Q9JK39
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q149L7
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
Q62151
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
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Protein
Q9EP73
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
Q6XJV4
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q9ES57
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
Q8BTP3
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q9JHJ8
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q80W68
Organism: Mus musculus/domesticus
Length: 789  
Fragment?: false
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Protein
Q7TSU7
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
A7XUX6
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
A7TZF0
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
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Protein
P32507
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q9JLB9
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q8R007
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
E0CY16
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
A0A1W2P6Q2
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: true
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Protein
H9KUZ2
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
B2ZEZ5
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q91WP1
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
B2ZEZ6
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: false
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Protein
F1ABR8
Organism: Mus musculus/domesticus
Length: 312  
Fragment?: false
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Protein
Q9QYL3
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
F1ABS1
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
Q8CG82
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q8BU57
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: false
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Protein
Q9QYL4
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
Q8BVF6
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
M9MMJ5
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Protein
Q3TZU9
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q91VT9
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
A0A0R4J1C6
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
A0A4X8
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
A0A668KLV1
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
J3QP12
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q8K094
Organism: Mus musculus/domesticus
Length: 408  
Fragment?: false
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Protein
Q544C7
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
M0QWY6
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q80XJ5
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q60977
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q8C6F2
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
F1ABS0
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
B2RXY2
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
F1ABR7
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
B2RUE4
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
D3YTK7
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
E9QPS7
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
Q3U472
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: false
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Protein
Q8CH94
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom