|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 6 out of 6 for Bdnf

Category restricted to ProteinDomain (x)

0.021s

Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: This entry represents the neuritin family of proteins, including neuritin-A and B from Xenopus laevis and neuritin-like protein from human and mouse. Neuritin has been shown to promote neurite outgrowth and arborisation in primary embryonic hippocampal and cortical cultures []. Its expression is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3 [].
Protein Domain
Type: Family
Description: This entry represents calcium-responsive transcription factor (CaRF, also known as amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) []. CaRF acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. It binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence [].
Protein Domain
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF), which is involved in the survival of some classes of embryonic neuron (e.g., peripheral sympathetic neurons) []. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ]. Proteins similar to NGF include brain-derived neurotrophic factor (BDNF) and neurotrophins 3 to 7, all of which demonstrate neuron survival and outgrowth activities. Originally purified from pig brain [], the neurotrophin BDNF is expressed in a range of tissues and cell types in the CNS and periphery. It exerts its effects by binding to neurotrophic tyrosine kinase receptor type 2 (NTRK2; also called TrkB) and the low affinity nerve growth factor receptor, p75NTR. While the former receptor mediates the neurotrophin's prosurvival functions, activation of p75NTR by BDNF has been shown to promote apoptosis and to inhibit axonal growth []. BDNF is a key regulator of synaptic plasticity, and plays an important role in learning and memory []. Several lines of evidence suggest that it is also involved in the control of food intake and body weight []. A number of clinical studies have demonstrated an association between aberrant BDNF levels and disorders and disease states, such as depression, epilepsy, bipolar disorder, Parkinson's disease and Alzheimer's disease [].
Protein Domain
Type: Domain
Description: This domain is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins [, ]. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules [, ]. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarisation to modulate cell survival and synaptic plasticity [].
Protein Domain
Type: Family
Description: Translin (also known as TB-RBP for Testis Brain RNA-binding protein, a mouse orthologue), is a paralogue of its binding partner protein TRAX (translin-associated factor-X) []and together they form oligomeric complexes known as C3PO proteins (for component 3 promoter of RNA-induced silencing complex or RISC) []. DNA damage has been proposed to stimulate transport of Translin into nuclei. It binds to RNA and single-stranded DNA, and its selectivity is modulated by interactions with GTP and TRAX. Translin may also regulate dendritic trafficking of BDNF RNAs as well as function as a key activator of siRNA-mediated silencing in Drosophila []. Translin and Trax participate in a variety of nucleic acid metabolism pathways in addition to RNAi and have been implicated in a wide range of biological activities, including mRNA processing, cell growth regulation, spermatogenesis, neuronal development/function, genome stability regulation and carcinogenesis [, , ]; however, their precise role in some of the processes remains unclear.
Protein Domain
Type: Family
Description: During the development of the vertebrate nervous system, many neurons become redundant (because they have died, failed to connect to target cells, etc.) and are eliminated. At the same time, developing neurons send out axon outgrowths that contact their target cells []. Such cells control their degree of innervation (the number of axon connections) by the secretion of various specific neurotrophic factors that are essential for neuron survival. One of these is nerve growth factor (NGF or beta-NGF), a vertebrate protein that stimulates division and differentiation of sympathetic and embryonic sensory neurons [, ]. NGF is mostly found outside the central nervous system (CNS), but slight traces have been detected in adult CNS tissues, although a physiological role for this is unknown []; it has also been found in several snake venoms [, ].NGF is a protein of about 120 residues that is cleaved from a larger precursor molecule. It contains six cysteines all involved in intrachain disulphide bonds.Neurotrophin-3 is a neurotrophic factor related to NGF and BDNF []. NT-3 and its receptor TrkC are found in the spinal cord, and their expression is altered by voluntary exercise [, , ]. In the brain, NT-3 and NT-4/5 may function synergistically with oleic acid to increase GAP-43 expression [].