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Search results 201 to 300 out of 301 for Grm4

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_09
Specimen Label: euxassay_004721_09
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_10
Specimen Label: euxassay_004721_10
Detected: true
Specimen Num: 10
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_11
Specimen Label: euxassay_004721_11
Detected: true
Specimen Num: 11
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_12
Specimen Label: euxassay_004721_12
Detected: true
Specimen Num: 12
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_13
Specimen Label: euxassay_004721_13
Detected: true
Specimen Num: 13
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_14
Specimen Label: euxassay_004721_14
Detected: true
Specimen Num: 14
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_15
Specimen Label: euxassay_004721_15
Detected: true
Specimen Num: 15
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_16
Specimen Label: euxassay_004721_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_17
Specimen Label: euxassay_004721_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_18
Specimen Label: euxassay_004721_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_19
Specimen Label: euxassay_004721_19
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_20
Specimen Label: euxassay_004721_20
Detected: true
Specimen Num: 20
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_21
Specimen Label: euxassay_004721_21
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_22
Specimen Label: euxassay_004721_22
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_23
Specimen Label: euxassay_004721_23
Detected: true
Specimen Num: 23
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_04
Specimen Label: euxassay_004721_04
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_05
Specimen Label: euxassay_004721_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_06
Specimen Label: euxassay_004721_06
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_07
Specimen Label: euxassay_004721_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_08
Specimen Label: euxassay_004721_08
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_16
Specimen Label: euxassay_004721_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_17
Specimen Label: euxassay_004721_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_18
Specimen Label: euxassay_004721_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:2248294
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825240
Age: embryonic day 14.5
Image: euxassay_004721_19
Specimen Label: euxassay_004721_19
Detected: true
Specimen Num: 19
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Publication
22227508 | J:185091
First Author: Davis MJ
Year: 2012
Journal: Behav Brain Res
Title: Measures of anxiety, sensorimotor function, and memory in male and female mGluR4⁻/⁻ mice.
Volume: 229
Issue: 1
Pages: 21-8
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Publication
22145864 | J:182270
First Author: Antflick JE
Year: 2012
Journal: J Neurochem
Title: Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors.
Volume: 120
Issue: 4
Pages: 552-63
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Publication
25529865 | J:273866
First Author: Yasumatsu K
Year: 2015
Journal: J Physiol
Title: Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice.
Volume: 593
Issue: 4
Pages: 1021-34
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Publication
17446080 | J:141725
First Author: Pitsch J
Year: 2007
Journal: Neurobiol Dis
Title: Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.
Volume: 26
Issue: 3
Pages: 623-33
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Publication
24619243 | J:295952
First Author: Becker JA
Year: 2014
Journal: Neuropsychopharmacology
Title: Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.
Volume: 39
Issue: 9
Pages: 2049-60
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Publication
37029391 | J:347467
First Author: Martín R
Year: 2023
Journal: Mol Autism
Title: The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome.
Volume: 14
Issue: 1
Pages: 14
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Publication
32494600 | J:326657
First Author: Siddig S
Year: 2020
Journal: Sci Adv
Title: Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones.
Volume: 6
Issue: 16
Pages: eaay7193
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Publication
22183726 | J:195604
First Author: Yasumatsu K
Year: 2012
Journal: J Physiol
Title: Umami taste in mice uses multiple receptors and transduction pathways.
Volume: 590
Issue: 5
Pages: 1155-70
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Publication
9920659 | J:52411
First Author: Masugi M
Year: 1999
Journal: J Neurosci
Title: Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.
Volume: 19
Issue: 3
Pages: 955-63
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Publication
- | J:58000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 1999
Title: Mouse Genome Informatics Orthology Assignments
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Publication
9069281 | J:39076
First Author: Kaupmann K
Year: 1997
Journal: Nature
Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.
Volume: 386
Issue: 6622
Pages: 239-46
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Publication
27779093 | J:238731
   
First Author: Harrington AJ
Year: 2016
Journal: Elife
Title: MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.
Volume: 5
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Publication
21795692 | J:184110
First Author: Verpelli C
Year: 2011
Journal: J Biol Chem
Title: Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.
Volume: 286
Issue: 40
Pages: 34839-50
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Publication
23416452 | J:197462
First Author: Dillman AA
Year: 2013
Journal: Nat Neurosci
Title: mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex.
Volume: 16
Issue: 4
Pages: 499-506
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Publication
27100196 | J:253278
First Author: Greig LC
Year: 2016
Journal: Neuron
Title: Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.
Volume: 90
Issue: 2
Pages: 261-77
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Publication
35746896 | J:335422
First Author: Špirková A
Year: 2022
Journal: Biol Reprod
Title: Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Volume: 107
Issue: 4
Pages: 916-927
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Publication
25131634 | J:238190
First Author: Alldred MJ
Year: 2015
Journal: J Comp Neurol
Title: Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.
Volume: 523
Issue: 1
Pages: 61-74
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Prss56<glcr4> | MGI:5444189
 
Name: serine protease 56; glaucoma relevant mutation 4
Allele Type: Chemically induced (ENU)
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Allele
Tg(Grm4-EGFP)HY216Gsat | MGI:4847111
Name: transgene insertion HY216, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003784 | STOCK Tg(Grm4-EGFP)HY216Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
8840028 | -
First Author: Makoff A
Year: 1996
Journal: Brain Res Mol Brain Res
Title: Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS.
Volume: 40
Issue: 1
Pages: 165-70
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Publication
8288585 | -
First Author: Okamoto N
Year: 1994
Journal: J Biol Chem
Title: Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
Volume: 269
Issue: 2
Pages: 1231-6
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Protein Domain
IPR001883 | GPCR_3_mGluR7
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.GRM7 mRNA has a widespread distribution in many neuronal cells of the central nervoussystem, with highest levels in the hippocampal formation, cerebral cortexand cerebellum [, ]; it is thus different from the more limitedly expressedGRM4 or GRM6 mRNA []. GRM7 and GRM4 are believed to correspond to theputative L-2-amino-4-phosphonobutyrate receptor, which plays an importantrole in modulation of glutamate transmission in the CNS [].
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Protein
G3UZU3
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Protein
Q8BL09
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
Q8BKZ1
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
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Protein
Q8BKE3
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
Q68ED2
Organism: Mus musculus/domesticus
Length: 915  
Fragment?: false
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Protein
G5E8D5
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Publication
1320017 | -
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
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Publication
1847995 | -
First Author: Masu M
Year: 1991
Journal: Nature
Title: Sequence and expression of a metabotropic glutamate receptor.
Volume: 349
Issue: 6312
Pages: 760-5
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Publication
1656524 | -
First Author: Houamed KM
Year: 1991
Journal: Science
Title: Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume: 252
Issue: 5010
Pages: 1318-21
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Publication
10773016 | -
First Author: Sullivan R
Year: 2000
Journal: J Pharmacol Exp Ther
Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume: 293
Issue: 2
Pages: 460-7
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Publication
9292726 | J:42626
First Author: Ryba NJ
Year: 1997
Journal: Neuron
Title: A new multigene family of putative pheromone receptors.
Volume: 19
Issue: 2
Pages: 371-9
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Publication
17266540 | -
First Author: Bräuner-Osborne H
Year: 2007
Journal: Curr Drug Targets
Title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume: 8
Issue: 1
Pages: 169-84
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Publication
8255296 | -
First Author: Brown EM
Year: 1993
Journal: Nature
Title: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume: 366
Issue: 6455
Pages: 575-80
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Publication
1309649 | -
First Author: Tanabe Y
Year: 1992
Journal: Neuron
Title: A family of metabotropic glutamate receptors.
Volume: 8
Issue: 1
Pages: 169-79
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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