Juvenile amyotrophic lateral sclerosis (ALS) is a form of chronic motor neuron disease characterised by combined upper and lower motor neuron symptoms. Amyotrophic lateral sclerosis 2 (ALS2) is an autosomal recessive form of juvenile ALS and has been mapped to human chromosome 2q33 []. Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein (ALS2CR12), also known as FLACC1, is a putative GTPase regulator and its mutation is linked to the familial amyotrophic lateral sclerosis 2 [].
