Proteins in this family adopt a coiled coil structure, with two antiparallel α-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold [].The precise function of this family is, as yet, unknown []. MTCP1 is found in mitochondria. Mature-T-Cell Proliferation is the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype [].
This entry represents MTCP1 and TCL1A/B from animals. They are encoded from a family of protooncogenes and function as Akt kinase coactivators []. TCL1 also acts as an NFkappaB activator, through the interaction with p300, and as an inhibitor of AP1-dependent transcription []. It affects both hair growth and epidermis integrity and is essential for mouse epidermal keratinocytes proliferation [].
