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Search results 201 to 289 out of 289 for Ahcyl2

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0.026s
Type Details Score
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1842622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Image: ES2; Specimen S74
Specimen Label: ES2; Specimen S74
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1733122
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274322
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1853522
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752322
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3272922
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Note: Expression was not detected in the skeleton (limbs, shoulder, hip).
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1741222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Image: ES2; Specimen S74
Specimen Label: ES2; Specimen S74
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1745822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Image: ES2; Specimen S74
Specimen Label: ES2; Specimen S74
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752422
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309815
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5423141
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: ES2; Specimen S74
Detected: false
Specimen Num: 1
Publication    
First Author: Osada N
Year: 2000
Journal: GenBank Submission
Title: Mus musculus brain cDNA, clone MNCb-5555
Pages: AB041551
Publication      
First Author: The UK Mouse Genome Centre European Consortium
Year: 2000
Journal: Database Release
Title: European Consortium EST Radiation Hybrid Database
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Park PW
Year: 2016
Journal: Korean J Physiol Pharmacol
Title: Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association.
Volume: 20
Issue: 4
Pages: 433-40
Publication
First Author: Ando H
Year: 2003
Journal: J Biol Chem
Title: IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.
Volume: 278
Issue: 12
Pages: 10602-12
Publication
First Author: Devogelaere B
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Volume: 343
Issue: 1
Pages: 49-56
Publication
First Author: Ando H
Year: 2006
Journal: Mol Cell
Title: IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.
Volume: 22
Issue: 6
Pages: 795-806
Publication
First Author: Ando H
Year: 2014
Journal: Biochim Biophys Acta
Title: IRBIT: a regulator of ion channels and ion transporters.
Volume: 1843
Issue: 10
Pages: 2195-204
Publication
First Author: Yang D
Year: 2011
Journal: Neurochem Res
Title: IRBIT: it is everywhere.
Volume: 36
Issue: 7
Pages: 1166-74
Protein Domain
Type: Family
Description: Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, ) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+ [, , , ].This family also includes S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), also known as IRBIT, and S-adenosylhomocysteine hydrolase-like protein 2 (Ahcyl2). Ahcyl1/IRBIT was shown to interact with inositol 1,4,5-trisphosphate receptors (IP3Rs), which function as intracellular Ca(2+) channels, and suppresses IP3 binding of IP3R [, ]. By competing with IP3, it modulates the threshold IP3 concentration required for the activation of the receptor []. Further studies indicate that Ahcyl1/IRBIT is in fact a multifunctional protein that regulates several ion channels and ion transporters [, ]. Despite its homology to S-adenosylhomocysteine hydrolases, Ahcyl1 has neither enzyme activity nor any effects on the enzyme activity of S-adenosylhomocysteine hydrolase []. Ahcyl2 lacks binding activity to IP3R []. Ahcyl2 upregulates NBCe1-B, which plays an important role in intracellular pH regulation [].
Protein
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: true
Publication
First Author: Turner MA
Year: 1998
Journal: Nat Struct Biol
Title: Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Volume: 5
Issue: 5
Pages: 369-76
Publication
First Author: Yamada T
Year: 2005
Journal: Int J Biochem Cell Biol
Title: Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Volume: 37
Issue: 11
Pages: 2417-35
Publication
First Author: Turner MA
Year: 2000
Journal: Cell Biochem Biophys
Title: Structure and function of S-adenosylhomocysteine hydrolase.
Volume: 33
Issue: 2
Pages: 101-25
Publication
First Author: Kloor D
Year: 2004
Journal: Trends Pharmacol Sci
Title: S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action.
Volume: 25
Issue: 6
Pages: 294-7
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 324  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7