|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 106 for Bst2

<< First    < Previous  |  Next >    Last >>
0.039s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
684 | BST2
Type: gene
Organism: human
•
•
•
•
•
Gene
719092 | BST2
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
107055361 | BST2
Type: gene
Organism: chicken
•
•
•
•
•
Gene
378947 | Bst2
Type: gene
Organism: rat
•
•
•
•
•
Gene
609654 | BST2
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
455837 | BST2
Type: gene
Organism: chimpanzee
•
•
•
•
•
Protein Coding Gene
MGI:1916800 | Bst2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Domain
IPR024886 | BST2
Type: Family
Description: Bone marrow stromal antigen 2, also known as tetherin, is an antiretroviral defence protein, that blocks release of enveloped virus from the cell surface [, , ]. Bst2/tetherin contains two membrane anchors which are employed to retain some enveloped viruses, including HIV-1, tethered to the plasma membrane in the absence of virus encoded antagonists []. Its expression is induced by interferon-alpha []and was originally linked to B cell development [].
•
•
•
•
•
Publication
20686043 | J:187565
First Author: Radoshitzky SR
Year: 2010
Journal: J Virol
Title: Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Volume: 84
Issue: 20
Pages: 10569-80
•
•
•
•
•
Gene
105221694 | BISPR
Type: gene
Organism: human
•
•
•
•
•
Protein
Q8R2Q8
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
•
•
•
•
•
Publication
20940320 | -
First Author: Yang H
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into the mechanisms of enveloped virus tethering by tetherin.
Volume: 107
Issue: 43
Pages: 18428-32
•
•
•
•
•
Publication
7607676 | -
First Author: Ishikawa J
Year: 1995
Journal: Genomics
Title: Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.
Volume: 26
Issue: 3
Pages: 527-34
•
•
•
•
•
Publication
18200009 | -
First Author: Neil SJ
Year: 2008
Journal: Nature
Title: Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
Volume: 451
Issue: 7177
Pages: 425-30
•
•
•
•
•
Publication
20399176 | -
First Author: Hinz A
Year: 2010
Journal: Cell Host Microbe
Title: Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.
Volume: 7
Issue: 4
Pages: 314-23
•
•
•
•
•
Publication
19032371 | -
First Author: Kawai S
Year: 2008
Journal: Cancer Sci
Title: Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models.
Volume: 99
Issue: 12
Pages: 2461-6
•
•
•
•
•
Publication
22327075 | J:181846
First Author: Swiecki M
Year: 2012
Journal: J Immunol
Title: Cutting edge: paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection.
Volume: 188
Issue: 6
Pages: 2488-92
•
•
•
•
•
Publication
34416448 | J:343043
 
First Author: Miller KD
Year: 2021
Journal: Virology
Title: Murine BST2/tetherin promotes measles virus infection of neurons.
Volume: 563
Pages: 38-43
•
•
•
•
•
Publication
16920966 | J:139501
First Author: Blasius AL
Year: 2006
Journal: J Immunol
Title: Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation.
Volume: 177
Issue: 5
Pages: 3260-5
•
•
•
•
•
Publication
33357430 | J:302000
First Author: Florez MA
Year: 2020
Journal: Cell Rep
Title: Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.
Volume: 33
Issue: 12
Pages: 108530
•
•
•
•
•
Publication
26311886 | J:343109
First Author: Holmgren AM
Year: 2015
Journal: J Virol
Title: Bst2/Tetherin Is Induced in Neurons by Type I Interferon and Viral Infection but Is Dispensable for Protection against Neurotropic Viral Challenge.
Volume: 89
Issue: 21
Pages: 11011-8
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0031190 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0033751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0033734 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0033660 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0033730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0033440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1916800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0034248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0032765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0033418 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0033572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0033514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0033659 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0033561 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0034265 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0032472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0032881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0021655 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0032309 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
21919738 | J:190272
First Author: Sarojini S
Year: 2011
Journal: DNA Cell Biol
Title: Interferon-induced tetherin restricts vesicular stomatitis virus release in neurons.
Volume: 30
Issue: 12
Pages: 965-74
•
•
•
•
•
Publication
22025715 | J:180252
First Author: Liberatore RA
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo.
Volume: 108
Issue: 44
Pages: 18097-101
•
•
•
•
•
Publication
22284121 | J:187543
 
First Author: Jones PH
Year: 2012
Journal: Retrovirology
Title: Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo.
Volume: 9
Pages: 10
•
•
•
•
•
Publication
23806386 | J:314599
First Author: Jones PH
Year: 2013
Journal: Virology
Title: BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer.
Volume: 444
Issue: 1-2
Pages: 124-39
•
•
•
•
•
Publication
26566124 | J:244727
First Author: Londrigan SL
Year: 2015
Journal: PLoS One
Title: Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection.
Volume: 10
Issue: 11
Pages: e0142925
•
•
•
•
•
Publication
17251550 | J:124022
First Author: Li X
Year: 2007
Journal: Mol Biol Cell
Title: Involvement of a Golgi-resident GPI-anchored protein in maintenance of the Golgi structure.
Volume: 18
Issue: 4
Pages: 1261-71
•
•
•
•
•
Publication
22457621 | J:195397
First Author: Barrett BS
Year: 2012
Journal: PLoS Pathog
Title: A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.
Volume: 8
Issue: 3
Pages: e1002596
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6444257
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444874
Age: postnatal week 5
Specimen Label: wild type control
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6444257
Assay Type: RT-PCR
Annotation Date: 2020-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6444874
Age: postnatal week 5
Specimen Label: miR-183C
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7623828
Assay Type: RT-PCR
Annotation Date: 2024-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7624047
Age: embryonic day 13.5
Specimen Label: WT
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7623828
Assay Type: RT-PCR
Annotation Date: 2024-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7624047
Age: embryonic day 13.5
Specimen Label: Foxg1-/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7623828
Assay Type: RT-PCR
Annotation Date: 2024-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7624047
Age: embryonic day 13.5
Specimen Label: Tgfbr2 cKO
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:7623828
Assay Type: RT-PCR
Annotation Date: 2024-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:7624047
Age: embryonic day 13.5
Specimen Label: Foxg1;Tgfbr2 dKO
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
26846717 | J:250139
 
First Author: Li SX
Year: 2016
Journal: Sci Rep
Title: Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.
Volume: 6
Pages: 20425
•
•
•
•
•
Publication
33245890 | J:302121
First Author: Fu J
Year: 2021
Journal: Exp Cell Res
Title: BST-2/Tetherin is involved in BAFF-enhanced proliferation and survival via canonical NF-κB signaling in neoplastic B-lymphoid cells.
Volume: 398
Issue: 1
Pages: 112399
•
•
•
•
•
Publication
24036213 | J:318192
First Author: Jones PH
Year: 2013
Journal: Cell Signal
Title: Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation.
Volume: 25
Issue: 12
Pages: 2752-61
•
•
•
•
•
Publication
38226173 | J:344312
First Author: Liu H
Year: 2024
Journal: iScience
Title: Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development.
Volume: 27
Issue: 1
Pages: 108722
•
•
•
•
•
Publication
27224923 | J:302089
First Author: Vezzali R
Year: 2016
Journal: Oncotarget
Title: The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.
Volume: 7
Issue: 25
Pages: 37436-37455
•
•
•
•
•
Publication
23341629 | J:193822
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
24843023 | J:227461
 
First Author: Jia X
Year: 2014
Journal: Elife
Title: Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1.
Volume: 3
Pages: e02362
•
•
•
•
•
Allele
Bst2<em2Smoc> | MGI:7288532
Name: bone marrow stromal cell antigen 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6428251 | C57BL/6J-Bst2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Allele
Bst2<em1Smoc> | MGI:7288531
Name: bone marrow stromal cell antigen 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Strain
MGI:6474871 | C57BL/6-Bst2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Ontology Term
- | Inhibition of host tetherin by virus
•
•
•
•
•
Publication
33785592 | J:317407
 
First Author: Manouchehri N
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity.
Volume: 118
Issue: 14
•
•
•
•
•
Publication
33150680 | J:321380
First Author: Yamamoto A
Year: 2021
Journal: FASEB J
Title: Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.
Volume: 35
Issue: 2
Pages: e21158
•
•
•
•
•
Publication
24995382 | -
 
First Author: Liu DX
Year: 2014
Journal: Antiviral Res
Title: Accessory proteins of SARS-CoV and other coronaviruses.
Volume: 109
Pages: 97-109
•
•
•
•
•
Publication
33930332 | -
First Author: Martin-Sancho L
Year: 2021
Journal: Mol Cell
Title: Functional landscape of SARS-CoV-2 cellular restriction.
Volume: 81
Issue: 12
Pages: 2656-2668.e8
•
•
•
•
•
Protein Domain
IPR014888 | ORF7a_SARS-CoV-like
Type: Family
Description: This entry represents the structural accessory protein ORF7a from SARS-CoV-like virus, including SARS-CoV, SARS-CoV-2 and bat SARS-like coronavirus.This entry includes the structural accessory protein ORF7a, also called NS7a, X4 and U122, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavirus subgenera Sarbecovirus (lineage B), including SARS-CoV-2. ORF7a/NS7a from betacoronavirus in the subgenera Sarbecovirus (B lineage) are not related to NS7a proteins from other coronavirus lineages. The structure of the structural accessory protein ORF7a, shows similarities to the immunoglobulin-like fold with some features resembling those of the Dl domain of ICAM-1 and suggests a binding activity to integrin I domains []. In SARS-CoV-infected cells, ORF7a is expressed and retained intracellularly within the Golgi network []. ORF7a is thought to play an important role during the SARS-CoV replication cycle []. Expression studies of ORF7a have shown that biological functions include induction of apoptosis through a caspase-dependent pathway, activation of the p38 mitogen-activated protein kinase signaling pathway, inhibition of host protein translation, and suppression of cell growth progression. These results collectively suggested that ORF7a protein may be involved in virus-host interactions []. Studies in SARS-CoV-2 revealed that ORF7a plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. ORF7a binds to BST2 and sequesters it to the perinuclear region, thereby preventing its antiviral function at cell membrane [].
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom