MIER1, MIER2, MIER3 are ELM-SAINT domain-containing proteins that have been purified with HDAC1 and/or HDAC2, and most likely represent components of distinct histone deacetylase (HDAC) complexes formed around ELM-SANT scaffolds [, ].The gene encoding mesoderm induction early response protein 3 (MIER3) has been identified as a candidate cancer susceptibility gene [].
MTA (metastasis-associated) proteins, including MTA1-3, are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex. Nevertheless, MTA1 and MTA2 have been shown to deacetylate non-histone proteins, such as p53. The expression of MTA proteins have been linked to human cancers [].Mesoderm induction early response proteins (MIER1-3) are ELM2-SANT domain-containing proteins. MIER1 functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity[]. The function of MIER2 and MIER3 is not clear [].
This domain is found at the C terminus of Mesoderm induction early response proteins 1 and 3 (MIER1/3). MIER1 is a transcriptional repressor that regulates the expression of a number of genes including SP1 target genes, recruiting histone deacetylase 1 (HDAC1) through its ELM2 domain. It has two isoforms, alpha and beta, which differ in their C-terminal domains, both of them being able to interact with HDAC1. The gene encoding MIER3 has been identified as a candidate cancer susceptibility gene []. MIER1 and 3 share two regions of high homology, one at the N terminus and the second at the C terminus, represented in this entry, which consists of a short region located immediately downstream of the SANT extension that is 84% identical [, ].
