Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4428360 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828744 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019585_11 |
|
Specimen Label: |
euxassay_019585_11 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428360 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828744 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019585_14 |
|
Specimen Label: |
euxassay_019585_14 |
Detected: |
true |
Specimen Num: |
14 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428360 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828744 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019585_15 |
|
Specimen Label: |
euxassay_019585_15 |
Detected: |
true |
Specimen Num: |
15 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428360 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1791823 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4828744 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_019585_16 |
|
Specimen Label: |
euxassay_019585_16 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4428360 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5422646 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
MH3055; Specimen C4180 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3760108 |
Assay Type: |
RNA in situ |
Annotation Date: |
2007-11-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1881224 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:3760112 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
Not shown |
Detected: |
true |
Specimen Num: |
17 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:26737 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280017 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5816597 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:26737 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-01-04 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280022 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:5816597 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7612572 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-03-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3826220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:7614789 |
Age: |
embryonic day 12.0 |
Image: |
S2G |
Note: |
Expression was detected in the medial portion of the mandibular epithelium. |
Specimen Label: |
S2G |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
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1991 |
Journal: |
Proc Natl Acad Sci U S A |
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Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
•
•
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•
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Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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•
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•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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•
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•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
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HT Experiment |
Series Id: |
GSE68519 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
•
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Publication |
First Author: |
King B |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
Hijacking T cell differentiation: new insights in TLX function in T-ALL. |
Volume: |
21 |
Issue: |
4 |
Pages: |
453-5 |
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•
•
•
•
•
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Publication |
First Author: |
Shimizu H |
Year: |
2000 |
Journal: |
FEBS Lett |
Title: |
Identification of an optimal Ncx binding sequence required for transcriptional activation. |
Volume: |
475 |
Issue: |
3 |
Pages: |
170-4 |
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•
•
•
•
•
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Publication |
First Author: |
Kato Y |
Year: |
2009 |
Journal: |
Pediatr Surg Int |
Title: |
Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice. |
Volume: |
25 |
Issue: |
11 |
Pages: |
961-5 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
This entry represents a group of homeobox proteins, including Tlx1/2/3. They are transcription factors that belong to the to the Hox11 family. In general, they bind to the DNA sequence 5'-CGGTAATTGG-3' []. Tlx1 and Tlx3 are required for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord [, ]. Tlx1, also known as Hox11, is required to maintain normal Wt1 mRNA levels in the developing spleen in mice []. Tlx2, also known as Ncx/Hox11L.1, is required for the adequate development of enteric neurons in mice []. |
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•
•
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Publication |
First Author: |
Cheng L |
Year: |
2005 |
Journal: |
Nat Neurosci |
Title: |
Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. |
Volume: |
8 |
Issue: |
11 |
Pages: |
1510-5 |
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•
•
•
•
•
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Publication |
First Author: |
Chang JC |
Year: |
2013 |
Journal: |
Dev Cell |
Title: |
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits. |
Volume: |
25 |
Issue: |
2 |
Pages: |
182-95 |
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•
•
•
•
•
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Publication |
First Author: |
Della Gatta G |
Year: |
2012 |
Journal: |
Nat Med |
Title: |
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. |
Volume: |
18 |
Issue: |
3 |
Pages: |
436-40 |
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•
•
•
•
•
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Publication |
First Author: |
Dadi S |
Year: |
2012 |
Journal: |
Cancer Cell |
Title: |
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression. |
Volume: |
21 |
Issue: |
4 |
Pages: |
563-76 |
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•
•
•
•
•
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Publication |
First Author: |
Kleppe M |
Year: |
2010 |
Journal: |
Nat Genet |
Title: |
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. |
Volume: |
42 |
Issue: |
6 |
Pages: |
530-5 |
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•
•
•
•
•
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Publication |
First Author: |
Owens BM |
Year: |
2006 |
Journal: |
Br J Haematol |
Title: |
TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage. |
Volume: |
132 |
Issue: |
2 |
Pages: |
216-29 |
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•
•
•
•
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Publication |
First Author: |
Oda A |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1. |
Volume: |
8 |
Issue: |
1 |
Pages: |
8308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shirasawa S |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
Rnx deficiency results in congenital central hypoventilation. |
Volume: |
24 |
Issue: |
3 |
Pages: |
287-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rakowski LA |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma. |
Volume: |
6 |
Issue: |
2 |
Pages: |
e16761 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
284
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
291
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
332
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
333
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
213
|
Fragment?: |
false |
|
•
•
•
•
•
|