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Search results 701 to 800 out of 808 for Pik3r1

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Type Details Score
Publication
27119228 | J:311917
First Author: Qiu X
Year: 2016
Journal: Oncotarget
Title: NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.
Volume: 7
Issue: 21
Pages: 31440-53
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Publication
18322234 | J:132956
First Author: Luyendyk JP
Year: 2008
Journal: J Immunol
Title: Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages.
Volume: 180
Issue: 6
Pages: 4218-26
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Publication
20665729 | J:164696
First Author: Tan Y
Year: 2010
Journal: Genesis
Title: Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.
Volume: 48
Issue: 9
Pages: 531-9
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Publication
12761849 | J:83700
First Author: Koyama N
Year: 2003
Journal: Dev Dyn
Title: EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
Volume: 227
Issue: 2
Pages: 216-26
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Publication
8828042 | J:33579
First Author: Seymour AB
Year: 1996
Journal: Genome Res
Title: An integrated genetic map of the pearl locus of mouse chromosome 13.
Volume: 6
Issue: 6
Pages: 538-44
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Publication
38310234 | J:345099
First Author: Wang X
Year: 2024
Journal: BMC Genomics
Title: Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.
Volume: 25
Issue: 1
Pages: 139
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Publication
21946561 | J:180006
First Author: Yokoyama K
Year: 2011
Journal: EMBO J
Title: NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.
Volume: 30
Issue: 23
Pages: 4739-54
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Publication
21367821 | J:171508
First Author: Ikegami D
Year: 2011
Journal: Development
Title: Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Volume: 138
Issue: 8
Pages: 1507-19
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Publication
32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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Publication
33431871 | J:301083
First Author: Huisman C
Year: 2021
Journal: Nat Commun
Title: The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.
Volume: 12
Issue: 1
Pages: 256
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Publication
29058721 | J:246200
First Author: Löf-Öhlin ZM
Year: 2017
Journal: Nat Cell Biol
Title: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
Volume: 19
Issue: 11
Pages: 1313-1325
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Publication
26002917 | J:239366
First Author: Chintala H
Year: 2015
Journal: Development
Title: The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.
Volume: 142
Issue: 13
Pages: 2364-74
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Publication
31577955 | J:300786
First Author: Zhang Z
Year: 2019
Journal: Cell Rep
Title: The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling.
Volume: 29
Issue: 1
Pages: 49-61.e7
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Publication
34193412 | J:314221
 
First Author: Wang Q
Year: 2021
Journal: Sci Adv
Title: Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.
Volume: 7
Issue: 27
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Publication
26297811 | J:227021
First Author: Mallika C
Year: 2015
Journal: Dev Biol
Title: Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus.
Volume: 407
Issue: 1
Pages: 26-39
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Publication
27318131 | J:239041
 
First Author: Norden DM
Year: 2016
Journal: Neurobiol Aging
Title: Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
Volume: 44
Pages: 22-41
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Publication
19500387 | J:152818
 
First Author: Melnick M
Year: 2009
Journal: BMC Dev Biol
Title: Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Volume: 9
Pages: 32
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
22323595 | J:181994
First Author: Kamileri I
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.
Volume: 109
Issue: 8
Pages: 2995-3000
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Publication
- | J:169366
     
First Author: MouseBookTM
Year: 2005
Journal: Unpublished
Title: Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK.
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Publication
11591653 | J:103507
First Author: Suzuki H
Year: 2001
Journal: Genome Res
Title: Protein-protein interaction panel using mouse full-length cDNAs.
Volume: 11
Issue: 10
Pages: 1758-65
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pik3r1<em1Ekd> | MGI:7539172
Name: phosphoinositide-3-kinase regulatory subunit 1; endonuclease-mediated mutation 1, Elissa K Deenick
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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DO Term
DOID:0081139 | agammaglobulinemia 7
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Allele
Pik3r1<tm1.1Geno> | MGI:6153554
Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1.1, Genoway
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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DO Term
DOID:0111949 | immunodeficiency 36
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Genotype
Genotype
Symbol: Pik3r1/Pik3r1<+>
Background: involves: C57BL/6 * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0111454 | SHORT syndrome
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Allele
Tg(Myh6-Pik3r1/PIK3CA)BSiz | MGI:3619920
Name: transgene insertion B, Seigo Izumo
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Publication
20974681 | J:179541
First Author: Yang KC
Year: 2010
Journal: J Physiol
Title: Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.
Volume: 588
Issue: Pt 24
Pages: 5015-32
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Publication
23028587 | J:191872
First Author: Li C
Year: 2012
Journal: PLoS One
Title: Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.
Volume: 7
Issue: 9
Pages: e44712
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Genotype
Genotype
Symbol: Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-IGF1R)7Jmcm/? Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
33577435 | J:305039
First Author: Weeks KL
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Volume: 320
Issue: 4
Pages: H1470-H1485
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Publication
10835352 | J:62707
First Author: Shioi T
Year: 2000
Journal: EMBO J
Title: The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
Volume: 19
Issue: 11
Pages: 2537-48
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Publication
19122165 | J:146552
First Author: Rigor DL
Year: 2009
Journal: Am J Physiol Heart Circ Physiol
Title: Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function.
Volume: 296
Issue: 3
Pages: H566-72
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Publication
23001375 | J:194561
First Author: Ritchie RH
Year: 2012
Journal: Diabetologia
Title: Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Volume: 55
Issue: 12
Pages: 3369-81
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Genotype
Genotype
Symbol: Tg(Myh6-Pik3ca)1Siz/? Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Publication
17202264 | J:119070
First Author: McMullen JR
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.
Volume: 104
Issue: 2
Pages: 612-7
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Publication
11909972 | J:75780
First Author: Shioi T
Year: 2002
Journal: Mol Cell Biol
Title: Akt/protein kinase B promotes organ growth in transgenic mice.
Volume: 22
Issue: 8
Pages: 2799-809
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Publication
22038742 | J:194876
First Author: Yang KC
Year: 2012
Journal: Cardiovasc Res
Title: Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.
Volume: 93
Issue: 2
Pages: 252-62
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Publication
29217479 | J:260695
First Author: Tham YK
Year: 2018
Journal: Biochim Biophys Acta
Title: Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.
Volume: 1863
Issue: 3
Pages: 219-234
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Publication
20237330 | J:172261
First Author: Lin RC
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.
Volume: 30
Issue: 4
Pages: 724-32
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Publication
14597618 | J:87944
First Author: McMullen JR
Year: 2004
Journal: J Biol Chem
Title: The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
Volume: 279
Issue: 6
Pages: 4782-93
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Publication
26216516 | J:285881
First Author: Borralleras C
Year: 2015
Journal: Mol Ther
Title: Intracisternal Gtf2i Gene Therapy Ameliorates Deficits in Cognition and Synaptic Plasticity of a Mouse Model of Williams-Beuren Syndrome.
Volume: 23
Issue: 11
Pages: 1691-1699
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Publication
25238855 | J:261582
First Author: Young ME
Year: 2014
Journal: J Biol Rhythms
Title: Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart.
Volume: 29
Issue: 4
Pages: 257-76
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Publication
32127496 | J:308849
 
First Author: Kharbanda A
Year: 2020
Journal: Sci Signal
Title: Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
Volume: 13
Issue: 621
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Publication
29472543 | J:280454
First Author: Zheng S
Year: 2018
Journal: Cell Death Dis
Title: DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
Volume: 9
Issue: 3
Pages: 310
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Publication
34502349 | J:340429
 
First Author: Solich J
Year: 2021
Journal: Int J Mol Sci
Title: MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype.
Volume: 22
Issue: 17
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Publication
28787439 | J:247918
First Author: Ji ZH
Year: 2017
Journal: PLoS One
Title: Cutaneous transcriptome analysis in NIH hairless mice.
Volume: 12
Issue: 8
Pages: e0182463
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Publication
34516985 | J:313505
First Author: Hu L
Year: 2021
Journal: Exp Cell Res
Title: MicroRNA-7 overexpression positively regulates the CD8+ SP cell development via targeting PIK3R1.
Volume: 407
Issue: 2
Pages: 112824
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Publication
31048499 | J:276334
First Author: Yoo JH
Year: 2019
Journal: Cancer Res
Title: The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.
Volume: 79
Issue: 11
Pages: 2892-2908
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Publication
14504291 | J:114127
First Author: Ueki K
Year: 2003
Journal: J Biol Chem
Title: Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
Volume: 278
Issue: 48
Pages: 48453-66
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Publication
23606743 | J:328153
First Author: Motohashi N
Year: 2013
Journal: J Cell Sci
Title: Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis.
Volume: 126
Issue: Pt 12
Pages: 2678-91
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Publication
9488453 | -
First Author: Yu J
Year: 1998
Journal: Mol Cell Biol
Title: Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit.
Volume: 18
Issue: 3
Pages: 1379-87
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Protein Domain
IPR044124 | ISH2_PIK3R1
Type: Domain
Description: Phosphoinositide 3-kinases (PI3Ks) are essential for cell growth, migration, and survival. Class IA PI3Ks are heterodimers of a p110 catalytic (C) subunit and a p85-related regulatory (R) subunit []. p110 is composed of an adaptor-binding domain, a Ras-binding domain, a C2 domain, a helical domain, and a kinase domain. p85 is composed of an SH3 domain, a RhoGap domain, a N-terminal SH2 (nSH2) domain, a inter SH2 (iSH2) domain, and C-terminal (cSH2) domain. There are two inhibitory interactions between p110alpha and p85 of P13K: 1) p85 nSH2 domain with the C2, helical, and kinase domains of p110alpha and 2) p85 iSH2 domain with C2 domain of p110alpha. There are three inhibitory interactions between p110beta and p85 of P13K: 1) p85 nSH2 domain with the C2, helical, and kinase domains of p110beta, 2) p85 iSH2 domain with C2 domain of p110beta, and 3) p85 cSH2 domain with the kinase domain of p110beta []. p110beta is oncogenic as a wild type protein while p110alpha lacks this ability. One explanation is that the regulation of p110beta by p85 is unique because of the addition of inhibitory contacts from the cSH2 domain and the loss of contacts in the iSH2 domain []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [].In mammals, there are multiple class IA PI3K regulatory and catalytic subunits. There are three genes that encode at least five different regulatory subunit proteins (p85alpha, p55alpha, p50alpha, p85beta, and p55gamma) and three genes encoding three catalytic subunits (p110alpha, p110beta, and p110delta) [].Among all the class IA PI3K combinations, p85alpha/p110alpha heterodimer has been the most intensely investigated. p110alpha has been shown to be stabilized and inhibited by dimerization with p85alpha []. Moreover, p85alpha (also called PIK3R1) has functions independent of its PI3K regulatory role. It can independently stimulate signalling pathways involved in cytoskeletal rearrangements []. PIK3R1 has been shown to play an important role in insulin signalling [].This entry represents the iSH2 domain found in PIK3R1.
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Publication
37287451 | J:346337
 
First Author: Jing Z
Year: 2023
Journal: Front Cell Dev Biol
Title: Epigenetic and transcriptomic alterations in the ClC-3-deficient mice consuming a normal diet.
Volume: 11
Pages: 1196684
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Publication
21362552 | -
First Author: Zhang X
Year: 2011
Journal: Mol Cell
Title: Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Volume: 41
Issue: 5
Pages: 567-78
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