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Search results 101 to 121 out of 121 for Tbl1xr1

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Type

Details

Score

Publication

11063877 | -

First Author:	Zhang X
Year:	2000
Journal:	Exp Hematol
Title:	Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors.
Volume:	28
Issue:	11
Pages:	1286-96

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Allele

Tbl1xr1<em2Smoc> | MGI:7292696

Name:	transducin (beta)-like 1X-linked receptor 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Allele

Tbl1xr1<em1Smoc> | MGI:7292695

Name:	transducin (beta)-like 1X-linked receptor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Conditional ready, No functional change

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DO Term

DOID:0070071 | autosomal dominant intellectual developmental disorder 41

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Allele

Tbl1xr1<em2H> | MGI:7469825

Name:	transducin (beta)-like 1X-linked receptor 1; endonuclease-mediated mutation 2, Harwell
Allele Type:	Endonuclease-mediated
Attribute String:	Humanized sequence

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Allele

Gt(ROSA)26Sor<em1(CAG-TBL1XR1/TP63,-EGFP)Mybr> | MGI:7579420

Name:	gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Myles Brown
Allele Type:	Endonuclease-mediated
Attribute String:	Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter

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Strain

MGI:6771208 | C57BL/6J-Tbl1xr1<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

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DO Term

DOID:0081362 | Pierpont syndrome

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Genotype

Symbol:	Tbl1xr1/Tbl1xr1
Background:	C57BL/6J-Tbl1xr1
Zygosity:	hm
Has Mutant Allele:	true

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Publication

37729434 | J:343472

First Author:	Wu G
Year:	2023
Journal:	Sci Transl Med
Title:	TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence.
Volume:	15
Issue:	714
Pages:	eadi7244

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Publication

11711434 | -

First Author:	Pijnappel WW
Year:	2001
Journal:	Genes Dev
Title:	The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program.
Volume:	15
Issue:	22
Pages:	2991-3004

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Publication

11032805 | -

First Author:	Boulton SJ
Year:	2000
Journal:	EMBO J
Title:	A role for Ebi in neuronal cell cycle control.
Volume:	19
Issue:	20
Pages:	5376-86

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Publication

18356294 | -

First Author:	Zhu J
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance.
Volume:	105
Issue:	12
Pages:	4945-50

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Protein Domain

IPR045183 | Ebi-like

Type:

Family

Description:

This entry includes a group of F-box-like/WD repeat-containing proteins, including Hif2/Sif2 from yeasts, Ebi from Drosophila melanogaster, TBL1X /TBL1XR1 from humans and HOS15 from Arabidopsis. Hif2/Sif2 is part of the set3 histone deacetylase complex involved in chromatin remodeling and transcription regulation []. Ebi promotes the degradation of a repressor of neuronal differentiation (Ttk88) and also limits S phase entry []. TBL1X /TBL1XR1 act as a bridge between the corepressor protein and histones by interacting with both of them within the complex. The N terminus of TBL1X interacts with the N termini of both H2B and H4 histones, and the first three C-terminal WD40-repeats of TBL1X interact with the corepressor complex []. TBL1X /TBL1XR1 serve as specific adaptors for the recruitment of the ubiquitin conjugating/19S proteasome complex []and are important for both formation and dismantling of the NCOR complex, which is a corepressor complex. Mutations of the TBL1XR1 gene have been linked to several neurodevelopmental disorders, such as spanning from autism spectrum disorders (ASD), West syndrome, schizophrenia (SCZ), intellectual disability [].HOS15 represses genes associated with abiotic stress tolerance through histone deacetylation in Arabidopsis [].

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Protein

Q8BR49

Organism:	Mus musculus/domesticus
Length:	999
Fragment?:	true

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Protein

Q3UF38

Organism:	Mus musculus/domesticus
Length:	236
Fragment?:	false

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Protein

Q9QXE7

Organism:	Mus musculus/domesticus
Length:	527
Fragment?:	false

•

Publication

23806337 | J:203468

First Author:	Park J
Year:	2013
Journal:	Mol Cell
Title:	SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Volume:	50
Issue:	6
Pages:	919-30

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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