This entry represents the SAM (sterile alpha motif) domain repeat 1 of SASH1, which is a predicted protein-protein interaction domain. SASH1 contains an SH3 domain and two SAM domains, and is a member of the SH3/SAM adapter molecules family. SASH1 has been identified as a tumour suppressor and critical protein in signal transduction [, ].
SASH1 is a potential tumour suppressor in breast and colon cancer. Its decreased expression is associated with aggressive tumour growth, metastasis, and poor prognosis [, ]. It is widely expressed in normal tissues (except lymphocytes and dendritic cells) and is localized in the nucleus and the cytoplasm []. SASH1 interacts with the oncoprotein cortactin and is important in cell migration and adhesion. It is a member of the SLY family of proteins, which are adaptor proteins containing a central conserved region with a bipartite nuclear localization signal (NLS) as well as SAM (sterile alpha motif) and SH3 domains [].This entry represents the SH3 domain of SASH1.
This entry represents the SAM (sterile alpha motif) repeat 2 of SASH1, which is a predicted protein-protein interaction domain. SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a tumour suppressor and critical protein in signal transduction [, ].
