Type |
Details |
Score |
Genotype |
Symbol: |
Gck/Gck<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck Tg(Ins2-cre)25Mgn/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> Tg(Ins2-cre)25Mgn/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck Speer6-ps1/Speer6-ps1<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> Speer6-ps1/Speer6-ps1<+> |
Background: |
involves: C57BL/6 * DBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> |
Background: |
either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J) |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck |
Background: |
either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * DBA/2J) |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> |
Background: |
129S6/SvEvTac-Gck |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck |
Background: |
129S6/SvEvTac-Gck |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> |
Background: |
involves: C3HeB/FeJ |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1308
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1345
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1300
|
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
glucokinase; targeted mutation 2885, Bernard Thorens |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
glucokinase; targeted mutation 1, Takashi Kadowaki |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, chemically induced mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion NH76, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation, coisogenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, chemically induced mutation |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion TG7, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion #, Jeffrey M Friedman |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> |
Background: |
involves: C57BL/6NTac |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Stanley S |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia. |
Volume: |
18 |
Issue: |
4 |
Pages: |
596-607 |
|
•
•
•
•
•
|
Allele |
Name: |
glucokinase; mutation 2, Bruce Beutler |
Allele Type: |
Chemically induced (ENU) |
Attribute String: |
Not Specified |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, coisogenic, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
chemically induced mutation, mutant stock |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck |
Background: |
C57BL/6J-Gck |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
da Silva Xavier G |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells. |
Volume: |
402 |
Issue: |
2 |
Pages: |
252-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanai-Azuma M |
Year: |
1999 |
Journal: |
Mech Dev |
Title: |
Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. |
Volume: |
89 |
Issue: |
1-2 |
Pages: |
155-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe H |
Year: |
2023 |
Journal: |
Sci Transl Med |
Title: |
Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes. |
Volume: |
15 |
Issue: |
681 |
Pages: |
eabq4126 |
|
•
•
•
•
•
|
Publication |
First Author: |
Præstholm SM |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage. |
Volume: |
37 |
Issue: |
5 |
Pages: |
109938 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramjaun AR |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. |
Volume: |
276 |
Issue: |
31 |
Pages: |
28913-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su YC |
Year: |
1997 |
Journal: |
EMBO J |
Title: |
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. |
Volume: |
16 |
Issue: |
6 |
Pages: |
1279-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brun PJ |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass. |
Volume: |
29 |
Issue: |
2 |
Pages: |
671-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vinod M |
Year: |
2016 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
MiR-206 is expressed in pancreatic islets and regulates glucokinase activity. |
Volume: |
311 |
Issue: |
1 |
Pages: |
E175-E185 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamoto Y |
Year: |
2017 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Preserving expression of Pdx1 improves β-cell failure in diabetic mice. |
Volume: |
483 |
Issue: |
1 |
Pages: |
418-424 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oosterveer MH |
Year: |
2012 |
Journal: |
J Clin Invest |
Title: |
LRH-1-dependent glucose sensing determines intermediary metabolism in liver. |
Volume: |
122 |
Issue: |
8 |
Pages: |
2817-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kulkarni RN |
Year: |
2002 |
Journal: |
Nat Genet |
Title: |
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. |
Volume: |
31 |
Issue: |
1 |
Pages: |
111-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong X |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e74340 |
|
•
•
•
•
•
|
Publication |
First Author: |
Halmos KC |
Year: |
2015 |
Journal: |
Neuroscience |
Title: |
Molecular and functional changes in glucokinase expression in the brainstem dorsal vagal complex in a murine model of type 1 diabetes. |
Volume: |
306 |
|
Pages: |
115-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maiorana A |
Year: |
2015 |
Journal: |
Orphanet J Rare Dis |
Title: |
Ketogenic diet in a patient with congenital hyperinsulinism: a novel approach to prevent brain damage. |
Volume: |
10 |
|
Pages: |
120 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beddow SA |
Year: |
2019 |
Journal: |
Endocrinology |
Title: |
PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats. |
Volume: |
160 |
Issue: |
1 |
Pages: |
205-219 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gck/Gck<+> Tg(Ins1-cre/ERT)1Lphi/? |
Background: |
involves: C57BL/6 * C57BL/6J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson JD |
Year: |
2011 |
Journal: |
Diabetes |
Title: |
Direct recruitment of insulin receptor and ERK signaling cascade to insulin-inducible gene loci. |
Volume: |
60 |
Issue: |
1 |
Pages: |
127-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Won Y |
Year: |
2024 |
Journal: |
Gastroenterology |
Title: |
Oncogenic Fatty Acid Metabolism Rewires Energy Supply Chain in Gastric Carcinogenesis. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rozenberg K |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Sarcopoterium spinosum extract improved insulin sensitivity in mice models of glucose intolerance and diabetes. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e0196736 |
|
•
•
•
•
•
|
Publication |
First Author: |
Obata A |
Year: |
2019 |
Journal: |
Diabetologia |
Title: |
Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice. |
Volume: |
62 |
Issue: |
7 |
Pages: |
1225-1236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magnuson MA |
Year: |
2013 |
Journal: |
Cell Metab |
Title: |
Pancreas-specific Cre driver lines and considerations for their prudent use. |
Volume: |
18 |
Issue: |
1 |
Pages: |
9-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|