Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
|
UniProt Feature |
Begin: |
2 |
Description: |
Glutathione S-transferase LANCL1 |
Type: |
chain |
End: |
399 |
|
•
•
•
•
•
|
Allele |
Name: |
LanC (bacterial lantibiotic synthetase component C)-like 1; targeted mutation 1.1 Paul Worley |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
173
|
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
399
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung CH |
Year: |
2007 |
Journal: |
Biochemistry |
Title: |
Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. |
Volume: |
46 |
Issue: |
11 |
Pages: |
3262-9 |
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•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Paul Worley |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
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•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2009 |
Journal: |
Genes Dev |
Title: |
Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1387-92 |
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•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Nes-cre)1Kln/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Ddx4-cre)1Dcas/? |
Background: |
involves: C57BL/6 * FVB |
Zygosity: |
cn |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Publication |
First Author: |
Asaduzzaman SM |
Year: |
2009 |
Journal: |
J Biosci Bioeng |
Title: |
Lantibiotics: diverse activities and unique modes of action. |
Volume: |
107 |
Issue: |
5 |
Pages: |
475-87 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [, , ]; subtilin biosynthesis protein SpaC from Bacillus subtilis [, ]; epidermin biosynthesis protein EpiC from Staphylococcus epidermidis []; nisin biosynthesis protein NisC from Lactococcus lactis [, , ]; GCR2 from Arabidopsis thaliana []; and many others. The 3D structure of the lantibiotic cyclase from L. lactis has been determined by X-ray crystallography to 2.5A resolution []. The globular structure is characterised by an all-alpha fold, in which an outer ring of helices envelops an inner toroid composed of 7 shorter, hydrophobic helices. This 7-fold hyrophobic periodicity has led several authors to claim various members of the family, including eukaryotic LanC-1 and GCR2, to be novel G protein-coupled receptors [, ]; some of these claims have since been corrected [, , ]. The C terminus of the lantibiotic biosynthesis protein LanM is homologous to LanC [, ]. LanC-like protein 1 (included in this family) has been shown to function as a glutathione transferase, and as such has been renamed to Glutathione S-transferase LANCL1 []. |
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Publication |
First Author: |
Zhang Q |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Evolution of lanthipeptide synthetases. |
Volume: |
109 |
Issue: |
45 |
Pages: |
18361-6 |
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•
•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
450
|
Fragment?: |
false |
|
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
420
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
441
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung YJ |
Year: |
1992 |
Journal: |
J Bacteriol |
Title: |
The subtilin gene of Bacillus subtilis ATCC 6633 is encoded in an operon that contains a homolog of the hemolysin B transport protein. |
Volume: |
174 |
Issue: |
4 |
Pages: |
1417-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schnell N |
Year: |
1992 |
Journal: |
Eur J Biochem |
Title: |
Analysis of genes involved in the biosynthesis of lantibiotic epidermin. |
Volume: |
204 |
Issue: |
1 |
Pages: |
57-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2007 |
Journal: |
Science |
Title: |
A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. |
Volume: |
315 |
Issue: |
5819 |
Pages: |
1712-6 |
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•
•
•
•
•
|
Publication |
First Author: |
Park S |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. |
Volume: |
63 |
Issue: |
3 |
Pages: |
723-7 |
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•
•
•
•
•
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Publication |
First Author: |
Engelke G |
Year: |
1992 |
Journal: |
Appl Environ Microbiol |
Title: |
Biosynthesis of the lantibiotic nisin: genomic organization and membrane localization of the NisB protein. |
Volume: |
58 |
Issue: |
11 |
Pages: |
3730-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayer H |
Year: |
1998 |
Journal: |
Biochim Biophys Acta |
Title: |
Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor. |
Volume: |
1395 |
Issue: |
3 |
Pages: |
301-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Illingworth CJ |
Year: |
2008 |
Journal: |
Biophys Chem |
Title: |
Criteria for confirming sequence periodicity identified by Fourier transform analysis: application to GCR2, a candidate plant GPCR? |
Volume: |
133 |
Issue: |
1-3 |
Pages: |
28-35 |
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•
•
•
•
•
|
Publication |
First Author: |
Gao Y |
Year: |
2007 |
Journal: |
Plant J |
Title: |
Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis. |
Volume: |
52 |
Issue: |
6 |
Pages: |
1001-13 |
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•
•
•
•
•
|
Publication |
First Author: |
Kuipers OP |
Year: |
1993 |
Journal: |
Eur J Biochem |
Title: |
Characterization of the nisin gene cluster nisABTCIPR of Lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity. |
Volume: |
216 |
Issue: |
1 |
Pages: |
281-91 |
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•
•
•
•
•
|
Publication |
First Author: |
Klein C |
Year: |
1992 |
Journal: |
Appl Environ Microbiol |
Title: |
Analysis of genes involved in biosynthesis of the lantibiotic subtilin. |
Volume: |
58 |
Issue: |
1 |
Pages: |
132-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li B |
Year: |
2006 |
Journal: |
Science |
Title: |
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. |
Volume: |
311 |
Issue: |
5766 |
Pages: |
1464-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Engelke G |
Year: |
1994 |
Journal: |
Appl Environ Microbiol |
Title: |
Regulation of nisin biosynthesis and immunity in Lactococcus lactis 6F3. |
Volume: |
60 |
Issue: |
3 |
Pages: |
814-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
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•
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