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Search results 801 to 837 out of 837 for Clu

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0.019s

Type

Details

Score

Allele

Clu<em1.1(cre/ERT2)Algr> | MGI:6716263

Name:	clusterin; endonuclease-mediated mutation 1, Alex Gregorieff
Allele Type:	Endonuclease-mediated
Attribute String:	Inducible, Recombinase

•

Allele

Tg(Clu-EGFP)OD95Gsat | MGI:4940543

Name:	transgene insertion OD95, GENSAT Project at Rockefeller University
Allele Type:	Transgenic
Attribute String:	Reporter

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Strain

MGI:6770661 | C57BL/6-Clu<em3Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Strain

MGI:5004304 | STOCK Tg(Clu-EGFP)OD95Gsat/Mmucd

Attribute String:

mutant stock, transgenic

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Genotype

Symbol:	Clu/Clu<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background:	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCrl
Zygosity:	cn
Has Mutant Allele:	true

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Protein

Q3V245

Organism:	Mus musculus/domesticus
Length:	76
Fragment?:	true

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Publication

21953454 | -

First Author:	Leskov KS
Year:	2011
Journal:	J Biol Chem
Title:	CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor.
Volume:	286
Issue:	46
Pages:	40083-90

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Publication

22588555 | -

First Author:	Kususda Y
Year:	2012
Journal:	Br J Cancer
Title:	Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model.
Volume:	106
Issue:	12
Pages:	1945-52

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Publication

21505792 | -

First Author:	Wyatt AR
Year:	2011
Journal:	Cell Mol Life Sci
Title:	Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
Volume:	68
Issue:	23
Pages:	3919-31

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Publication

19535339 | -

First Author:	Wyatt AR
Year:	2009
Journal:	J Biol Chem
Title:	Structural characterization of clusterin-chaperone client protein complexes.
Volume:	284
Issue:	33
Pages:	21920-7

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Publication

22025968 | -

First Author:	Kim N
Year:	2011
Journal:	Anat Cell Biol
Title:	Proapoptotic role of nuclear clusterin in brain.
Volume:	44
Issue:	3
Pages:	169-75

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Publication

11720815 | -

First Author:	Li DQ
Year:	2001
Journal:	FEMS Immunol Med Microbiol
Title:	Binding of human clusterin by Staphylococcus epidermidis.
Volume:	31
Issue:	3
Pages:	197-202

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Publication

10675623 | J:60371

First Author:	Zhang Q
Year:	2000
Journal:	Gene
Title:	Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA.
Volume:	243
Issue:	1-2
Pages:	151-60

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Publication

14507903 | -

First Author:	Zhang Q
Year:	2003
Journal:	Invest Ophthalmol Vis Sci
Title:	Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.
Volume:	44
Issue:	10
Pages:	4542-9

•

Protein Domain

IPR016016 | Clusterin

Type:

Family

Description:

Clusterin (Clu), also known as apolipoprotein J, is a vertebrate glycoprotein []. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initial leader peptide. This ~60kDa pre-sCLU protein is proteolytically cleaved into alpha- and beta-subunits and further glycosylated to form mature disulfide-linked heterodimeric secretory CLU (sCLU). sCLU is an 80kDa protein and acts as a molecular chaperone, scavenging denatured proteins outside cells [, ]. sCLU possesses nonspecific binding activity to hydrophobic domains of various non-native proteins [], binds to some bacteria and bacterial proteins [], and interacts with different immune molecules [].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required forcell death. The sCLU protein is cytoprotective and anti-apoptotic, whereas the nCLU protein is pro-apoptotic [, , ].

•

Protein Domain

IPR000753 | Clusterin-like

Type:

Family

Description:

Clusterin (Clu), also known as apolipoprotein J, is a vertebrate glycoprotein []. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initial leader peptide. This ~60kDa pre-sCLU protein is proteolytically cleaved into alpha- and beta-subunits and further glycosylated to form mature disulfide-linked heterodimeric secretory CLU (sCLU). sCLU is an 80kDa protein and acts as a molecular chaperone, scavenging denatured proteins outside cells [, ]. sCLU possesses nonspecific binding activity to hydrophobic domains of various non-native proteins [], binds to some bacteria and bacterial proteins [], and interacts with different immune molecules [].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death. The sCLU protein is cytoprotective and anti-apoptotic, whereas the nCLU protein is pro-apoptotic [, , ].This family also includes clusterin-like protein 1 (CLUL1), which is expressed specifically in cone photoreceptor cells []and is likely to be necessary for normal cone function [].

•

Protein

E9PUU2

Organism:	Mus musculus/domesticus
Length:	225
Fragment?:	true

•

Protein

E9PXG5

Organism:	Mus musculus/domesticus
Length:	233
Fragment?:	true

•

Protein

E9Q8Y5

Organism:	Mus musculus/domesticus
Length:	265
Fragment?:	true

•

Protein

E9Q2G2

Organism:	Mus musculus/domesticus
Length:	209
Fragment?:	true

•

Protein

E9Q9B8

Organism:	Mus musculus/domesticus
Length:	203
Fragment?:	true

•

Publication

22956607 | J:214056

First Author:	Matthaei M
Year:	2012
Journal:	Invest Ophthalmol Vis Sci
Title:	Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy.
Volume:	53
Issue:	10
Pages:	6718-27

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Publication

11272792 | J:67915

First Author:	Lindgren G
Year:	2001
Journal:	Chromosome Res
Title:	Mapping of 13 horse genes by fluorescence in-situ hybridization (FISH) and somatic cell hybrid analysis.
Volume:	9
Issue:	1
Pages:	53-9

•

Publication

18397380 | J:151157

First Author:	Mulligan MK
Year:	2008
Journal:	Genes Brain Behav
Title:	Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains.
Volume:	7
Issue:	6
Pages:	677-89

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Publication

28971894 | J:253645

First Author:	Saewu A
Year:	2017
Journal:	Reproduction
Title:	Clusterin in the mouse epididymis: possible roles in sperm maturation and capacitation.
Volume:	154
Issue:	6
Pages:	867-880

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Publication

32913257 | J:296152

First Author:	He J
Year:	2020
Journal:	Sci Rep
Title:	Glomerular clusterin expression is increased in diabetic nephropathy and protects against oxidative stress-induced apoptosis in podocytes.
Volume:	10
Issue:	1
Pages:	14888

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Publication

33052230 | J:313884

First Author:	Chen Z
Year:	2020
Journal:	Theranostics
Title:	Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity.
Volume:	10
Issue:	25
Pages:	11520-11534

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Protein

Q06890

Organism:	Mus musculus/domesticus
Length:	448
Fragment?:	false

•

Protein

Q9JK98

Organism:	Mus musculus/domesticus
Length:	372
Fragment?:	false

•

Protein

Q549A5

Organism:	Mus musculus/domesticus
Length:	448
Fragment?:	false

•

Publication

1585460 | -

First Author:	Jenne DE
Year:	1992
Journal:	Trends Biochem Sci
Title:	Clusterin: the intriguing guises of a widely expressed glycoprotein.
Volume:	17
Issue:	4
Pages:	154-9

•

Protein

Q3ZRW6

Organism:	Mus musculus/domesticus
Length:	464
Fragment?:	false

•

Protein Domain

IPR016014 | Clusterin_N

Type:

Domain

Description:

Clusterin is a vertebrate glycoprotein [], the exact function of which is not yet clear. Clusterin expression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initialleader peptide. This ~60kDa pre-sCLU protein is further glycosylated and proteolytically cleaved into alpha- and beta-subunits, held together by disulphide bonds.External sCLU is an 80kDa protein and may act as a molecular chaperone, scavenging denatured proteins outside cells following specific stress-induced injury such as heat shock. sCLU possesses nonspecific binding activity to hydrophobic domains of various proteins in vitro[].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death.Clusterin is synthesized as a precursor polypeptide of about 400 amino acids which is post-translationally cleaved to form two subunits of about 200 amino acids each. The two subunits are linked by five disulphide bonds to form anantiparallel ladder-like structure []. In each of the mature subunits the five cysteines that are involved in disulphide bonds are clustered in domains of about 30 amino acids located in the central part of the subunits.This entry represents the N-terminal domain of the clusterin precursor.

•

Protein Domain

IPR016015 | Clusterin_C

Type:

Domain

Description:

Clusterin is a vertebrate glycoprotein [], the exact function of which is not yet clear. Clusterinexpression is complex, appearing as different forms indifferent cell compartments. One set of proteins is directed for secretion, and other clusterin species are expressed in thecytoplasm and nucleus. The secretory form of the clusterin protein (sCLU) is targeted to the ER by an initialleader peptide. This ~60kDa pre-sCLU protein is further glycosylated and proteolytically cleaved into alpha- and beta-subunits, held together by disulphide bonds.External sCLU is an 80kDa protein and may act as a molecular chaperone, scavenging denatured proteins outside cells following specific stress-induced injury such as heat shock. sCLU possesses nonspecific binding activity to hydrophobic domains of various proteins in vitro[].A specific nuclear form of CLU (nCLU) acts as a pro-death signal, inhibiting cell growth andsurvival. ThenCLU protein has two coiled-coil domains, one at its N terminus that is unable to bind Ku70, and a C-terminal coiled-coil domain that is uniquely able to associatewith Ku70 and is minimally required for cell death.Clusterin is synthesized as a precursor polypeptide of about 400 amino acids which is post-translationally cleaved to form two subunits of about 200 amino acids each. The two subunits are linked by five disulphide bonds to form anantiparallel ladder-like structure []. In each of the mature subunits the five cysteines that are involved in disulphide bonds are clustered in domains of about 30 amino acids located in the central part of the subunits.This entry represents the C-terminal domain of the custerin precursor.

•

Publication

25051234 | J:219013

First Author:	Zhou Y
Year:	2014
Journal:	PLoS One
Title:	Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.
Volume:	9
Issue:	7
Pages:	e103187

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Publication

1491011 | -

First Author:	Choi-Miura NH
Year:	1992
Journal:	J Biochem
Title:	Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J).
Volume:	112
Issue:	4
Pages:	557-61

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Publication

- | J:100256

First Author:	The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year:	2005
Journal:	Database Download
Title:	MGI download of GENSAT transgene data

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