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Search results 401 to 450 out of 450 for Sirt6

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0.049s

Type

Details

Score

HT Experiment

E-GEOD-21965 | Expression data from WT SIRT6 and SIRT6 albumin CRE conditional mice

Series Id:	GSE21965
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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HT Experiment

GSE202470 | RNA-seq analysis of SIRT6 and STAT6 regulated genes in intestinal epithelial cells (IECs)


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

•

HT Experiment

GSE221077 | SIRT6 is a key regulator of mitochondrial function in the brain


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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Publication

28228253 | J:254343

First Author:	Ioris RM
Year:	2017
Journal:	Cell Rep
Title:	SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.
Volume:	18
Issue:	8
Pages:	1858-1868

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Publication

34212132 | J:339999

First Author:	Samant SA
Year:	2021
Journal:	JCSM Rapid Commun
Title:	Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
Volume:	4
Issue:	1
Pages:	40-56

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Publication

38081972 | J:343425

First Author:	Andreani C
Year:	2023
Journal:	Sci Rep
Title:	SIRT6 promotes metastasis and relapse in HER2-positive breast cancer.
Volume:	13
Issue:	1
Pages:	22000

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HT Experiment

E-GEOD-56563 | SIRT6 regulates glucose metabolism and glutamatergic synapse in the mouse retina

Series Id:	GSE56563
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

28887543 | J:256348

First Author:	Long D
Year:	2017
Journal:	Sci Rep
Title:	The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Volume:	7
Issue:	1
Pages:	11005

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Publication

37611438 | J:341114

First Author:	Abbotto E
Year:	2023
Journal:	Biomed Pharmacother
Title:	SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma.
Volume:	166

Pages:	115326

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Publication

23514751 | J:199021

First Author:	Khongkow M
Year:	2013
Journal:	Carcinogenesis
Title:	SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
Volume:	34
Issue:	7
Pages:	1476-86

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Publication

33903120 | J:307932

First Author:	Du L
Year:	2021
Journal:	Cancer Res
Title:	USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization.
Volume:	81
Issue:	14
Pages:	3822-3834

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Publication

25777360 | J:233440

First Author:	Stöhr R
Year:	2015
Journal:	Sci Rep
Title:	ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice.
Volume:	5

Pages:	9023

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Publication

36252808 | J:334217

First Author:	Zhao X
Year:	2022
Journal:	Free Radic Biol Med
Title:	NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
Volume:	193
Issue:	Pt 1
Pages:	342-353

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Publication

28386046 | J:252339

First Author:	Sociali G
Year:	2017
Journal:	FASEB J
Title:	Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Volume:	31
Issue:	7
Pages:	3138-3149

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Publication

28477980 | J:261004

First Author:	He Y
Year:	2017
Journal:	Exp Cell Res
Title:	SIRT6 inhibits TNF-α-induced inflammation of vascular adventitial fibroblasts through ROS and Akt signaling pathway.
Volume:	357
Issue:	1
Pages:	88-97

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Publication

36172184 | J:330101

First Author:	Li X
Year:	2022
Journal:	Front Pharmacol
Title:	SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease.
Volume:	13

Pages:	1007168

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Interaction Experiment

Hwang BJ (2015)

Description:

SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp.

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Publication

29599436 | -

First Author:	Gao Y
Year:	2018
Journal:	Sci Rep
Title:	SIRT6 facilitates directional telomere movement upon oxidative damage.
Volume:	8
Issue:	1
Pages:	5407

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Allele

Sirt6<em1Smoc> | MGI:7292338

Name:	sirtuin 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Conditional ready, No functional change

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Publication

19597350 | -

First Author:	Yang B
Year:	2009
Journal:	Cell Cycle
Title:	The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.
Volume:	8
Issue:	16
Pages:	2662-3

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Publication

26063178 | -

First Author:	Hwang BJ
Year:	2015
Journal:	BMC Mol Biol
Title:	SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clamp.
Volume:	16

Pages:	12

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Strain

MGI:6476283 | C57BL/6-Sirt6<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

HT Experiment

E-GEOD-67780 | Expression array from SIRT6WT and SIRT6KO muscle

Series Id:	GSE67780
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

32538779 | -

First Author:	Meng F
Year:	2020
Journal:	Elife
Title:	Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
Volume:	9

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Allele

Tg(RP23-352G18)1Coppa | MGI:5696226

Name:	transgene insertion 1, Roberto Coppari
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

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Allele

Gt(ROSA)26Sor<tm1(Sirt6)Mpgu> | MGI:7525638

Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mahesh P Gupta
Allele Type:	Targeted
Attribute String:	Conditional ready, Epitope tag, Inserted expressed sequence

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Publication

30787391 | J:303327

First Author:	Moon YJ
Year:	2019
Journal:	Cell Death Differ
Title:	Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α.
Volume:	26
Issue:	11
Pages:	2358-2370

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Strain

MGI:5696229 | C57BL/6-Tg(RP23-352G18)1Coppa/J

Attribute String:

transgenic, mutant strain, coisogenic

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Strain

MGI:5750461 | C57BL/6-Tg(RP23-352G18)1Coppa

Attribute String:

coisogenic, mutant strain, transgenic

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Genotype

Symbol:	Tg(RP23-352G18)1Coppa/?
Background:	C57BL/6-Tg(RP23-352G18)1Coppa
Zygosity:	ot
Has Mutant Allele:	true

•

Publication

19151729 | J:146526

First Author:	Van Gool F
Year:	2009
Journal:	Nat Med
Title:	Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Volume:	15
Issue:	2
Pages:	206-10

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Publication

31537782 | J:279348

First Author:	Chen J
Year:	2019
Journal:	Nat Commun
Title:	TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
Volume:	10
Issue:	1
Pages:	4273

•

Publication

31735643 | J:286261

First Author:	Zhu Y
Year:	2020
Journal:	Mol Cell
Title:	Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
Volume:	77
Issue:	1
Pages:	138-149.e5

•

Publication

24877878 | J:317514

First Author:	Giblin W
Year:	2014
Journal:	Trends Genet
Title:	Sirtuins: guardians of mammalian healthspan.
Volume:	30
Issue:	7
Pages:	271-86

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Publication

34125994 | J:315086

First Author:	Bang IH
Year:	2021
Journal:	Aging Cell
Title:	Sirtuin 6 promotes eosinophil differentiation by activating GATA-1 transcription factor.
Volume:	20
Issue:	7
Pages:	e13418

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Publication

32014438 | J:292774

First Author:	Harlan BA
Year:	2020
Journal:	Exp Neurol
Title:	Evaluation of the NAD⁺ biosynthetic pathway in ALS patients and effect of modulating NAD⁺ levels in hSOD1-linked ALS mouse models.
Volume:	327

Pages:	113219

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Publication

25658474 | J:229048

First Author:	Sargent KM
Year:	2015
Journal:	PLoS One
Title:	Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice.
Volume:	10
Issue:	2
Pages:	e0116332

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Publication

25404738 | J:337364

First Author:	Liu TF
Year:	2015
Journal:	J Biol Chem
Title:	Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Volume:	290
Issue:	1
Pages:	396-408

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Publication

24015318 | J:204515

First Author:	Xiong X
Year:	2013
Journal:	PLoS One
Title:	Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.
Volume:	8
Issue:	8
Pages:	e74340

•

Publication

31559637 | J:281650

First Author:	Lin W
Year:	2019
Journal:	Immunology
Title:	Sirtuin4 suppresses the anti-neuroinflammatory activity of infiltrating regulatory T cells in the traumatically injured spinal cord.
Volume:	158
Issue:	4
Pages:	362-374

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Publication

35314684 | J:323001

First Author:	Sebastian C
Year:	2022
Journal:	Nat Commun
Title:	A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Volume:	13
Issue:	1
Pages:	1503

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Publication

24211200 | J:211504

First Author:	Lin J
Year:	2013
Journal:	Biochem Biophys Res Commun
Title:	Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Volume:	441
Issue:	4
Pages:	897-903

•

Publication

23860128 | J:200088

First Author:	Lefort K
Year:	2013
Journal:	EMBO J
Title:	A miR-34a-SIRT6 axis in the squamous cell differentiation network.
Volume:	32
Issue:	16
Pages:	2248-63

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Publication

24687991 | J:216530

First Author:	Buler M
Year:	2014
Journal:	FASEB J
Title:	SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.
Volume:	28
Issue:	7
Pages:	3225-37

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Publication

27041572 | J:235982

First Author:	Na TY
Year:	2016
Journal:	Oncogene
Title:	Interaction of hepatitis B virus X protein with PARP1 results in inhibition of DNA repair in hepatocellular carcinoma.
Volume:	35
Issue:	41
Pages:	5435-5445

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Publication

34702956 | J:314696

First Author:	Tsai YC
Year:	2021
Journal:	Exp Mol Med
Title:	Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency.
Volume:	53
Issue:	10
Pages:	1623-1635

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Publication

31904088 | J:285394

First Author:	Liu W
Year:	2020
Journal:	Biosci Rep
Title:	Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice.
Volume:	40
Issue:	2

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Publication

23997094 | J:204531

First Author:	Roos CM
Year:	2013
Journal:	Am J Physiol Heart Circ Physiol
Title:	Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice.
Volume:	305
Issue:	10
Pages:	H1428-39

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Publication

36215093 | J:332536

First Author:	Nabi D
Year:	2023
Journal:	Reproduction
Title:	Multidrug resistance transporter-1 dysfunction perturbs meiosis and Ca2+ homeostasis in oocytes.
Volume:	165
Issue:	1
Pages:	79-91

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Publication

31090947 | J:295861

First Author:	Wang S
Year:	2019
Journal:	J Cell Biochem
Title:	Promotion of PTEN on apoptosis through PI3K/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease.
Volume:	120
Issue:	9
Pages:	14636-14644

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