Growth Arrest Specific protein 7 (GAS7) is mainly expressed in the brain and is required for neurite outgrowth []. It may also play a role in the protection and migration of embryonic stem cells []. Treatment-related acute myeloid leukemia (AML) has been reported resulting from mixed-lineage leukemia (MLL)-GAS7 translocations as a complication of primary cancer treatment []. GAS7 contains an N-terminal SH3 domain, followed by a WW domain, and a central F-BAR domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules []. This entry represents the F-BAR domain of GAS7.
