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Search results 201 to 237 out of 237 for Trim21

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0.019s

Type

Details

Score

Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

•

Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

•

Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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UniProt Feature

Begin:	1
Description:	E3 ubiquitin-protein ligase TRIM21
Type:	chain
End:	470

•

Publication

32312982 | J:289154

First Author:	Cheng J
Year:	2020
Journal:	Nat Commun
Title:	TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism.
Volume:	11
Issue:	1
Pages:	1880

•

Publication

26506431 | J:248342

First Author:	Watkinson RE
Year:	2015
Journal:	PLoS Pathog
Title:	TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
Volume:	11
Issue:	10
Pages:	e1005253

•

Publication

36749630 | J:334071

First Author:	Liu J
Year:	2023
Journal:	J Clin Invest
Title:	The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
Volume:	133
Issue:	6

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Interaction Experiment

Keeble AH (2008)

Description:

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.

•

Interaction Experiment

Zhang Z (2012)

Description:

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.

•

Publication

18420815 | -

First Author:	Keeble AH
Year:	2008
Journal:	Proc Natl Acad Sci U S A
Title:	TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
Volume:	105
Issue:	16
Pages:	6045-50

•

Publication

19265157 | -

First Author:	Yang K
Year:	2009
Journal:	J Immunol
Title:	TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response.
Volume:	182
Issue:	6
Pages:	3782-92

•

Allele

Trim21<em1Smoc> | MGI:7292968

Name:	tripartite motif-containing 21; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Strain

MGI:6355306 | C57BL/6J-Trim21<em1Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

•

Publication

38591006 | J:347630

First Author:	Deng R
Year:	2024
Journal:	iScience
Title:	ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-catenin/PD-L1 axis.
Volume:	27
Issue:	4
Pages:	109533

•

Publication

32796032 | J:298721

First Author:	Xie S
Year:	2020
Journal:	J Biol Chem
Title:	HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21.
Volume:	295
Issue:	42
Pages:	14343-14351

•

Publication

30367038 | J:267718

First Author:	Wei Z
Year:	2018
Journal:	Nat Commun
Title:	Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis.
Volume:	9
Issue:	1
Pages:	4468

•

Publication

23091005 | J:191235

First Author:	Hauler F
Year:	2012
Journal:	Proc Natl Acad Sci U S A
Title:	AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Volume:	109
Issue:	48
Pages:	19733-8

•

Publication

26442586 | J:251755

First Author:	Shibata N
Year:	2015
Journal:	J Biol Chem
Title:	Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Volume:	290
Issue:	47
Pages:	28428-37

•

Publication

36662617 | J:342798

First Author:	Kong X
Year:	2023
Journal:	Cell Rep
Title:	Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner.
Volume:	42
Issue:	1
Pages:	112002

•

Publication

17400754 | -

First Author:	James LC
Year:	2007
Journal:	Proc Natl Acad Sci U S A
Title:	Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.
Volume:	104
Issue:	15
Pages:	6200-5

•

Publication

22402340 | -

First Author:	Oke V
Year:	2012
Journal:	J Autoimmun
Title:	The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review.
Volume:	39
Issue:	1-2
Pages:	77-82

•

Publication

16670339 | -

First Author:	Espinosa A
Year:	2006
Journal:	J Immunol
Title:	The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
Volume:	176
Issue:	10
Pages:	6277-85

•

Protein Domain

IPR035831 | PRY/SPRY_TRIM21

Type:

Domain

Description:

This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM21, which is also known as Sjogren Syndrome Antigen A (SSA), SSA1, 52kDa Ribonucleoprotein Autoantigen (Ro52, Ro/SSA, SS-A/Ro) or RING finger protein 81 (RNF81). TRIM proteins are defined by the presence of the tripartite motif RING/B-box/coiled-coil region and also known as RBCC proteins []. As an E3 ligase, TRIM21 mediates target specificity in ubiquitination; it regulates type 1 interferon and proinflammatory cytokines via ubiquitination of interferon regulatory factors (IRFs) [, ]. It is up-regulated at the site of autoimmune inflammation, such as cutaneous lupus lesions, indicating a central role in the tissue destructive inflammatory process []. It interacts with auto-antigens in patients with Sjogren syndrome and systemic lupus erythematosus, a chronic systemic autoimmune disease characterized by the presence of autoantibodies against the protein component of the human intracellular ribonucleoprotein-RNA complexes and more specifically TRIM21, Ro60/TROVE2 and La/SSB proteins []. It binds the Fc part of IgG molecules via its PRY-SPRY domain with unexpectedly high affinity [, ].

•

Publication

23975864 | J:205843

First Author:	Sjöstrand M
Year:	2013
Journal:	J Immunol
Title:	Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
Volume:	191
Issue:	7
Pages:	3753-63

•

Publication

31638890 | J:281684

First Author:	Israel S
Year:	2019
Journal:	BMC Genomics
Title:	A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days.
Volume:	20
Issue:	1
Pages:	755

•

Publication

16237670 | J:102328

First Author:	Meroni G
Year:	2005
Journal:	Bioessays
Title:	TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases.
Volume:	27
Issue:	11
Pages:	1147-57

•

Protein

Q921V6

Organism:	Mus musculus/domesticus
Length:	470
Fragment?:	false

•

Protein

Q3U7K7

Organism:	Mus musculus/domesticus
Length:	462
Fragment?:	false

•

Protein

Q3UCL2

Organism:	Mus musculus/domesticus
Length:	462
Fragment?:	false

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

•

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