Type |
Details |
Score |
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Baron BW |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. |
Volume: |
1852 |
Issue: |
5 |
Pages: |
742-8 |
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Allele |
Name: |
integral membrane protein 2B; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Publication |
First Author: |
Tai TS |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. |
Volume: |
9 |
Issue: |
5 |
Pages: |
e96535 |
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DO Term |
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Publication |
First Author: |
Rengaraj D |
Year: |
2007 |
Journal: |
Endocrine |
Title: |
Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues. |
Volume: |
31 |
Issue: |
2 |
Pages: |
193-201 |
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Publication |
First Author: |
Hedlund J |
Year: |
2009 |
Journal: |
BMC Res Notes |
Title: |
BRICHOS - a superfamily of multidomain proteins with diverse functions. |
Volume: |
2 |
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Pages: |
180 |
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Publication |
First Author: |
Knight SD |
Year: |
2013 |
Journal: |
Biochemistry |
Title: |
The BRICHOS domain, amyloid fibril formation, and their relationship. |
Volume: |
52 |
Issue: |
43 |
Pages: |
7523-31 |
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Publication |
First Author: |
Fotinopoulou A |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. |
Volume: |
280 |
Issue: |
35 |
Pages: |
30768-72 |
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Publication |
First Author: |
Peng S |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation. |
Volume: |
393 |
Issue: |
3 |
Pages: |
356-61 |
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Publication |
First Author: |
Matsuda S |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. |
Volume: |
284 |
Issue: |
23 |
Pages: |
15815-25 |
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Protein Domain |
Type: |
Family |
Description: |
The family of type 2 integral membrane protein (ITM2) consists of three members, ITM2A, ITM2B and ITM2C []. Members of this family contain a BRICHOS domain, which possesses chaperone activity [,].ITM2A is a target gene of GATA-3, a T cell-specific transcription factor [].ITM2B is proteolytically cleaved at three locations; cleavage by furin in the C-terminal region generates a 23-residue peptide (ABri23), processing by ADAM10 results in release of the BRICHOS domain from the membrane-bound N-terminal part and intramembrane cleavage by SPPL2a/2b liberates the intracellular domain []. ITM2B (BRI2) is a target of BCL6 transcriptional repression and a short form of the ITM2B protein, similarly to other targets of BCL6, induces apoptosis in hematopoietic cell lines []. ITM2B interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production [, ]. ITM2C (BRI3) also inhibits amyloid precursor protein processing, but through a different mechanism to ITM2B []. |
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DO Term |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
263
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
|
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
210
|
Fragment?: |
false |
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•
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
|
Fragment?: |
false |
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
144
|
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
266
|
Fragment?: |
false |
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Publication |
First Author: |
Martin L |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. |
Volume: |
283 |
Issue: |
3 |
Pages: |
1644-52 |
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Allele |
Name: |
transgene insertion 8.4, Luciano D'Adamio |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Strain |
Attribute String: |
congenic, mutant strain, targeted mutation, transgenic |
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Genotype |
Symbol: |
Tg(Camk2a-ITM2B)8.4Ldad/? Tg(PRNP-APPSweInd)8Dwst/? |
Background: |
involves: C3H/HeJ * C57BL/6J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Itm2b/Itm2b<+> Tg(Camk2a-ITM2B)8.4Ldad/? |
Background: |
B6.Cg-Itm2b Tg(Camk2a-ITM2B)8.4Ldad |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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