|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 125 out of 125 for Cd2bp2

<< First    < Previous  |  Next >    Last >>
0.017s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:6474941 | C57BL/6-Cd2bp2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Protein
Q99MR1
Organism: Mus musculus/domesticus
Length: 1044  
Fragment?: false
•
•
•
•
•
Protein
Q6Y7W8
Organism: Mus musculus/domesticus
Length: 1291  
Fragment?: false
•
•
•
•
•
Protein
Q3TUA5
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: true
•
•
•
•
•
Protein
G3UWR2
Organism: Mus musculus/domesticus
Length: 1122  
Fragment?: false
•
•
•
•
•
Protein
G3UYG6
Organism: Mus musculus/domesticus
Length: 1285  
Fragment?: false
•
•
•
•
•
Protein
G3UZX7
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
•
•
•
•
•
Protein
E9Q2M5
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: true
•
•
•
•
•
Protein
Q8C585
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: true
•
•
•
•
•
Protein
G3UYR9
Organism: Mus musculus/domesticus
Length: 877  
Fragment?: true
•
•
•
•
•
Publication
9843987 | -
First Author: Nishizawa K
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Identification of a proline-binding motif regulating CD2-triggered T lymphocyte activation.
Volume: 95
Issue: 25
Pages: 14897-902
•
•
•
•
•
Publication
10404223 | -
First Author: Freund C
Year: 1999
Journal: Nat Struct Biol
Title: The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.
Volume: 6
Issue: 7
Pages: 656-60
•
•
•
•
•
Publication
12426371 | -
First Author: Freund C
Year: 2002
Journal: EMBO J
Title: Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.
Volume: 21
Issue: 22
Pages: 5985-95
•
•
•
•
•
Protein Domain
IPR003169 | GYF
Type: Domain
Description: The glycine-tyrosine-phenylalanine (GYF) domain is an around 60-amino acid domain which contains a conserved GP[YF]xxxx[MV]xxWxxx[GN]YF motif. It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2. Binding experiments and mutational analyses have demonstrated the critical importance of the GYF tripeptide in ligand binding. A GYF domain is also found in several other eukaryotic proteins of unknown function []. It has been proposed that the GYF domain found in these proteins could also be involved in proline-rich sequence recognition [].Resolution of the structure of the CD2BP2 GYF domain by NMR spectroscopy revealed a compact domain with a β-β-α-β-beta topology, where the single α-helix is tilted away from the twisted, anti-parallel β-sheet. The conserved residues of the GYF domain create a contiguous patch of predominantly hydrophobic nature which forms an integral part of the ligand-binding site []. There is limited homology within the C-terminal 20-30 amino acids of various GYF domains, supporting the idea that this part of the domain is structurally but not functionally important [].
•
•
•
•
•
Protein
Q9CWK3
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
•
•
•
•
•
Protein
Q3U4A3
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
•
•
•
•
•
Protein
Q69ZP6
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: true
•
•
•
•
•
Publication
21037105 | -
First Author: Berr A
Year: 2010
Journal: Plant Cell
Title: Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and is crucial for both sporophyte and gametophyte development.
Volume: 22
Issue: 10
Pages: 3232-48
•
•
•
•
•
Publication
12805620 | -
First Author: Springer NM
Year: 2003
Journal: Plant Physiol
Title: Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots.
Volume: 132
Issue: 2
Pages: 907-25
•
•
•
•
•
Protein Domain
IPR035445 | GYF-like_dom_sf
Type: Homologous_superfamily
Description: The glycine-tyrosine-phenylalanine (GYF) domain is an around 60-amino acid domain which contains a conserved GP[YF]xxxx[MV]xxWxxx[GN]YF motif. It was identified in the human intracellular protein termed CD2 binding protein 2 (CD2BP2), which binds to a site containing two tandem PPPGHR segments within the cytoplasmic region of CD2. Binding experiments and mutational analyses have demonstrated the critical importance of the GYF tripeptide in ligand binding. A GYF domain is also found in several other eukaryotic proteins of unknown function []. It has been proposed that the GYF domain found in these proteins could also be involved in proline-rich sequence recognition [].Resolution of the structure of the CD2BP2 GYF domain by NMR spectroscopy revealed a compact domain with a β-β-α-β-beta topology, where the single α-helix is tilted away from the twisted, anti-parallel β-sheet. The conserved residues of the GYF domain create a contiguous patch of predominantly hydrophobic nature which forms an integral part of the ligand-binding site []. There is limited homology within the C-terminal 20-30 amino acids of various GYF domains, supporting the idea that this part of the domain is structurally but not functionally important [].This entry also matches Arabidopsis histone methyltransferases ATXR3/SDG2 and ATXR7/SDG25, which contain two partial GYF domains towards the N terminus []. Histone methyltransferase ATXR7 is involved in regulation of flowering time []. It is specifically required for the trimethylation of 'Lys-4' of histone H3 (H3K4me3) at the FLC locus, it prevents the trimethylation on 'Lys-27' (H3K27me3) at the same locus. ATXR3 is also required for H3K4 trimethylation and is crucial for both sporophyte and gametophyte development in plants [, ].
•
•
•
•
•
Protein
A0A087WRC9
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
•
•
•
•
•
Publication
20937886 | -
First Author: Guo L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis.
Volume: 107
Issue: 43
Pages: 18557-62
•
•
•
•
•
Publication
19855050 | -
First Author: Tamada Y
Year: 2009
Journal: Plant Cell
Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
Volume: 21
Issue: 10
Pages: 3257-69
•
•
•
•
•
Protein
D4AFX7
Organism: Mus musculus/domesticus
Length: 2248  
Fragment?: false
•
•
•
•
•
Protein
G3X922
Organism: Mus musculus/domesticus
Length: 2243  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom