Stac proteins are putative adaptor proteins that contain a cysteine-rich C1 domain and one or two SH3 domains at the C terminus. There are three mammalian members: Stac1, Stac2, and Stac3. Stac1 and Stac3 contain two SH3 domains while Stac2 contains a single SH3 domain at the C terminus. They regulate voltage-gated calcium channel (CaV) trafficking and function [, ]. This entry represents Stac1. Stac1 and Stac2 have been found to be expressed differently in mature dorsal root ganglia (DRG) neurons. Stac1 is mainly expressed in peptidergic neurons while Stac2 is found in a subset of nonpeptidergic and all trkB+ neurons [].
Stac proteins are putative adaptor proteins that contain a cysteine-rich C1 domain and one or two SH3 domains at the C terminus. There are three mammalian members (Stac1, Stac2, and Stac3) of this family. Stac2 contains a single SH3 domain at the C terminus unlike Stac1 and Stac3, which contain two C-terminal SH3 domains. Stac1 and Stac2 have been found to be expressed differently in mature dorsal root ganglia (DRG) neurons. Stac1 is mainly expressed in peptidergic neurons while Stac2 is found in a subset of nonpeptidergic and all trkB+ neurons [].This entry represents the SH3 domain of Stac2.
Stac proteins are putative adaptor proteins that contain a cysteine-rich C1 domain and one or two SH3 domains at the C terminus. There are three mammalian members: Stac1, Stac2, and Stac3. Stac1 and Stac3 contain two SH3 domains while Stac2 contains a single SH3 domain at the C terminus. They regulate voltage-gated calcium channel (CaV) trafficking and function [, ].
Stac (SH3 and cysteine-rich domain-containing) proteins are putative adaptor proteins that contain a cysteine-rich C1 domain and one or two SH3 domains at the C terminus. There are three mammalian members (Stac1, Stac2, and Stac3) of this family. Stac1 and Stac3 contain two SH3 domains while Stac2 contains a single SH3 domain at the C terminus. Stac3 is specific to skeletal muscle and is a component of the excitation-contraction coupling machinery. A mutation in the Stac3 gene has been linked to a severe muscle disease, Native American myopathy (NAM) [, ].This entry represents the first SH3 domain of Stac3.
